30 results about "Lignocaine hydrochloride" patented technology

The invention discloses an injection containing glucosamine sulfate double salt, the active ingredients of which are glucosamine sulfate double salt and lidocaine hydrochloride. The injection described in the invention is preferably a small-volume injection, and the injection further includes antioxidants, pH regulator and alkaline solvent, the injection of the present invention overcomes the long freeze-drying time of the freeze-dried preparation of glucosamine in the prior art, high energy consumption, and is unfavorable for production, and the freeze-dried preparation of the same batch is different in form and recombination. The defect that there is a large difference in solubility has realized the control of the stability of the injection and related substances, and reduced the side effects caused by the degradation products, thereby meeting the requirements of the safety and stability of the injection. Therefore, the amino acid provided by the present invention The glucose injection can satisfy industrial production, and can be safely and reliably applied in the field of medicine.

The invention provides a preparation method of lidocaine hydrochloride, which belongs to the technical field of anesthetic synthesis. The preparation method uses 2.6-xylenol as a raw material, adopts Pd / C as the main catalyst, 2,6-dimethylcyclohexanone as a co-catalyst, and performs liquid-phase amination with ammonia water at high temperature to obtain the intermediate 2,6 -Dimethylaniline; then use sodium methoxide, 2,6-dimethylaniline and N,N-diethylaminoacetate methyl ester as raw materials, react at 90-95°C, distill and remove methanol while reacting until it is free After the methanol is distilled off, continue to react for 30 minutes, cool to room temperature, add dichloroethane, wash with water, leave to stand and separate, the organic layer is the dichloroethane solution of lidocaine base; Add hydrochloric acid to the ethyl chloride solution, then adjust the pH to 3.5-4 with hydrogen chloride, add activated carbon to reflux for 20-40 minutes, filter, and the filtrate is concentrated, crystallized by cooling, and dried to obtain lidocaine hydrochloride. The lidocaine hydrochloride of the present invention has a simple synthesis process, a product purity of more than 99%, and a total yield of more than 84%.

The invention discloses an external gel for skin wounds. The external gel is prepared from the following raw materials in parts by weight: 1-3 parts of an active component A, 4-6 parts of an active component B, 10-14 parts of a Calendula arvensis extract, 16-20 parts of a Centella asiatica extract, and 60-80 parts of an auxiliary material, wherein the active component A is at least two of polymyxin B sulfate, neomycin sulfate and bacitracin, the active component B is at least one of lidocaine hydrochloride, pramoxine hydrochloride, procaine hydrochloride and menthol, and the auxiliary materialcomprises the following raw materials in parts by weight: 0.5-3 parts of carbomer, 40-75 parts of an organic solvent, and 20-50 parts of purified water. The external gel provided by the invention hasprevention and treatment effects on the bacterial infection of skin wound parts, has analgesic and hemostatic effects on skin wounds, can promote the formation of capillaries and collagenous fibers of wound surfaces, reduces the healing days of wound surfaces, and can be used for the healing of skin wounds such as burn wounds, incised wounds and scald wounds, the healed skin is smooth and free ofscars, and thereby the healing effect is good.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to research on a lidocaine hydrochloride sterilization process and a packing material. According to the lidocaine hydrochloride injection disclosed by the invention, the polypropylene plastic ampoule is used as a packing material of the lidocaine hydrochloride injection, and the sterilization process is that superheated water is sterilized for 15 minutes at 121 DEG C. The product quality is stable, the problems caused by the glass ampoule can be well solved, the clinical configuration process is optimized, and the lidocaine hydrochloride injection is convenient to transport and meets the environmental protection requirement.

The invention relates to the technical field of medical materials, in particular to an implant material capable of being used for human body soft tissue filling. In order to solve the problems that in the prior art, the degradation speed is high, displacement is likely to occur, the filling effect cannot be well kept, and repeated injection filling is needed, the implant material capable of being used for human body soft tissue filling is provided and comprises sodium hyaluronate, bioactive inorganic silicate, lidocaine hydrochloride and dexamethasone. Cross-linked sodium hyaluronate gel is used as an implantation carrier, bioactive inorganic silicate particle components are compounded, and medicines such as lidocaine hydrochloride and dexamethasone are matched and injected into collapsed soft tissues needing to be filled, so that the collapsed soft tissues of a patient are recovered; through the physical properties of the cross-linked sodium hyaluronate and the bioactive inorganic silicate particles and the excellent biocompatibility, the degradation time can be greatly prolonged and is 5-8 times of the degradation time of the sodium hyaluronate gel in the prior art, and the filling effect can be kept for a long time.

The invention provides a medicine composite used for embolotherapy and acesodyne and a preparation method thereof. The medicine composite comprises a biocompatibility macromolecular compound containing hydroxy, a monomer containing unsaturated double bond and anion group, a polymer, and local anesthetic containing amino group, wherein the polymer is generated through a polymerization reaction of an optional vinyl monomer and the polymerization reaction is initiated by free radicals, and the local anesthetic is combined to an anion group of the generated polymer. In the invention, lidocaine hydrochloride is combined to a polymer carrier; which can give full play to the acesodyne effect of the local anesthetic in the embolotherapy; the anion part of the polymer can properly combine with the local anesthetic containing the amino group, which can both realize higher medicine loading capacity and enable the medicine in an emboliaztion agent to be exchanged by cations in vivo and then slowly released. Moreover, the polymer emboliaztion carrier has simple technology, low cost, and suitability for large scale industrial production.

The invention discloses a production method and application of lidocaine hydrochloride, wherein the production method comprises the steps: carrying out acylation reaction on 2,6-dimethylaniline and chloroacetyl chloride to obtain a chloroacetyl compound, carrying out condensation reaction on the chloroacetyl compound and diethylamine to obtain lidocaine, and reacting lidocaine with hydrogen chloride gas to obtain a lidocaine hydrochloride crude product; refining the lidocaine hydrochloride crude product to obtain lidocaine hydrochloride, wherein solvents adopted in the acylation reaction and the condensation reaction are toluene, solvents of lidocaine and hydrogen chloride gas are acetone, and a refined solvent system is acetone and water; and after the condensation reaction, extracting the material with an acid solution, adding activated carbon for adsorption, filtering to remove the activated carbon, and adding an alkaline solution for treatment to obtain lidocaine. According to themethod, impurities of lidocaine hydrochloride can be greatly reduced, so that the safety and effectiveness of the lidocaine hydrochloride product are improved.

A radionuclide contamination decontamination agent and its preparation method and application, the decontamination agent comprises the following components in mass percentage: EDTA·Na 2 : 1.0%‑20%, carboxymethyl chitosan: 0.1%‑0.4%, sodium alginate: 0.05%‑0.3%, lidocaine hydrochloride: 0.5%‑2.0%, the rest is pure water or phosphate buffer, The pH is 6.9‑7.0. It also provides its preparation method: accurately weigh EDTA‑Na in proportion 2 , carboxymethyl chitosan, sodium alginate and lidocaine hydrochloride, EDTA‑Na 2 Heat to dissolve under alkaline conditions, then dissolve carboxymethyl chitosan and sodium alginate, then mix the two, stir evenly, then add lidocaine hydrochloride solution, use HCl to adjust the pH to 6.7‑6.9, stir to dissolve ,Volume. The decontamination agent of the invention has the function of chelating and adsorbing various radionuclides, has no toxic and side effects, and can be used as a low-toxicity and high-efficiency radionuclide pollution decontamination agent.

The invention relates to a drug rehabilitation preparation and method for preparation, wherein the preparation comprises predetermined amount of tetrodontoxin monomer as the main effective composition, right amount of auxiliary material carrier, function modifier and tetrodontoxin derivative as the stabilizer, the acidic dissolvent carrier is selected from acetic acid / sodium acetate, or citric acid / sodium citrate, or citric acid / disodium hydrogen phosphate, the function modifier is at least one selected from trichlorbutanolum, benzoic alcohol and lignocaine hydrochloride.

The invention provides compound lidocaine nano-liposome gel and a preparation method thereof. The nano-liposome gel is prepared from the following raw materials: lidocaine hydrochloride, tetracaine hydrochloride, tetracaine base, lidocaine base, dyclonine hydrochloride, procaine hydrochloride, soyabean lecithin, cholesterol, xanthan gum, carbomer and sodium carboxymethyl cellulose. The preparationmethod of the nano-liposome gel comprises the following steps: S1, preparing raw materials; s2, mixing soyabean lecithin and cholesterol to obtain a mixture A; s3, dissolving carbomer to obtain a mixture B; and S4, adding lidocaine hydrochloride, tetracaine hydrochloride, dyclonine hydrochloride, procaine hydrochloride and the mixture B into the mixture A, performing stirring, adding tetracaine alkali and lidocaine alkali, performing cooling, adding xanthan gum and sodium carboxymethyl cellulose, performing stirring, and performing homogenizing to obtain the compound lidocaine nano-liposome gel. The nano-liposome gel provided by the invention is good in stability in a normal-temperature state and a low-temperature state.

The object of the present invention is a method for obtaining injectable hydrogels based on hyaluronic acid containing lidocaine hydrochloride and alkaline agents added in powder or solution form, said hydrogels being heat sterilized, having a transparent The hyaluronic acid concentration and flow properties were equivalent to the corresponding hydrogels based on hyaluronic acid without any lidocaine hydrochloride. The present invention also relates to various uses of the aforementioned hydrogels.

The invention relates to the field of Chinese and Western medicine compound preparations, and specifically discloses a compound Chinese and Western medicine mixture for children with stomatitis and a preparation method thereof. Its prescription is composed of the following ingredients: flea 2g-4g, shegan 3g-5g, white fresh skin 3g-5g, angelica dahurica 0.5g-2g, Qingdai 0.5g-2g, root ginseng 0.3g-3g, borax 0.5g g-3g, cinnabar 0.05g-1g, borneol 0.02g-2g, gentamicin 80,000 units-160,000 units, lidocaine hydrochloride 0.05g-0.1g. Its preparation method is: according to the proportion of the above-mentioned Chinese medicine components, select pure and high-quality herbal medicine decoction pieces, remove impurities, first grind the other eight Chinese medicine raw materials except cinnabar into 120-160 mesh fine powder, and then grind the cinnabar to a fineness of 120-160 mesh No friction is the degree, dry it into a block, then mix the ground cinnabar with the previously developed Chinese medicine ingredients evenly, put it in a light-proof sealed container, and add gentamicin according to the proportion in the formula when it is used Sodium glutamate, lidocaine hydrochloride and an appropriate amount of 0.9% physiological saline are mixed uniformly to make an external water agent that can be sprayed. The present invention has high curative effect and short course of treatment, is an external spraying medicament, can be sprayed, is convenient for children to use, and has obvious advantages compared with existing medicines and treatments.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses lidocaine hydrochloride gel and a preparation method thereof. The gel is prepared from the following components in percentage by mass of 11 percent to 13 percent of poloxamer 407, 0.1 percent to 0.5 percent of poloxamer 188 and 86.5 percent to 88.5 percent of nanoemulsion, wherein the nanoemulsion is prepared from the following components in percentage by mass of 2 percent to 5 percent of an oil phase, 15 percent to 23 percent of a surfactant, 5 percent to 10 percent of a cosurfactant, 60 percent to 70 percent of deionized water and 2 percent of lidocaine hydrochloride on the basis that the total amount of the components is 100 percent. According to the gel, lidocaine hydrochloride is dispersed in the nanoemulsion, a gel matrix with a temperature-sensitive characteristic is formed by poloxamer 407 and poloxamer 188 according to a specific ratio, and the nanoemulsion is loaded on the gel matrix to form the nano-emulsion-in-situ gel which has a long-acting analgesic effect.