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Indapamide percutaneous controlled releast plaster and its preparation method

An indapamide and patch technology, which is applied in the field of indapamide transdermal controlled-release patches and preparation, can solve problems such as no research report on indapamide, and achieves lasting and stable curative effect, convenient use and softness good effect

Inactive Publication Date: 2006-08-30
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, indapamide preparations used clinically are mainly tablets, and there are no research reports on indapamide percutaneous absorption patches at home and abroad.

Method used

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  • Indapamide percutaneous controlled releast plaster and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Dissolve 1.0g of acrylic resin polymer in 3.0g of ethyl acetate, add 1.0g of absolute ethanol, 0.3g of propylene glycol, and 0.2g of indapamide, mix thoroughly, and evenly coat the anti-adhesive layer. Dry it for 20 minutes, then compound it with backing material including PVC or non-woven fabric, and punch it into a certain size and specification.

Embodiment 2

[0021] Except adding 0.3 g of azone, the same method as in Example 1 was used.

Embodiment 3

[0023] Except adding 0.6 g of azone, the same method as in Example 1 was used.

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PUM

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Abstract

A release-controllable percutaneous paster of indopamide for stable releasing within 24 hr is composed of substrate, layer, medicine bearing layer, and antisticking layer. Said medicine bearing layer contains indapamide, pressure sensitive adhesive, composite percutaneous absorption promoter, plasticizer, tackiness agent and antioxidant. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to an indapamide transdermal controlled-release patch and a preparation method. Background technique: [0002] Hypertension is the most common cardiovascular disease and a major public health problem worldwide. According to the forecast of the World Health Organization, by 2020, non-communicable diseases will account for 79% of the causes of death in my country, and cardiovascular diseases will take the first place. According to the circadian rhythm of cardiovascular disease and the damage to target organs caused by the total cardiovascular load in 24 hours, hypertensive patients should try to choose antihypertensive drugs with long half-life or slow and controlled release preparations to keep the blood drug concentration as stable as possible. [0003] Indapamide is a thiazide analogue and is an effective diuretic and antihypertensive drug. It has been used clinically since the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/404A61K9/70A61P9/12
Inventor 方亮任常顺何促贵
Owner SHENYANG PHARMA UNIVERSITY
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