Micro-needle array chip, percutaneous administration device, percutaneous administration patch and preparation method thereof

Abstract

The invention relates to a micro-needle array chip, a transdermal delivery device, a transdermal delivery patch and a preparation method thereof, wherein a micro-needle is obliquely fixed on a substrate at a set angle, the upper surface of the needle is an elliptic plane parallel to the substrate or obliquely provided with an acute angle, the needle is further treated to have more edge angles, a metal wire bar or tube penetrates a non-metallic material substrate such as polymer and the like along a certain angle, and then a nick of the metal wire bar or tube on the substrate is grinded and polished; and photosensitive resist patterns are formed nearby the nick at one end by adopting photoetching and etching technology, then the metal wire bar or tube is subjected to chemical or electrochemical corrosion to form a needle point and the photosensitive resist is removed, the surface of the manufactured solid micro-needle array chip can be covered with drugs, and the manufactured solid micro-needle array chip can deliver liquid medicine or extract body fluid. The method avoids the skin plugging a transfusion hole, is easy to adjust and control the maximum penetrating depth of the micro-needle, and is suitable for percutaneous transportation of biological macromolecular drugs and cosmetics and skincare and new percutaneous preparation of the prior drugs.

Description

technical field [0001] The invention relates to the technical fields of medical and beauty equipment, biomedicine and microfabrication, in particular to a microneedle array chip, a transdermal drug delivery device, a transdermal drug delivery patch and a preparation method. Background technique [0002] The therapeutic effect of a drug not only depends on the drug itself, but the drug delivery system also has a very important impact on the efficacy of the drug. For biomacromolecular drugs such as peptides, proteins, DNA, and vaccines represented by insulin, due to the degradation of enzymes in the gastrointestinal tract and the first-pass effect of the liver, the bioavailability of oral administration is very low and the curative effect cannot be achieved. . Subcutaneous injection can easily and quickly inject large doses of drugs into the human body and can make up for the shortcomings of oral administration, but its limitations are pain, injury at the injection point, inj...

AI Technical Summary

Problems solved by technology

[0015] In the above-mentioned documents, solid or hollow microneedle arrays of various shapes and substrates perpendicular to it are all formed on a piece of metal. The preparation methods include the following: 1) cutting the metal plate by chemical etching or laser cutting and Form various planar microneedle patterns on it, and then use methods such as stamping to lift these planar microneedles and finally be perpendicular to the metal plate. This method is only applicable to the manufacture of solid microneedle array chips; 2) for metal plates The surface is subjected to selective electrolysis or electrochemical corrosion to form raised microneedles. The solid microneedle structure prepared by this method needs to be improved in terms of aspect ratio and firmness; 3) methods such as electroplating and plastic casting Combined to make hollow metal microneedles, the needles of these microneedles are similar to the mouth of ordinary daily-use bottles, and if they can penetrate the skin, it is easy to cause blockage of the needle mouth channel

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