Subcutaneous implant line for long effect pressure lowering

An implanted thread, long-acting technology, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, cardiovascular system diseases, etc., can solve the side effects of inability to achieve long-term stable blood pressure, slow, and after a week In order to reduce blood pressure, increase patients' surgical pain and other problems, achieve the effect of reducing surgical pain, slow degradation, and no side effects

Inactive Publication Date: 2018-09-07
朱军星
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there is also a precedent for treating hypertension with traditional Chinese medicine acupoint catgut embedding therapy, using sheep catgut and traditional Chinese medicine, but there is rejection in the body. Although the treatment effect is good, it cannot achieve long-term blood pressure stabilization and bring side effect
Another patent application No. 201410402016.5 is a biodegradable subcutaneous implant stick for long-term antihypertensive treatment. Although the carrier is also biodegradable, the drug release is slow after subcutaneous implantation, and it takes a week to reduce blood pressure. The degradation time is short, usually one year About half of it is completely degraded, and another surgical injection is required, which again increases the patient's surgical pain

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Subcutaneous implant line for long effect pressure lowering
  • Subcutaneous implant line for long effect pressure lowering
  • Subcutaneous implant line for long effect pressure lowering

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0167] API:

[0168] Lacidipine 6kg

[0169] Spironolactone 12kg

[0170] Indapamide 0.6kg;

[0171] Accessories:

[0172] Crospovidone 12kg

[0173] Polyethylene glycol 4kg

[0174] Carboxymethyl starch sodium 8kg.

[0175] Superfinely pulverize lacidipine, spironolactone and indapamide respectively to obtain fine powders for later use; put crospovidone and polyethylene glycol into the reaction kettle, heat at 130°C, and stir for 4 hours while heating , when the auxiliary materials in the reaction kettle are in a viscous state, add carboxymethyl starch sodium and continue to stir for 1 hour, and finally add lacidipine, indapamide and spironolactone superfine powder, and stir to obtain a mixture, mix The material is cooled and air-dried into a solid, pour the solid mixture into the extruder, extrude a cylindrical strip with a diameter of 2mm, and place the extruded cylindrical strip in a blast drying oven at 40°C for 7 hours, until the water evaporates completely Finall...

Embodiment 2

[0177] API:

[0178] Lacidipine 4kg

[0179] Spironolactone 15kg

[0180] Indapamide 0.4kg;

[0181] Accessories:

[0182] Crospovidone 16kg

[0183] Polyethylene glycol 3kg

[0184] Carboxymethyl starch sodium 11kg.

[0185] Superfinely pulverize lacidipine, spironolactone and indapamide respectively to obtain fine powders for later use; put crospovidone and polyethylene glycol into the reaction kettle, heat at 130°C, and stir for 4 hours while heating , when the auxiliary materials in the reaction kettle are in a viscous state, add carboxymethyl starch sodium and continue to stir for 1 hour, and finally add lacidipine, indapamide and spironolactone superfine powder, and stir to obtain a mixture, mix The material is cooled and air-dried into a solid, pour the solid mixture into the extruder, extrude a cylindrical strip with a diameter of 2mm, and place the extruded cylindrical strip in a blast drying oven at 40°C for 7 hours, until the water evaporates completely Final...

Embodiment 3

[0187] API:

[0188] Lacidipine 8kg

[0189] Spironolactone 9kg

[0190] Indapamide 0.8kg;

[0191] Accessories:

[0192] Crospovidone 8kg

[0193] Polyethylene glycol 7kg

[0194] Carboxymethyl starch sodium 5kg.

[0195]Superfinely pulverize lacidipine, spironolactone and indapamide respectively to obtain fine powders for later use; put crospovidone and polyethylene glycol into the reaction kettle, heat at 130°C, and stir for 4 hours while heating , when the auxiliary materials in the reaction kettle are in a viscous state, add carboxymethyl starch sodium and continue to stir for 1 hour, and finally add lacidipine, indapamide and spironolactone superfine powder, and stir to obtain a mixture, mix The material is cooled and air-dried into a solid, pour the solid mixture into the extruder, extrude a cylindrical strip with a diameter of 2mm, and place the extruded cylindrical strip in a blast drying oven at 40°C for 7 hours, until the water evaporates completely Finally, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to view more

Abstract

The invention discloses a subcutaneous implant line for long effect pressure lowering. The implant line is prepared from raw medicine of lacidipine, aldactone and indapamide and auxiliary materials ofcrosslinked povidone, polyethylene glycol and sodium carboxymethyl starch. The implant line is a cylindrical implant line prepared by mixing biodegradable materials as carriers and hypotensive medicine. The pressure lowering speed is high; the blood pressure can be stable after implantating for 3 days; the goal of stabilizing the blood pressure for a long time can be achieved. In addition, the degradation is slow; the complete degradation can be completed after about 3 years; the line implant line use time is long; the frequent operation implantation is not needed; the operation pain of patients is reduced.

Description

technical field [0001] The invention relates to a subcutaneous slow-release drug implanting thread, which is implanted under the skin and treats corresponding diseases according to the pharmacological properties of drugs mixed in the implanting thread, specifically a long-acting antihypertensive flexible Subcutaneous thread implantation for the treatment of hypertension. Background technique [0002] At present, the treatment of hypertension at home and abroad mostly relies on oral antihypertensive drugs to maintain normal and stable blood pressure. The drug has a short duration of action, and it needs to be taken orally once or twice a day. Taking a large amount of antihypertensive drugs orally has great side effects, causing systemic and gastrointestinal reactions and great damage to liver and kidney functions. Although there is also a precedent for treating hypertension with traditional Chinese medicine acupoint catgut embedding therapy, using sheep catgut and tradition...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K31/585A61K31/404A61K9/00A61K47/32A61K47/10A61K47/36A61P9/12
CPCA61K31/4422A61K9/0024A61K31/404A61K31/585A61K47/10A61K47/32A61K47/36A61P9/12A61K2300/00
Inventor 朱金光朱军星邱自琴
Owner 朱军星
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap