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Veterinary compound sulfadiazine sodium injection and preparation method thereof

A technology of sulfadiazine sodium and injection, which is applied in the field of veterinary compound sulfadiazine sodium injection, can solve the problems of incomplete curative effect, achieve the effect of relieving the surface symptoms of livestock and poultry, preventing mixed infection, and convenient administration

Inactive Publication Date: 2010-09-15
陈建波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dose of the injection is accurate and the effect is reliable, unlike the internal medicine that may be affected by digestive juices, food, etc., and the dose used cannot fully produce the curative effect

Method used

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  • Veterinary compound sulfadiazine sodium injection and preparation method thereof
  • Veterinary compound sulfadiazine sodium injection and preparation method thereof
  • Veterinary compound sulfadiazine sodium injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A compound sulfadiazine sodium injection for veterinary use, the components are as follows:

[0038] Sulfadiazine sodium 10g, enrofloxacin 10g, trimethoprim 4.5g, flunixin meglumine 0.5g, dexamethasone sodium phosphate 0.05g, sodium thiosulfate 0.15g, edetate disodium 0.04 g, benzyl alcohol 20g, N,N-dimethylformamide 50g, water for injection 20g;

[0039] The veterinary compound sulfadiazine sodium injection is prepared by the following steps:

[0040] 1) Dissolve 0.5 g of flunixin meglumine, 0.05 g of dexamethasone sodium phosphate, 0.15 g of sodium thiosulfate, 0.04 g of disodium edetate, and 10 g of sulfadiazine sodium in 20 g of water for injection, and mix solution;

[0041] 2) dissolving 10 g of enrofloxacin in 20 g of benzyl alcohol to obtain a solution of enrofloxacin;

[0042] 3) Dissolving 4.5 g of trimethoprim in 50 g of N,N-dimethylformamide to obtain a trimethoprim solution;

[0043] 4) Mix the mixed solution solution prepared in step 1), the enrofloxac...

Embodiment 2

[0062] A compound sulfadiazine sodium injection for veterinary use, the components are as follows:

[0063] Sulfadiazine sodium 5g, enrofloxacin 15g, trimethoprim 2-8g, flunixin meglumine 0.3g, dexamethasone sodium phosphate 0.02g, sodium thiosulfate 0.1g, edetate disodium 0.03g, 10g benzyl alcohol, 45g N,N-dimethylformamide, 30g water for injection;

[0064] The preparation steps were the same as in Example 1 to obtain compound sulfadiazine sodium injection for veterinary use, with a pH of 9.5.

[0065] Table 1 clinical treatment effect of the present invention

[0066]

[0067] Table 2 The present invention and sulfadiazine sodium injection clinical treatment comparative test result

[0068]

[0069]

[0070] The stability test of product is with embodiment 1.

[0071]

[0072]

[0073] As can be seen from the above data, the product of this embodiment has no obvious change in product color after 3 months of product acceleration test, and is a...

Embodiment 3

[0075] A compound sulfadiazine sodium injection for veterinary use, the components are as follows:

[0076] Sulfadiazine sodium 7g, enrofloxacin 13g, trimethoprim 4g, flunixin meglumine 0.35g, dexamethasone sodium phosphate 0.05g, sodium thiosulfate 0.15g, edetate disodium 0.03g , benzyl alcohol 15g, N,N-dimethylformamide 45g, water for injection 30g;

[0077] The preparation steps were the same as in Example 1 to obtain compound sulfadiazine sodium injection for veterinary use, with a pH of 9.7.

[0078] Table 1 clinical treatment effect of the present invention

[0079]

[0080] Table 2 The present invention and sulfadiazine sodium injection clinical treatment comparative test result

[0081]

[0082]

[0083] The stability test of product is with embodiment 1.

[0084]

[0085] As can be seen from the above data, the product of this embodiment has no obvious change in product color after 3 months of product acceleration test, and is all within the spec...

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PUM

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Abstract

The invention relates to a veterinary compound sulfadiazine sodium injection and a preparation method thereof. The veterinary compound sulfadiazine sodium injection comprises sulfadiazine sodium, enrofloxacin, flunixin meglumine, trimethoprim, dexamethasone sodium phosphate, an organic solvent and water for injection. The injection serving as a veterinary special compound preparation has a special treating effect on various infectious diseases, mixed infections and systemic infections of the digestive system, the respiratory system, the urinary system and the skin soft tissue caused by sensitive bacteria and mycoplasmas of oxen, swines, poultries, canines, cats and aquatic animals The injection has the advantages of convenient use, short period of treatment, low medicament resistance and the like.

Description

technical field [0001] The invention relates to a veterinary compound sulfadiazine sodium injection, in particular to an injection made of sulfadiazine sodium, enrofloxacin, flunixin meglumine, trimethoprim and dexamethasone sodium phosphate and its preparation method. Background technique [0002] Sulfadiazine sodium (Sulfadiazine Sodium) has strong antibacterial power, high curative effect on various infections, and small side effects. It is a variety with strong antibacterial effect among sulfonamides. , Escherichia coli, etc., have strong effects on respiratory tract and digestive tract infections caused by sensitive bacteria. It can also be used to treat systemic infections. Sulfadiazine sodium is the drug of choice in the treatment of brain infections in this class of drugs. For viral infections such as encephalitis that is prevalent in livestock, using this product can effectively prevent mixed infections. [0003] Enrofloxacin, a representative of the new generati...

Claims

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Application Information

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IPC IPC(8): A61K31/661A61K31/635A61K31/496A61K31/505A61K31/44A61K9/08A61P31/04
Inventor 陈建波陈抗
Owner 陈建波
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