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Preparation method of superparamagnetism conductive nano gamma-ferric oxide/ polyaniline-dexamethasone sodium phosphate

A technology of dexamethasone sodium phosphate and conductive nanometers, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve industrial production and application, good electrical conductivity and magnetic conductivity, and good electrochemistry active effect

Inactive Publication Date: 2011-04-06
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, large doses can easily cause diabetes, peptic ulcer, Cushing's syndrome-like symptoms, inhibition of the hypothalamus-pituitary-adrenal axis, and many other side effects

Method used

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  • Preparation method of superparamagnetism conductive nano gamma-ferric oxide/ polyaniline-dexamethasone sodium phosphate
  • Preparation method of superparamagnetism conductive nano gamma-ferric oxide/ polyaniline-dexamethasone sodium phosphate
  • Preparation method of superparamagnetism conductive nano gamma-ferric oxide/ polyaniline-dexamethasone sodium phosphate

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Embodiment Construction

[0017] Introduced below are the structural characterizations as the above-mentioned specific examples of the present invention, and thus the above-mentioned content of the present invention can be further explained. Specific examples include infrared, energy spectrum, transmission electron microscopy, magnetization with external magnetic field, and conductivity measurement of the product, but this should not be construed as being limited to the following examples within the scope of the above-mentioned subject of the present invention.

[0018] One, the principle of preparing superparamagnetic conductive nano gamma-iron oxide / polyaniline-dexamethasone sodium phosphate is as follows:

[0019]

[0020] 2. Preparation process

[0021] 1. Raw materials: aniline (distilled under reduced pressure to colorless and stored in a refrigerator at 4°C for later use), hydrochloric acid, sulfuric acid, camphorsulfonic acid, ammonia water, ammonium persulfate, ferrous sulfate heptahydrate,...

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Abstract

The invention discloses a preparation method of superparamagnetism conductive nano gamma-ferric oxide / polyaniline-dexamethasone sodium phosphate, relating to the technical field of synthesis of superparamagnetism conductive nano gamma-ferric oxide / polyaniline-dexamethasone sodium phosphate. The superparamagnetism conductive nano gamma-ferric oxide / polyaniline-dexamethasone sodium phosphate is prepared by a doping method. The product of the invention can better suspend in water, still has favorable electrochemical activity and electric conduction magnetoconductivity within the pH range of human body environment, and can directionally reach diseased tissues under the regulation and control of an external magnetic field without damaging normal clasmatocyte. The targeted medicine is hopefully applied to treating acute leukemia, malignant lymphoma, connective tissue diseases, rheumatoid arthritis and the like. In addition, the method of the invention is simple, convenient, economical and favourable for industrial production and application.

Description

technical field [0001] The invention relates to the technical field of synthesizing superparamagnetic conductive nano-γ-iron oxide / polyaniline-dexamethasone sodium phosphate. Background technique [0002] In clinical medicine, chemotherapy is one of the important methods to treat tumor diseases. The biggest disadvantage of commonly used chemotherapy methods is that they are not selective and damage normal cells while killing tumor tissues. The way to overcome its shortcomings is to realize targeted therapy. The methods of targeted therapy proposed by researchers so far include: gene-virus targeted therapy, RNA targeted therapy, monoclonal antibody targeted therapy and enzyme targeted therapy. Although these treatment methods have improved the effect of commonly used chemotherapy, it is still difficult to truly meet the requirements of targeted therapy and make the drug work only in the lesion tissue area. Therefore, it remains to be further explored to find a stable drug ...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K47/02A61K31/661A61K31/573A61P19/04A61P19/02A61P29/00A61P35/00A61P35/02
Inventor 阚锦晴郭晓霞
Owner YANGZHOU UNIV
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