The invention discloses a percutaneous drug delivery system based on a porous microneedle structure. The percutaneous drug delivery system comprises a porous microneedle, a polymer film, a pump, a liquid inlet pipe, a liquid outlet pipe, a liquid medicine feeding tank and a liquid medicine storage tank, wherein the polymer film wraps part of the microneedle, so that a tiny part of the needle point and a microneedle base are exposed out of the porous structure; the porous microneedle is connected with the liquid medicine feeding tank, the liquid medicine feeding tank is connected with one end of the liquid outlet pipe, the other end of the liquid outlet pipe is communicated with one end of the liquid inlet pipe in the pump, and the other end of the liquid inlet pipe is connected with the liquid medicine storage tank. The microneedle has a porous structure, therefore, liquid medicine can enter into an organism through multiple channels; and the pump is provided with a power supply and has stable flow. The whole system is simple in structure, easy to make, small in volume and high in efficiency.