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Antihypertensive medicine containing amlodipine besylate

A technology of amlodipine besylate and its composition, which is applied in the field of pharmaceutical compounds, can solve the problems of low treatment rate and control rate, and achieve the effects of significant antihypertensive effect, reduction of adverse reactions, and dose reduction

Active Publication Date: 2008-07-30
YIPINHONG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From the above statistics, it can be seen that the prevalence of hypertension in my country continues to increase, but the treatment rate and control rate are low, forming a huge contrast

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1. Materials and methods

[0017] 1.1 Case selection: Mild to moderate hypertensive patients aged 18 to 65 in outpatient and inpatient, sitting diastolic blood pressure 95 to 115 mmHg, systolic blood pressure <200 mmHg, not accompanied by serious target organ damage, male or female. The diagnosis of hypertension was in line with WHO criteria. The following conditions are excluded: severe liver or kidney dysfunction, severe alcohol and tobacco addiction, pregnant women, breastfeeding women, and those who have been ineffective or intolerable to the above-mentioned drug treatments in the past.

[0018] 1.2 Test method: All 120 patients stopped using other drugs that affect blood pressure for more than 5 half-lives before treatment, asked about medical history and various examinations in detail, except for secondary hypertension. They were randomly divided into 3 groups: ① Amlodipine besylate 2.5 mg / indapamide 10 mg; ② Indapamide 12.5 mg; ③ Amlodipine besylate 12.5 mg; onc...

Embodiment 2

[0033] 1. Materials and methods

[0034] 1.1 Case selection: Mild to moderate hypertensive patients aged 18 to 65 in outpatient and inpatient, sitting diastolic blood pressure 95 to 115 mmHg, systolic blood pressure <200 mmHg, not accompanied by serious target organ damage, male or female. The diagnosis of hypertension was in line with WHO criteria. The following conditions are excluded: severe liver or kidney dysfunction, severe alcohol and tobacco addiction, pregnant women, breastfeeding women, and those who have been ineffective or intolerable to the above-mentioned drug treatments in the past.

[0035] 1.2 Test method: All 120 patients stopped using other drugs that affect blood pressure for more than 5 half-lives before treatment, asked about medical history and various examinations in detail, except for secondary hypertension. They were randomly divided into 3 groups: ① Amlodipine besylate 2 mg / indapamide 12 mg; ② Indapamide 14 mg; ③ Amlodipine besylate 14 mg; once a da...

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PUM

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Abstract

The invention discloses an antihypertensive composition comprising amlodipine besylate and consists of the components with the following weight ratios: 1 portion of amlodipine besylate and 2 to 8 portions of indapamide which both have the antihypertensive effect, but more adverse reactions are produced when the amlodipine besylate or the indapamide is used respectively. The invention which combines the amlodipine besylate and the indapamide which can have a better synergistic effect in a certain proportion scope not only can reduce the adverse reactions and the doses but also has significant antihypertensive effects, wide application prospects and worth popularization.

Description

technical field [0001] The invention relates to the field of pharmaceutical compounds, in particular to a kind of antihypertensive medicine. Background technique [0002] Hypertension is the most common cardiovascular disease and a major public health problem worldwide. In 1991, my country conducted a sample survey of 940,000 people over the age of 15. Statistics show that the prevalence of hypertension in my country has reached 11.26%, which is 25% higher than that in the 10 years from 1979 to 1990. There are more than 130 million hypertensive patients in my country. . Moreover, this upward momentum continues. Statistics also show that the treatment rate of hypertension is 17.4% in urban areas and 5.4% in rural areas; the control rate (systolic blood pressure<140mmHg and diastolic blood pressure<90mmHg after treatment) is only 2.9%. From the above statistics, it can be seen that the prevalence of hypertension in my country is constantly increasing, but the treatment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61P9/12A61K31/404
Inventor 王勇
Owner YIPINHONG PHARMACEUTICAL CO LTD
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