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Preparation process for cefoperazone sodium and tazobactam sodium for injection

A technology for cefoperazone sodium and tazobactam sodium is applied in the field of medicine and can solve the problems of complex development and production process of injections, poor safety and body applicability, etc.

Inactive Publication Date: 2012-06-27
SUZHOU ERYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At the same time, the development and production process of injections is complicated; the shortcomings of safety and poor applicability to the body

Method used

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  • Preparation process for cefoperazone sodium and tazobactam sodium for injection

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Embodiment Construction

[0023] The solutions of the present invention will be further described below in conjunction with specific examples. For the convenience of expression, the compounds mentioned are represented by their common names.

[0024] (1) Prescription

[0025]

[0026] (2) Preparation process

[0027] 1. Mixed powder of cefoperazone sodium and tazobactam sodium:

[0028] Remove the outer packaging of sterile raw materials at the elevator entrance, transport them to the transfer window of raw materials, wipe them with 75% ethanol solution, and disinfect them with ozone for 60 minutes, then take them out from the sterile side, wipe them again with 75% ethanol solution, and put them away. storage room.

[0029] Receive raw materials according to the batch mixing instructions, and check the product name, batch number, weight, and inspection order number.

[0030] Under 100-level laminar flow, mix cefoperazone sodium and tazobactam sodium at a ratio of 1:0.125.

[0031] After the addi...

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PUM

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Abstract

A preparation process for cefoperazone sodium and tazobactam sodium for injection is disclosed, which comprises the following steps of: (1) mixing for cefoperazone sodium powder and tazobactam sodium powder; (2) cleaning for bottle: straightening a bottle, cleaning the bottle by an ultrasonic wave, and sterilizing by dry heat in a tunnel drying oven; (3) cleaning for stopper: cleaning a rubber stopper, sterilizing and drying; (4) sterile subpackaging; (5) treatment for aluminium cap; (6) lamp inspection for capping; (7) labelling; and (8) boxing.

Description

[0001] technical field [0002] The invention relates to the field of medicine, in particular to a preparation process of cefoperazone sodium and tazobactam sodium for injection. Background technique [0003] In recent years, the average annual growth rate of the world's antibiotic market is about 8%, and the global antibiotic market share is about 25 billion to 26 billion US dollars. Major pharmaceutical companies have invested huge sums of money in the research and development of antibiotic drugs, so that new antibiotic products continue to emerge. In the Chinese pharmaceutical market, anti-infective drugs have ranked first in sales for many years, with annual sales of more than 20 billion yuan, accounting for 30% of the national drug sales. [0004] Cefoperazone is the third-generation broad-spectrum semi-synthetic cephalosporin, which can resist the degradation of various β-lactamases, has a wide antibacterial spectrum, and is effective against both Gram-positive and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/546A61P31/04A61K31/431
Inventor 颜彦陆夕明张瑜
Owner SUZHOU ERYE PHARMA CO LTD
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