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Synergetic compound analgin injection and preparation method thereof

A technology for injection and analgin, which is applied to medical preparations containing active ingredients, pharmaceutical formulations, organic active ingredients, etc. The effect of improving the added value of products

Active Publication Date: 2013-05-08
金河牧星(重庆)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because Analgin has been used for a long time in the field of veterinary drugs, many bacteria have developed drug resistance, and the efficacy of traditional Analgin drugs has been significantly reduced.

Method used

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  • Synergetic compound analgin injection and preparation method thereof
  • Synergetic compound analgin injection and preparation method thereof
  • Synergetic compound analgin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 10% Veterinary Compound Analgin Injection

[0035] 1. Formula

[0036] Analgin: 10g, L-cysteine: 2g, dexamethasone sodium phosphate: 50mg, EDTA-Na2: 0.05g, add water for injection to 100ml; 10ml of 0.5mol / L sodium hydroxide solution and hydrochloric acid Keep a spare copy of each.

[0037] 2: Preparation method

[0038] Take 80% of the prescribed amount of water for injection and let it cool to 20°C, fill it with nitrogen for 10 minutes, then add EDTA-Na2, L-cysteine, and analgin in sequence, stir to dissolve them all, and adjust the pH with a small amount of pH regulator When the value reaches 5.5-6.5, it is prepared into liquid A and set aside;

[0039] Take a small amount of water for injection and dissolve dexamethasone sodium phosphate to prepare liquid B;

[0040] Add the above liquid B into liquid A and stir evenly, and continue to stir for 20 minutes. After the liquid is clear, use the adjusting reagent to adjust the pH value between 5.5-6.5 and constant vol...

Embodiment 2

[0044] 20% Veterinary Compound Analgin Injection

[0045] 1. Formula

[0046] Analgin: 20g, L-cysteine: 3g, dexamethasone sodium phosphate: 100mg, EDTA-Na2: 0.05g, water for injection, 10ml of 0.5mol / L sodium hydroxide solution and one part of hydrochloric acid spare.

[0047] 2: Preparation method: the same as the method described in Example 1.

Embodiment 3

[0049] 30% Veterinary Compound Analgin Injection

[0050] 1. Formula

[0051] Analgin: 30g, L-cysteine: 4g, dexamethasone sodium phosphate: 150mg, EDTA-Na2: 0.05g, water for injection, 10ml of 0.5mol / L sodium hydroxide solution and one part of hydrochloric acid spare.

[0052] 2: Preparation method: the same as the method described in Example 1.

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Abstract

The invention relates to a synergetic compound analgin injection and a preparation method thereof. The injection comprises the following components by weight in 100 milliliters: 10 to 30g of analgin, 2 to 4g of antioxidant, 50 to 150mg of dexamethasone sodium phosphate, 0.05g of EDTA (ethylene diamine tetraacetic acid)-Na2, injection water filled until the amount reaches 100ml, and proper pH regulating agent, wherein the usage of the pH regulating agent is sufficient to regulate the pH value of the system to be between 5.5 and 6.5. The preparation method comprises the following steps of adding the EDTA-Na2, the antioxidant and the analgin into the injection water, stirring until the EDTA-Na2, the antioxidant and the analgin are completely dissolved to prepare liquid A; dissolving the dexamethasone sodium phosphate with trace injection water to prepare liquid B; adding the liquid B into the liquid A, uniformly stirring, continuously stirring for 20 minutes, regulating the pH value to be between 5.5 and 6.5, and fixing the volume to 100ml; filtering medicinal liquid, filling the filtrate into a bottle with a filling and sealing machine; and sterilizing for 30 minutes at a temperature of 115 DEG C and at a pressure of 0.2MPa, and cooling and outputting to obtain a finished product. The dexamethasone sodium phosphate is added into the injection reasonably and compatibly, so that the antipyretic effect is reinforced, and the function of anti-inflammation and anti-allergy are given at the same time. The synergetic compound analgin injection is wide in drug effect and convenient to use.

Description

technical field [0001] The invention relates to a veterinary drug, in particular to synergistic compound Analgin injection and a preparation method thereof. Background technique [0002] Analgin (Metamizole Sodium Tablets), a common veterinary prescription drug. It is a combination compound of aminopyrine and sodium sulfite, which can be absorbed rapidly in animals and act quickly, and the drug effect can be maintained for 3-4 hours. The antipyretic effect is more significant, the analgesic effect is also stronger, and has certain anti-inflammatory and anti-rheumatic effects. No significant effect on gastrointestinal motility. For febrile illness, muscle pain, colic and rheumatism etc. However, because Analgin has been used for a long time in the field of veterinary drugs, many bacteria have developed drug resistance, and the curative effect of traditional Analgin drugs has been significantly reduced. Contents of the invention [0003] The invention provides a synergis...

Claims

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Application Information

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IPC IPC(8): A61K31/661A61K31/4152A61K9/08A61P29/00A61P37/08
Inventor 陈益德秦斌胡学全
Owner 金河牧星(重庆)生物科技有限公司
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