Hydrated perindopril salt, preparation method thereof and composition containing the same

A technology of perindopril and perindopril hydrate, which is applied in the field of perindopril hydrate salt, its preparation and use, and compositions containing it, and can solve the problems of time-consuming preparation methods and the like
CN1966519AInactive Publication Date: 2007-05-23CIPLA LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CIPLA LTD
Publication Date
2007-05-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a pharmaceutically acceptable salt of hydrated perindopril of formula (1a) wherein n is an integer of 1 to 5, or a reciprocal of integers 2 to 5. The present invention also relates to a process for preparing the salt, the use and the pharmaceutical composition containing the same.
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Description

[0001] This application is a divisional application of the Chinese patent application 200380108700.2 filed on November 18, 2003, and the invention name is "perindopril". technical field

[0002] The present invention relates to a process for the preparation of pharmaceutically acceptable salts of perindopril and their new polymorphs. Background technique

[0003] The international non-proprietary trade name of perindopril is (2S, 3aS, 7aS)-1-{2-[1-(ethoxycarbonyl)-(S)-butylamino]-(S)-propionyl}- Octahydroindole-2-carboxylic acid. Perindopril is known to have therapeutic applications as an angiotensin converting enzyme (ACE) inhibitor. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to angiotensin II and causes the degradation of bradykinin. Angiotensin II is a vasoconstrictor that also stimulates aldosterone secretion through the adrenal cortex. Therefore, inhibition of ACE has demonstrated therapeutic application in patients suffering from di...

Claims

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