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Indapamide slow release tablet and its preparing method

A technology for indapamide and sustained-release tablets, applied in the field of indapamide sustained-release tablets and their preparation, can solve problems such as electrolyte and metabolic side effects

Inactive Publication Date: 2007-04-11
KANGYA OF NINGXIA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The indapamide currently on the market are all immediate-release preparations, such as capsules, tablets, granules, and dispersible tablets, etc., and this traditional indapamide immediate-release preparation quickly reaches a high dose after administration. concentration, can easily cause electrolyte and metabolic side effects

Method used

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  • Indapamide slow release tablet and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Indapamide 1.50g

[0023] Hydroxypropylmethylcellulose (HPMC K4M) 37.50g

[0024] Microcrystalline Cellulose 41.25g

[0025] Lactose 30.75g

[0026] Pregelatinized starch 37.50g

[0027] Magnesium Stearate 1.50g

[0028] Made into 1000 pieces

[0029] Preparation process Pass indapamide and all auxiliary materials through a 100-mesh sieve. First, indapamide and lactose are diluted and mixed uniformly at a ratio of 1:10, and then the mixture of each excipient, indapamide and lactose is passed through a 40-mesh sieve and mixed evenly according to the prescription amount, and then the powder is directly mixed. Compressed into 7mm tablets, that is, too.

Embodiment 2

[0031] Indapamide 1.5g

[0032] Hydroxypropyl Cellulose 38.0g

[0033] Microcrystalline Cellulose 63.4g

[0034] Lactose 11.2g

[0035] Copovidone (KOLLIDON  VA64) 7.5g

[0036] Pregelatinized starch 38.0g

[0037] Silica 10.0g

[0038] Made into 1000 pieces

[0039] Preparation process Pass indapamide and all auxiliary materials through a 60-mesh sieve. First, indapamide and lactose are diluted and mixed uniformly at a ratio of 1:10, and then the mixture of each excipient, indapamide and lactose is passed through a 40-mesh sieve and mixed evenly according to the prescription amount, and then the powder is directly mixed. Compressed into 7mm tablets, that is, too.

Embodiment 3

[0041] Indapamide 1.50g

[0042] HPMC K15M 37.50g

[0043] Microcrystalline Cellulose 31.25g

[0044] Lactose 40.75g

[0045] Pregelatinized starch 37.50g

[0046] Talc powder 1.50g

[0047] Made into 1000 pieces

[0048] Preparation process Pass indapamide and all auxiliary materials through a 100-mesh sieve. First, indapamide and lactose are diluted and mixed uniformly at a ratio of 1:10, and then the mixture of each excipient, indapamide and lactose is passed through a 60-mesh sieve and mixed evenly according to the prescription amount, and then the powder is directly mixed. Compressed into 7mm tablets, that is, too.

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PUM

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Abstract

The invention relates to a indapamide retard tablet and its preparation process, said retard tablet comprising indapamide, bone material, filler and lubricant, in each said tablet containing controllable 0.5-1.5mg( each tablet containing 0.15 g. or 150g / 1000 tablet ).

Description

technical field [0001] The invention relates to a new pharmaceutical dosage form of indapamide, in particular to an indapamide sustained-release tablet and a preparation method thereof. Background technique [0002] Hypertension is one of the most common clinical cardiovascular diseases and a risk factor for coronary heart disease. At present, there are many drugs used clinically to treat hypertension, such as calcium antagonists, diuretics, vasodilators, ACE inhibitors and β-adrenoceptor blockers. Indapamide is a new type of sulfonamide diuretic, which has antihypertensive, diuretic and calcium antagonistic effects, and is rapidly and completely absorbed orally, and has reliable curative effect. Therefore, it is mainly used clinically to treat various hypertension and edema, and is It is recommended by authoritative medical organizations as the first-line drug for the treatment of hypertension. [0003] The indapamide currently sold on the market are immediate-release pre...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/404A61P9/12
Inventor 张志华吴福鸿刘向红
Owner KANGYA OF NINGXIA PHARMA
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