30 results about "Lignocaine hydrochloride" patented technology

The invention provides a preparation method of lidocaine hydrochloride, which belongs to the technical field of anesthetic synthesis. The preparation method uses 2.6-xylenol as a raw material, adopts Pd / C as the main catalyst, 2,6-dimethylcyclohexanone as a co-catalyst, and performs liquid-phase amination with ammonia water at high temperature to obtain the intermediate 2,6 -Dimethylaniline; then use sodium methoxide, 2,6-dimethylaniline and N,N-diethylaminoacetate methyl ester as raw materials, react at 90-95°C, distill and remove methanol while reacting until it is free After the methanol is distilled off, continue to react for 30 minutes, cool to room temperature, add dichloroethane, wash with water, leave to stand and separate, the organic layer is the dichloroethane solution of lidocaine base; Add hydrochloric acid to the ethyl chloride solution, then adjust the pH to 3.5-4 with hydrogen chloride, add activated carbon to reflux for 20-40 minutes, filter, and the filtrate is concentrated, crystallized by cooling, and dried to obtain lidocaine hydrochloride. The lidocaine hydrochloride of the present invention has a simple synthesis process, a product purity of more than 99%, and a total yield of more than 84%.

The invention provides a medicine composite used for embolotherapy and acesodyne and a preparation method thereof. The medicine composite comprises a biocompatibility macromolecular compound containing hydroxy, a monomer containing unsaturated double bond and anion group, a polymer, and local anesthetic containing amino group, wherein the polymer is generated through a polymerization reaction of an optional vinyl monomer and the polymerization reaction is initiated by free radicals, and the local anesthetic is combined to an anion group of the generated polymer. In the invention, lidocaine hydrochloride is combined to a polymer carrier; which can give full play to the acesodyne effect of the local anesthetic in the embolotherapy; the anion part of the polymer can properly combine with the local anesthetic containing the amino group, which can both realize higher medicine loading capacity and enable the medicine in an emboliaztion agent to be exchanged by cations in vivo and then slowly released. Moreover, the polymer emboliaztion carrier has simple technology, low cost, and suitability for large scale industrial production.

A radionuclide contamination decontamination agent and its preparation method and application, the decontamination agent comprises the following components in mass percentage: EDTA·Na 2 : 1.0%‑20%, carboxymethyl chitosan: 0.1%‑0.4%, sodium alginate: 0.05%‑0.3%, lidocaine hydrochloride: 0.5%‑2.0%, the rest is pure water or phosphate buffer, The pH is 6.9‑7.0. It also provides its preparation method: accurately weigh EDTA‑Na in proportion 2 , carboxymethyl chitosan, sodium alginate and lidocaine hydrochloride, EDTA‑Na 2 Heat to dissolve under alkaline conditions, then dissolve carboxymethyl chitosan and sodium alginate, then mix the two, stir evenly, then add lidocaine hydrochloride solution, use HCl to adjust the pH to 6.7‑6.9, stir to dissolve ,Volume. The decontamination agent of the invention has the function of chelating and adsorbing various radionuclides, has no toxic and side effects, and can be used as a low-toxicity and high-efficiency radionuclide pollution decontamination agent.

The object of the present invention is a method for obtaining injectable hydrogels based on hyaluronic acid containing lidocaine hydrochloride and alkaline agents added in powder or solution form, said hydrogels being heat sterilized, having a transparent The hyaluronic acid concentration and flow properties were equivalent to the corresponding hydrogels based on hyaluronic acid without any lidocaine hydrochloride. The present invention also relates to various uses of the aforementioned hydrogels.

The invention relates to the field of Chinese and Western medicine compound preparations, and specifically discloses a compound Chinese and Western medicine mixture for children with stomatitis and a preparation method thereof. Its prescription is composed of the following ingredients: flea 2g-4g, shegan 3g-5g, white fresh skin 3g-5g, angelica dahurica 0.5g-2g, Qingdai 0.5g-2g, root ginseng 0.3g-3g, borax 0.5g g-3g, cinnabar 0.05g-1g, borneol 0.02g-2g, gentamicin 80,000 units-160,000 units, lidocaine hydrochloride 0.05g-0.1g. Its preparation method is: according to the proportion of the above-mentioned Chinese medicine components, select pure and high-quality herbal medicine decoction pieces, remove impurities, first grind the other eight Chinese medicine raw materials except cinnabar into 120-160 mesh fine powder, and then grind the cinnabar to a fineness of 120-160 mesh No friction is the degree, dry it into a block, then mix the ground cinnabar with the previously developed Chinese medicine ingredients evenly, put it in a light-proof sealed container, and add gentamicin according to the proportion in the formula when it is used Sodium glutamate, lidocaine hydrochloride and an appropriate amount of 0.9% physiological saline are mixed uniformly to make an external water agent that can be sprayed. The present invention has high curative effect and short course of treatment, is an external spraying medicament, can be sprayed, is convenient for children to use, and has obvious advantages compared with existing medicines and treatments.