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Capsule preparations, preparation and quality control method thereof

A technology of capsules and preparations, which is applied to the preparation method and quality control of the traditional Chinese medicine capsule preparations. The traditional Chinese medicine capsule preparations for gingival swelling and pain can be used to treat stomach fire inflammation, and can solve the problems of melting with boiling water, easy moisture absorption and caking, and limited use range. issues of mass production

Inactive Publication Date: 2008-07-02
杨文龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine generally uses antibiotics, vitamins, and adrenal cortex hormones for treatment, but a large amount of antibiotics and adrenal cortex hormones will destroy the micro-ecological balance in the body, easily cause iatrogenic diseases and other serious side effects, and are not easy to take for a long time
[0003] The traditional Chinese medicine used for treating stomatitis in the market is Kouyan Granules, but it has the disadvantages of easy moisture absorption and caking, and unstable properties; the dosage of excipients in Kouyan Granules is large, the degree of preparation is low, and it needs to be dissolved in boiling water when taking it, which is inconvenient to take.
There are Kouyan granules (infusions) and tablets on the market, and the preparation method of sugar-free granules (infusions) and tablets has been declared for a national invention patent, and has been disclosed. The application numbers are respectively: 93111896.4 and 200610055014.9, but due to The above-mentioned dosage forms have the limitations of poor taste, inconvenient taking, and low bioavailability, which greatly limit their scope of use and large-scale production.

Method used

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  • Capsule preparations, preparation and quality control method thereof
  • Capsule preparations, preparation and quality control method thereof
  • Capsule preparations, preparation and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Prescription: 800g gypsum, 350g Anemarrhena, 380g rehmannia, 500g Scrophulariae, 300g Chuanketong, 280g light bamboo leaves, 220g Artemisia annua, 40g licorice, 550g isatidis root, 340g reed bamboo root, 180g catechu;

[0066] Preparation:

[0067] Grind the catechu, add appropriate amount of water to heat to dissolve, filter, and when the filtrate is concentrated to 65°C, measure Qinggao A with a relative density of 1.10, and set aside; mix gypsum, Anemarrhena, Rehmannia glutinosa, Scrophulariaceae, Chuanketong, Danzhuye, Artemisia annua, licorice, isatis root, and reed bamboo root are decocted twice, the first time is 2 hours, the second time is 1 hour, the decoctions are combined, filtered, and the filtrate is concentrated to 65°C to measure the clear paste B with a relative density of 1.25 The amount of water added is 10 or 8 times the total weight of gypsum, Anemarrhena, Rehmannia glutinosa, Scrophulariae scrophulariae, Akebia sichuan, Bamboo leaves, Artemisia annu...

Embodiment 2

[0070] Prescription: gypsum 950g, Anemarrhena 200g, Rehmannia glutinosa 500g, Scrophulariae 380g, Akebia sichuan 220g, Bamboo leaf 400g, Artemisia annua 300g, Licorice 110g, Radix isatidis 350g, Luzhu root 320g, Catechu 150g;

[0071] Preparation:

[0072] Grind catechu, add appropriate amount of water to heat to dissolve, filter, and when the filtrate is concentrated to 65°C, measure the clear paste A with a relative density of 1.25, and set aside; mix gypsum, Anemarrhena, Rehmannia glutinosa, Scrophulariaceae, Chuanketong, Danzhuye, Artemisia annua, licorice, isatidis, and reed bamboo root are decocted with water for 3 times, the first time is 1 hour, the second time is 2 hours, and the third time is 3 hours, the decoctions are combined, filtered, and the relative density is measured when the filtrate is concentrated to 65°C Clear paste B of 1.10; the amount of water added is 8, 10, and 6 times the total weight of gypsum, Anemarrhena, Rehmannia glutinosa, Scrophulariaceae, C...

Embodiment 3

[0075] Prescription: gypsum 1000g, Anemarrhena 290g, Rehmannia glutinosa 350g, Scrophulariae 480g, Akebia sichuan 200g, Bamboo leaf 220g, Artemisia annua 350g, Licorice 50g, Radix isatidis 415g, Luzhu root 300g, Catechu 270g;

[0076] Preparation:

[0077] Grind catechu, add appropriate amount of water to heat to dissolve, filter, and when the filtrate is concentrated to 65°C, measure Qinggao A with a relative density of 1.20, and set aside; mix gypsum, Anemarrhena, Rehmannia glutinosa, Scrophulariaceae, Chuanketong, Danzhuye, Artemisia annua, licorice, isatis root, and reed bamboo root are decocted twice, the first time is 2 hours, the second time is 1 hour, the decoctions are combined, filtered, and the filtrate is concentrated to 65°C to measure the clear paste B with a relative density of 1.20 The amount of water added is 8 or 6 times the total weight of gypsum, Anemarrhena, Rehmannia glutinosa, Scrophulariae scrophulariae, Akebia sichuan, Bamboo leaves, Artemisia annua, l...

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Abstract

The invention discloses a capsule preparation, the preparation method and the quality control method thereof, the catechu is smashed, dissolved by adding water and filtered, the filtrate is condensed into clear paste A for standby; the gypsum, common anemarrhena rhizome, rehmannia root, figwort root, anemone clematis stem, common lophatherum herb, sweet wormwood herb, liquoric root, Indigowoad root and arundo donax root are boiled by adding water and filtered, the filtrate is condensed into clear paste B; the clear paste A and the clear paste B are mixed evenly, condensed, dried and smashed to get fine powder, the ethanol is used for granulation, and finally the encapsulation is carried out. The traditional Chinese medicine capsule preparation which is prepared by the invention has the advantages of simple preparation process, low cost, convenient carry, high bioavailability, high degree of refinement of the product and convenient administration, and the invention can be used for the treatment of ascending of stomach fire, mouth and tongue sore, gum swelling and pain and other symptoms.

Description

technical field [0001] The invention relates to a traditional Chinese medicine capsule preparation for treating oral diseases, in particular to a traditional Chinese medicine capsule preparation for treating stomach fire inflammation, aphtha of the mouth and tongue, and swelling and pain of the gums. The invention also relates to a preparation method of the traditional Chinese medicine capsule preparation and quality control methods. Background technique [0002] The clinical manifestations of stomatitis are sores in stomatitis and swollen and painful gums, which are more common oral diseases. Western medicine generally uses antibiotics, vitamins, and adrenal corticosteroids for treatment, but a large amount of antibiotics and adrenal cortex hormones will destroy the micro-ecological balance in the body, easily cause iatrogenic diseases and other serious side effects, and are not easy to take for a long time. [0003] The traditional Chinese medicine used for treating stoma...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P1/02G01N30/90G01N30/02A61K33/06
Inventor 杨文龙
Owner 杨文龙
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