Compound doxycycline hydrochloride injection for animals and preparation method thereof

A technique for doxycycline hydrochloride and injection, which is applied in the field of veterinary compound doxycycline hydrochloride injection and its preparation, can solve the problems that the curative effect cannot be fully produced, and achieve long action time, low drug resistance, and long course of treatment. short effect

Inactive Publication Date: 2009-03-11
陈建波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage of the injection is accurate and the effect is reliable, unlike the oral medicine that may be

Method used

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  • Compound doxycycline hydrochloride injection for animals and preparation method thereof
  • Compound doxycycline hydrochloride injection for animals and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A compound doxycycline hydrochloride injection for veterinary use contains the following components:

[0032] Doxycycline hydrochloride 5g, thiamphenicol 8g, trimethoprim 3.25g, diclofenac sodium 3g, dexamethasone sodium phosphate 0.05g, magnesium chloride 2.35g, sodium formaldehyde sulfoxylate 0.25g, sodium thiosulfate 0.15 g, 30g of α-pyrrolidone, 38g of N,N-dimethylformamide, 16g of water for injection; 2.4g of ethanolamine, a pH regulator, is required during the preparation process.

[0033] The preparation method of the veterinary compound doxycycline hydrochloride injection, the steps are as follows:

[0034] 1) After dissolving magnesium chloride in 8 g of water for injection, add 30 g of α-pyrrolidone, then add 5 g of doxycycline hydrochloride, and stir to dissolve;

[0035] 2) After dissolving sodium formaldehyde sulfoxylate in 3 g of water for injection, add it to the solution prepared in step 1), and then add 2 g of ethanolamine;

[0036] 3) After dissolvin...

Embodiment 2

[0052] A kind of veterinary compound doxycycline hydrochloride injection, raw material components are as follows:

[0053] Doxycycline hydrochloride 7g, thiamphenicol 10g, trimethoprim 4.3g, diclofenac sodium 4g, dexamethasone sodium phosphate 0.07g, magnesium chloride 3.3g, sodium formaldehyde sulfoxylate 0.5, sodium thiosulfate 0.20g , 35g of α-pyrrolidone, 40g of N,N-dimethylformamide, 10g of water for injection; 3g of ethanolamine, a pH regulator, is required during the preparation process.

[0054] The preparation steps are the same as in Example 1.

Embodiment 3

[0056] A compound doxycycline hydrochloride injection for veterinary use contains the following components:

[0057] Doxycycline hydrochloride 3g, thiamphenicol 6g, TMP1.6g, diclofenac sodium 2g, dexamethasone sodium phosphate 0.03g, magnesium chloride 1.4g, sodium formaldehyde sulfoxylate 0.1g, sodium thiosulfate 0.10g, α - 25g of pyrrolidone, 45g of N,N-dimethylformamide, 20g of water for injection; 1.5g of ethanolamine, a pH regulator, is required during the preparation process.

[0058] The preparation steps are the same as in Example 1.

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PUM

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Abstract

The invention relates to a compound doxycycline hydrochloride injection for veterinary use and a preparation method thereof. The raw materials comprise doxycycline hydrochloride, thiamphenicol, dexamethasone sodium phosphate, trimethoprim, diclofenac sodium, organic solvent and water for injection. As a special compound preparation for veterinary use, the injection has obvious curative effects on infectious diseases caused by gram-positive bacteria, gram-negative bacteria and mycoplasma, quickly takes effects after the injection is injected into livestock with the diseases, and has special efficacy on mixed infection and severe diseases caused by various pathogenic bacteria and viruses. After intramascular for animals, the injection is easily absorbed, takes effect for a long time and causes little local stimulation. The injection has the advantages of convenient use, short treatment course, low drug resistance, and the like.

Description

technical field [0001] The invention relates to a veterinary compound doxycycline hydrochloride injection and a preparation method thereof, belonging to the technical field of veterinary medicines. Background technique [0002] 1. At present, there is a high incidence of mixed infection of livestock and poultry, serious complications, mixed infection caused by various germs and viruses, and a high incidence of critical illness. The market urgently needs to relieve complications and fundamentally play a bactericidal role. One injection can be effective Drugs with good therapeutic effects. [0003] 2. At present, in clinical use, doxycycline hydrochloride and thiamphenicol have obvious advantages in antibacterial aspects, especially when used in conjunction with synergistic factors, the effect is better, and it is effective against fever and pain caused by bacteria and viral infections and other superficial symptoms, supplemented by antipyretic and analgesic drugs and dexamet...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/65A61K31/16A61K31/505A61K31/196A61K31/661A61P31/00A61P29/00
Inventor 陈建波
Owner 陈建波
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