Compound ofloxacin injection for animals for treating postnatal infection and preparation method thereof

A compound ofloxacin, postpartum infection technology, applied in the directions of medical preparations containing active ingredients, devices for making medicines into special physical or taking forms, pharmaceutical formulas, etc. , treatment of inconvenience and other problems, to achieve the effect of treating indigestion, speeding up postpartum recovery, and promoting gastrointestinal motility

Inactive Publication Date: 2009-12-30
天津市海纳德动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the widespread emergence of bacterial drug resistance in recent years, a single antibacterial drug often cannot produce good therapeutic effects due to drug resistance, and the uterine contents such as placenta, lochia, and post-infection inflammatory products cannot be discharg

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Weigh 0.5 kg ofloxacin and put it into 25 L of water for injection, then add 1000 ml of hydrochloric acid with a volume percentage concentration of 37.5%, and stir until completely dissolved.

[0023] (2) Put 15 billion units of kanamycin sulfate into 50 L of water for injection at about 80°C, and stir until completely dissolved.

[0024] (3) Take 5 L of water for injection, dissolve 0.1 kg of bethanechol ammonium chloride, and 0.06 kg of dexamethasone sodium phosphate.

[0025] (4) Combine the solutions prepared in step (1), step (2) and step (3), then add water for injection to 100L, stir evenly, keep for 15-20min, use a volume percentage concentration of 20% hydrochloric acid solution or mass The sodium hydroxide solution with a percentage concentration of 40% is used to adjust the pH value to 4.22, and the compound ofloxacin injection for veterinary treatment of postpartum infection of the present invention is prepared after the liquid is clarified.

Embodiment 2

[0027] (1) Weigh 10 kg ofloxacin and put it into 25 L of water for injection, then add 1000 ml of hydrochloric acid with a volume percentage concentration of 37.5%, and stir until completely dissolved.

[0028] (2) Put 3 billion units of kanamycin sulfate into 50 L of water for injection at about 80°C, and stir until completely dissolved.

[0029] (3) Take 5 L of water for injection, dissolve 0.02 kg of bethanechol ammonium chloride, and 0.06 kg of dexamethasone sodium phosphate.

[0030] (4) Combine the solutions prepared in step (1), step (2) and step (3), then add water for injection to 100L, stir evenly, keep for 15-20min, use a volume percentage concentration of 20% hydrochloric acid solution or mass The sodium hydroxide solution with a percentage concentration of 40% adjusts the pH value to 4.15, and the compound ofloxacin injection for veterinary treatment of postpartum infection of the present invention is prepared after the liquid is clarified.

Embodiment 3

[0032] (1) Weigh 1 kg ofloxacin and put it into 25 L of water for injection, then add 1000 ml of hydrochloric acid with a volume percentage concentration of 37.5%, and stir until completely dissolved.

[0033] (2) Put 10 billion units of kanamycin sulfate into 50 L of water for injection at about 80°C, and stir until completely dissolved.

[0034] (3) Take 5 L of water for injection, dissolve 0.08 kg of bethanechol ammonium chloride, and 0.06 kg of dexamethasone sodium phosphate.

[0035] (4) Combine the solutions prepared in step (1), step (2) and step (3), then add water for injection to 100L, stir evenly, keep for 15-20min, use a volume percentage concentration of 20% hydrochloric acid solution or mass The sodium hydroxide solution with a percentage concentration of 40% adjusts the pH value to 4.33, and the compound ofloxacin injection for veterinary treatment of postpartum infection of the present invention is prepared after the liquid is clarified.

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PUM

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Abstract

The invention discloses a compound ofloxacin injection for animals for treating postnatal infection and a preparation method thereof. The invention aims to provide a compound ofloxacin injection for the animals which has quick response on treating the postnatal infection of livestock, is effective and efficient and can treat both principal and secondary aspects of diseases, and a preparation method thereof. Each 100L of injection comprises the following components: 0.5 to 10kg of ofloxacin, 3 to 15 of billion units of kanamycin sulfate, 0.06kg of dexamethasone sodium phosphate, 0.02 to 0.1kg of bethanechol chloride, 1,000ml of hydrochloric acid, and the balance of water for injection. The injection has double functions of bacteria inhibition and sterilization by using the ofloxacin in combination with the kanamycin sulfate, reduces the probability that bacteria produce the drug resistance, and increases the sensitivity of the bacteria; in addition, the dexamethasone sodium phosphate has anti-inflammatory, detoxicating and antiallergic functions; and the bethanechol chloride stimulates the intestines and stomach as well as uterine smooth muscle to creep. The product treats both principal and secondary aspects of diseases on the postnatal infection of dams and complicating diseases thereof, and can accelerate the postpartum recovery of the dams.

Description

technical field [0001] The invention relates to a compound ofloxacin injection for veterinary treatment of postpartum infection and a preparation method thereof. Background technique [0002] Postpartum infection of livestock is a common disease. The main reason is bacterial infection caused by improper care or decreased resistance of the female animal after childbirth. If it does not fall, it will cause further deterioration and severe inflammation will appear, and clinically it will also show characteristics such as loss of appetite and constipation. [0003] The treatment of this disease requires antibacterial and anti-inflammatory, and symptomatic treatment. Due to the widespread emergence of bacterial drug resistance in recent years, a single antibacterial drug often cannot produce good therapeutic effects due to drug resistance, and the uterine contents such as placenta, lochia, and post-infection inflammatory products cannot be discharged normally after delivery, res...

Claims

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Application Information

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IPC IPC(8): A61K31/7036A61K31/5383A61K31/661A61K31/27A61K9/08A61J3/00A61P31/04A61P1/14A61P1/10
Inventor 徐克福
Owner 天津市海纳德动物药业有限公司
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