Production method and application of nutgall effective part used for preventing and treating periodontal disease and inflammatory bowel disease

A technology of effective parts and production methods, which is applied in the field of pharmaceutical use for the prevention and treatment of periodontal disease and inflammatory bowel disease, and achieves the effect of improving accuracy and efficiency

Inactive Publication Date: 2018-01-26
韩博
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no effective part of gallon anti-inflammatory bowel disease based on the effec

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The first step: the galls produced by the larvae of the Gallaceae insect Gallaceae parasitizing on the twigs of the Fagaceae Quercus infectoria Oliv. are selected as the Gallaceae medicinal material;

[0018] Step 2: Grind the gallic medicinal material, pass through a 30-mesh sieve, use water as a solvent, and reflux extract the crushed gall for 3 times for 2 hours each time, and combine the extracts;

[0019] The third step: the combined extract obtained in the second step is subjected to column chromatography on a polyamide resin or a macroporous adsorption resin in an exchange device, firstly eluted with pure water and then with a 30% ethanol aqueous solution gradient, and analyzed by liquid mass spectrometry The fractions containing mass-to-charge ratios of 321±1 and 635±1 were measured and collected, and the effective fractions of gallic tannins were obtained after drying. The contents of gallic acid and total tannins were 83% based on dry product weight. The effec...

Embodiment 2

[0021] The first step: the galls produced by the larvae of the Gallaceae insect Gallaceae parasitizing on the twigs of the Fagaceae Quercus infectoria Oliv. are selected as the Gallaceae medicinal material;

[0022] The second step: crush the medicinal material of gall, pass through a 40-mesh sieve, use 50% ethanol water as a solvent, and reflux extract the crushed gall twice for 3 hours each time, and combine the extracts;

[0023] The third step: the combined extract obtained in the second step is subjected to column chromatography on a polyamide resin or a macroporous adsorption resin in an exchange device, firstly eluted with pure water and then with a gradient of 25% methanol aqueous solution, and analyzed by liquid chromatography-mass spectrometry The fractions containing mass-to-charge ratios of 321±1 and 635±1 were measured and collected, and the effective fractions of gallic tannins were obtained after drying. The contents of gallic acid and total tannins were 85% base...

Embodiment 3

[0025] The first step: the galls produced by the larvae of the Gallaceae insect Gallaceae parasitizing on the twigs of the Fagaceae Quercus infectoria Oliv. are selected as the Gallaceae medicinal material;

[0026] The second step: pulverize the gallic medicinal material, pass through a 30-mesh sieve, use ethyl acetate as a solvent, and reflux extract the pulverized gallic twice for 3 hours each time, and combine the extracts;

[0027] The third step: the combined extract obtained in the second step is subjected to column chromatography on a polyamide resin or a macroporous adsorption resin in an exchange device, and firstly eluted with pure water and then with a 25% ethanol aqueous solution gradient, and liquid chromatography-mass spectrometry The fractions containing mass-to-charge ratios of 321±1 and 635±1 were measured and collected, and the effective parts of gallic tannins were obtained after drying. The contents of gallic acid and total tannins were 81% based on dry pro...

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Abstract

The invention relates to a production method and application of a nutgall effective part used for preventing and treating periodontal disease and inflammatory bowel disease. The production method is characterized by carrying out the following steps: taking a nutgall medicinal material; smashing the nutgall medicinal material; refluxing and extracting the smashed nutgall for 1-5 times in the presence of solvents (ethanol water and ethyl acetate), wherein extraction is carried out for 1-5 hours every time; mixing extract; carrying out column chromatography on the obtained mixed extract with polyamide resin or macroporous adsorption resin on exchange equipment; carrying out liquid chromatography-mass spectrometry determination and collecting fraction with the mass-to-charge ratio of 321 +/- 1and 635 +/- 1, and drying to thus obtain the nutgall effective part. The obtained nutgall effective part can strengthen teeth and gingival and is used for alleviating sore and weak teeth, chewing disability, looseness and displacement, gingival bleeding, mouth and tongue sores as well as swelling and pain in throat which are caused by the periodontal disease; and the nutgall effective part also can alleviate diarrhea and abdominal pain, mucus and bloody purulent stool as well as intestinal mucosal injury which are caused by the inflammatory bowel disease.

Description

technical field [0001] The invention relates to a production method and application of the effective parts of the gall gall for preventing and treating periodontal disease and inflammatory bowel disease, and specifically to separating active components from the medicinal material of gall gall for use as a medicine for preventing and treating periodontal disease and inflammatory bowel disease. Background technique [0002] Periodontal disease is a disease that occurs in the tooth supporting tissue (periodontal tissue), including gingival disease involving only gingival tissue and periodontitis involving deep periodontal tissue (periodontal ligament, alveolar bone, cementum) kind. Periodontal disease is a common oral disease, one of the main causes of adult tooth loss, and a major oral disease that endangers human teeth and general health. Xipayi Gingival Liquid (Guoyao Zhunzi Z65020012, recorded in the "Ministry of Health Drug Quality Standards of the People's Republic of Ch...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P1/02A61P7/04A61P11/04A61P29/00A61P1/00A61P1/12
Inventor 韩博张星陈文郭刚周良学谢智勇姚美村王新春曾涛江敏唐婷刘桂花
Owner 韩博
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