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Medicinal composition for lowering blood pressure

A composition and technology for lowering blood pressure, which can be used in drug combinations, active ingredients of heterocyclic compounds, pharmaceutical formulations, etc., and can solve problems such as many adverse reactions

Inactive Publication Date: 2009-12-30
STAR LAKE BIOSCI CO INC ZHAOQING GUANGDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that there are many adverse reactions

Method used

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  • Medicinal composition for lowering blood pressure
  • Medicinal composition for lowering blood pressure
  • Medicinal composition for lowering blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 3

[0008] Embodiment 1 trichlorothiazide+enalapril tablet

[0009] prescription:

[0010]

[0011] Preparation:

[0012] Pass enalapril, microcrystalline cellulose, and compressible starch through 80-mesh sieves, stir well to make them uniform, and set aside; add trichlorothiazide to 50% ethanol solution to dissolve, add to the mixed powder, and make soft material, granulated with a 24-mesh sieve, dried, granulated with a 20-mesh sieve, added micropowder silica gel and CMS-Na, mixed evenly, and pressed into tablets with a suitable die to obtain the product.

[0013] If the above-mentioned tablet is coated, a coated tablet can be obtained, which can be a film-coated tablet, an enteric-coated tablet, and the like.

Embodiment 2

[0014] Embodiment 2: trichlorothiazide+enalapril capsules

[0015] prescription:

[0016]

[0017] Preparation:

[0018] Pass trichlorothiazide, enalapril and microcrystalline cellulose through an 80-mesh sieve, mix uniformly according to the method of equal volume addition, then add magnesium stearate, mix uniformly, pack separately, and obtain the product.

[0019] The used capsule shell can be a common capsule or an enteric-coated capsule.

Embodiment 3

[0020] Example 3: Trichlorothiazide and Benazepril Chewable Tablets

[0021] prescription:

[0022]

[0023]

[0024] Preparation:

[0025] Pass raw and auxiliary materials such as benazepril, xylitol, and mannitol through an 80-mesh sieve, and mix them uniformly by using an equal-volume increasing method, and then dissolve trichlorothiazide in 2% PVP-k30 ethanol solution to make a soft material, 16 mesh Sieve to granulate, dry, granulate with a 20-mesh sieve, add other flavoring agents, sweeteners, and glidants, mix evenly, and press into tablets to obtain the product.

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PUM

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Abstract

The invention relates to a medicinal composition for lowering blood pressure, which consists of trichlormethiazide and angiotensin converting enzyme inhibitor which serve as active ingredients and a pharmaceutical carrier, wherein the angiotensin converting enzyme inhibitor may be enalapril, cilazapril, benazepril, captopril, ramipril, perindopril and fosinopril. The unit dosage of trichlormethiazide is 0.5 to 8 milligrams, preferably 2 to 4 milligrams. The unit dosage of angiotensin converting enzyme inhibitor is 1.5 to 50 milligrams. The medicinal composition can be made into various oral preparations including conventional tablets, capsules, chewable tablets, dispersible tablets and effervescent tablets.

Description

technical field [0001] The invention relates to a pharmaceutical composition for lowering blood pressure, which is a pharmaceutical composition formed with trichlorothiazide and an angiotensin-converting enzyme inhibitor as active ingredients and a pharmaceutical carrier, and belongs to the technical field of pharmacy. Background technique [0002] As a first-line drug for the treatment of hypertension, diuretics have been widely used. It achieves natriuresis and diuresis by inhibiting the reabsorption of sodium and water by renal tubules, so that the excretion of sodium and water in the human body exceeds the intake, so that The blood volume and extracellular fluid volume decrease, and the cardiac output decreases, thereby achieving the antihypertensive effect. However, after 3 to 4 weeks of continuous medication, blood volume and cardiac output have gradually recovered, while blood pressure is still persistently reduced. Reactivity of vasoconstrictor substances such as no...

Claims

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Application Information

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IPC IPC(8): A61K31/549A61K45/06A61K31/40A61K31/55A61K31/404A61K31/675A61P9/12
Inventor 朱义福宁异真
Owner STAR LAKE BIOSCI CO INC ZHAOQING GUANGDONG
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