Indapamide percutaneous controlled releast plaster and its preparation method

Abstract

A release-controllable percutaneous paster of indopamide for stable releasing within 24 hr is composed of substrate, layer, medicine bearing layer, and antisticking layer. Said medicine bearing layer contains indapamide, pressure sensitive adhesive, composite percutaneous absorption promoter, plasticizer, tackiness agent and antioxidant. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to an indapamide transdermal controlled-release patch and a preparation method. Background technique: [0002] Hypertension is the most common cardiovascular disease and a major public health problem worldwide. According to the forecast of the World Health Organization, by 2020, non-communicable diseases will account for 79% of the causes of death in my country, and cardiovascular diseases will take the first place. According to the circadian rhythm of cardiovascular disease and the damage to target organs caused by the total cardiovascular load in 24 hours, hypertensive patients should try to choose antihypertensive drugs with long half-life or slow and controlled release preparations to keep the blood drug concentration as stable as possible. [0003] Indapamide is a thiazide analogue and is an effective diuretic and antihypertensive drug. It has been used clinically since the ...

AI Technical Summary

Problems solved by technology

At present, indapamide preparations used clinically are mainly tablets, and there are no research reports on indapamide percutaneous absorption patches at home and abroad.

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