Beta-lactam compound antibiotic composition

A technology of antibiotics and compositions, applied in the field of compound antibiotic compositions, to achieve the effects of improved product quality yield, improved fluidity, and strong antibacterial effect

Active Publication Date: 2012-01-25
SINOPHARM ZHIJUN (SHENZHEN) PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Regarding whether the fluidity of the composition powder of cefuroxime and its salt and tazobactam sodium can be improved by various means, so that the efficiency of drug dispensing can be directly increased, and the stability and convenience of the production of the preparation can be improved , the current prior art does not pay attention to this problem, and no effective solution has been proposed

Method used

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  • Beta-lactam compound antibiotic composition

Examples

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Embodiment 1

[0023] The β-lactam compound antibiotic composition of the present invention contains cefuroxime and tazobactam sodium monohydrate, and the weight ratio of the two components is 1: 1 (tazobactam sodium monohydrate according to other Zobactam meter).

[0024] The above-mentioned β-lactam compound antibiotic composition is prepared by the following method: cefuroxime powder and tazobactam sodium monohydrate that can be sieved through a 70-mesh sieve are put into KENWOOD-KM600 omnipotent mixer from UK Kenwood, time 20 minutes, rotating speed 20 rpm, production environment temperature 18°C ​​to 26°C, humidity 45% to 65% (refer to the GMP regulation of pharmaceutical production quality management) The mixture is the β-lactam compound antibiotic composition of the present invention.

Embodiment 2

[0026] The β-lactam compound antibiotic composition of the present invention contains cefuroxime sodium and tazobactam sodium monohydrate, and the weight ratio of the two components is 2: 1 (calculated as cefuroxime for cefuroxime sodium) , tazobactam sodium monohydrate is calculated as tazobactam).

[0027] The preparation method is the same as in Example 1.

Embodiment 3

[0029] The β-lactam compound antibiotic composition of the present invention contains cefuroxime potassium and tazobactam sodium monohydrate, and the weight ratio of the two components is 3: 1 (calculated for cefuroxime potassium as cefuroxime) , tazobactam sodium monohydrate is calculated as tazobactam).

[0030] The preparation method is the same as in Example 1.

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Abstract

The invention provides a beta-lactam compound antibiotic composition, which contains cefuroxime and a tazobactam sodium monohydrate, or cefuroxime salts and the tazobactam sodium monohydrate, wherein the weight ratio of the cefuroxime salts counted according to the cefuroxime to the tazobactam sodium monohydrate counted according to the tazobactam is (1-8):1. The beta-lactam compound antibiotic composition disclosed by the invention is used for being prepared into a clinically-acceptable medicinal preparation with the cefuroxime and salts thereof as well as the tazobactam sodium monohydrate as active components. According to the beta-lactam compound antibiotic composition, the tazobactam sodium monohydrate is mixed with the cefuroxime and salts thereof so as to improve the flowability of composition powder, enable the uniformity of the medicament to be better in the production process and improve the yield of the product; and the beta-lactam compound antibiotic composition has saved production cost and is especially suitable for popularization and application.

Description

technical field [0001] The invention relates to a β-lactam compound antibiotic composition, in particular to a compound antibiotic composition containing cefuroxime and its salt and tazobactam sodium monohydrate. Background technique [0002] At present, the largest class of antibiotics used clinically is β-lactam antibiotics, commonly used are penicillins, cephalosporins, cephamycins and other varieties. Among them, compared with traditional penicillins, cephalosporin antibiotics have the advantages of relatively stable structure and low allergic reaction, so they develop most rapidly. At present, there have been four generations of cephalosporin antibiotics. The representative products commonly used in clinical practice, such as cefuroxime, belong to the second-generation cephalosporins and have broad-spectrum antibacterial effects. And most negative bacteria have a strong antibacterial effect, also have a certain effect on anaerobic bacteria, and are widely distributed i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K31/431A61P31/04
CPCA61K31/546A61K31/43A61K9/14A61K9/0019A61P31/04A61K2300/00
Inventor 邓宝军黄艳陈有和曾环想丁梅张彧曹明兰权超
Owner SINOPHARM ZHIJUN (SHENZHEN) PHARMA CO LTD
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