10results about How to "Maximize efficacy" patented technology

The invention discloses individual protection equipment, a consumable processing method, a consumable processing device and related equipment, relates to the technical field of individual protection, and aims to solve the problems that the existing individual protection equipment is difficult to realize full-process operation of consumable automatic output, consumable processing and consumable application and is relatively poor in use convenience. The individual protection equipment comprises an equipment body provided with a liquid outlet; the consumable bottle is connected with the equipment body and is used for accommodating at least one consumable; the consumable power equipment is connected with the consumable bottle and the consumable body and used for providing power and conveying the consumable in the consumable bottle to the liquid outlet through the consumable flow path; the processing device is connected with the equipment body, located on the consumable flow path and used for processing consumables on the consumable flow path, and the processing device comprises at least one of a temperature control device, an ultrasonic processing device, an optical processing device, a micro-current device and a radio frequency device. The personal care equipment provided by the embodiment of the invention can complete the full-operation process of automatic output, processing and application of consumables.

The invention discloses SiBCN ceramic slurry for direct-writing type 3D printing as well as a preparation method and a printing method of the SiBCN ceramic slurry, and belongs to the field of ceramic additive manufacturing. The invention aims to solve the problem of non-uniform selection and dispersion of SiBCN precursor filler in existing direct writing printing. And the slurry is prepared from cured polyborosilazane (PBSZ) powder, an inorganic rheological additive, a rheological synergist and a polyborosilazane (PBSZ) liquid. The preparation method comprises the following steps: 1, curing polyborosilazane (PBSZ); 2, ball-milling and crushing; (3) weighing; and 4, preparing slurry. The printing method comprises the steps of 1, printing a primary blank; and 2, curing and sintering. The SiBCN ceramic slurry for direct-writing type 3D printing and the preparation and printing thereof are provided by the invention.

The present invention relates to: an active camptothecin derivative (a) represented by Formula 1 designed so as to bind to a DDX5 protein and an E3 ligase; a prodrug (b) thereof, preferably an antibody-drug conjugate (ADC) thereof, designed so as to release the active camptothecin derivative (a) at a target site in vivo; the active camptothecin derivative (a) or the FL118 compound shown in the formula 2 is connected with a complex (c) containing a target DDX5 protein ligand through a joint, so that the 1-type topoisomerase inhibition capability in the active camptothecin derivative (a) or the FL118 compound shown in the formula 2 is inactivated. The active camptothecin derivative designed according to the present invention can bind to DDX5 protein in cells and induce cell death by degradation of the DDX5 protein.

A skin-permeable peptide, a derivative thereof, or a fragment thereof of the present disclosure effectively delivers skin bioactive molecules deep into the skin tissues through assembly or fusion methods, thereby providing outstanding skin permeability as well as excellent skin residual effect of bioactive materials to maximize bioactive efficacy. Accordingly, the skin-permeable peptide, derivative thereof, or fragment thereof may be widely used as an active ingredient of a pharmaceutical composition for external use and a functional cosmetic composition that target skin tissues including mucous membranes.

The invention relates to the technical field of food health care, and particularly discloses health-preserving health-care substitutional tea and a production method thereof, and the health-preserving health-care substitutional tea is prepared from the following raw materials in parts by weight: 10-15 parts of a qi-tonifying yin-benefiting medicine group, 5-10 parts of a blood-activating medicine group, 20-25 parts of a dampness-clearing medicine group, 30-40 parts of a qi-regulating medicine group, and 25-35 parts of a comprehensive conditioning medicine group. The comprehensive conditioning medicine group consists of gastrodia elata, semen brassicae junceae, cinnamon, endothelium corneum gigeriae galli, rose, rhizoma polygonati and malt; the five functional groups of tonifying qi and yin, activating blood, clearing damp, regulating qi and comprehensively conditioning are covered, various health requirements of people can be met, the production method is rigorous, each step from raw material purchasing to warehousing storage is strictly controlled, it is ensured that the raw materials are high in quality and free of impurities, and through precise functional classification, moderate smashing, reasonable mixing and strict sterilization and disinfection, the health-care food is prepared. The product quality, sanitation and safety are guaranteed, natural Chinese herbal medicines are adopted, no chemical additive is added, the side effect is low, the product stability is guaranteed through precise packaging and storage conditions, the product is suitable for a wide range of people, and a safe and effective health-preserving mode is provided for people.

The invention discloses a nursing system, a brush head, a bristle determination method and device and a readable storage medium, relates to the technical field of oral nursing, and aims to solve the problem that the effects of different consumables are difficult to maximize due to the fact that the matching degree of the bristles and the consumables is low. The method is applied to a control unit and comprises the steps that first target bristles corresponding to first target consumables are determined on the basis of a predefined corresponding relation between consumables and bristles, and / or first target bristles corresponding to a first target nursing mode are determined on the basis of a predefined corresponding relation between nursing modes and bristles; and controlling a target module to execute corresponding operation based on the first target nursing mode, wherein the target module comprises a brush head provided with the first target bristles. According to the embodiment of the invention, the used first target bristles can be matched with the first target consumable and / or the first target nursing mode.

The invention discloses a nursing method, equipment, system and device and a readable storage medium, relates to the technical field of personal care, and aims to solve the problems that existing nursing equipment can only output a single type of consumables, and selectable working modes are fixed and few in number. The method is applied to a control unit and comprises the following steps: determining a first consumable and a first nursing mode matched with the first consumable; and controlling a target module to execute corresponding operation on the first consumable based on the first nursing mode, wherein the target module comprises a sub-control power module. According to the embodiment of the invention, the consumables can be flexibly determined, the nursing mode matched with the consumables is used, and the selection flexibility and diversity of the consumables and the nursing mode are improved.

The present disclosure relates to a novel antibody-drug conjugate (ADC) targeting claudin 18 isoform 2 (CLDN18.2), an active metabolite of the ADC, a method of producing the ADC, use of the ADC for the treatment and / or prevention of diseases, and use of the ADC for producing a drug for the treatment and / or prevention of diseases, more specifically hyperproliferative and / or angiogenic diseases, for example, cancer, and more particularly, to an antibody-drug conjugate including a novel antibody or antigen-binding fragment thereof that binds to CLDN18.2, and a pharmaceutical composition including the same.

The invention discloses a high-stress-resistance black glutinous rice cultivation method, and belongs to the technical field of crop cultivation. The method specifically comprises the following steps: (1) soaking black glutinous rice seeds in concentrated sulfuric acid for 5-10 minutes, carrying out magnetization treatment, then taking out, disinfecting, washing and airing; (2) putting the treated black glutinous rice seeds into adjusting liquid seeds, and soaking for 20-30 hours; (3) soaking the seeds treated in the step (2) in a nutrient solution, and culturing until germination; and (4) after germination, transplanting the seedlings into a black glutinous rice seedling substrate for continuous cultivation, supplementing light with blue light with the illumination intensity of 800-1000Lx for 6-10 hours every day, and transplanting the seedlings 15-20 days later until the seedlings grow maturely. The black glutinous rice cultivation method is improved, and the survival rate, stress resistance and other characteristics of black glutinous rice seedlings can be effectively improved through cooperation of the specific cultivation process and reagents.

The present invention relates to the preparation of an anti-wrinkle and moisturizing freeze-dried powder composition, wherein the freeze-dried powder comprises an extract of a fermentation product of Alteromonas, soluble collagen, a porcine umbilical cord extract and a callus cell extract of Nymphoides; the essence comprises a composition and a solvent; the two components are prepared and stored separately, and the freeze-dried powder and the solvent are mixed before use. In order to solve the interaction between the increase of free radicals and the loss of collagen and water during skin aging, the present invention uses plant callus cell extracts, animal umbilical cord extracts and fungus fermentation product extracts as the main substances, and is matched with soluble collagen to achieve moisturizing the skin, deep hydration, brightening the skin tone, and anti-wrinkle and face-lifting.