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Medicinal composition containing ceftriaxone sodium and lidocaine hydrochloride injection

A technology for lidocaine hydrochloride and ceftriaxone sodium, which is applied in the field of pharmaceutical preparations, can solve the problems that the use concentration of lidocaine hydrochloride should not be too high, the medicinal solution is wasted, and is unfavorable for clinically standardized medication, and achieves stable and controllable product quality. Effect

Inactive Publication Date: 2007-04-11
GUANGZHOU PUIS PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when used as a local pain reliever, the concentration of lidocaine hydrochloride should not be too high, otherwise it will cause drug malabsorption or other side effects
However, due to the limitation of commonly used clinical specifications, lidocaine hydrochloride injection often needs to be further diluted or only used in a certain volume, which will cause some problems, such as inaccurate quantification of lidocaine hydrochloride, waste of liquid medicine, etc. Convenience, not conducive to clinical standard drug use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] prescription:

[0033] Ceftriaxone Sodium 250g

[0034] Lidocaine Hydrochloride Sterile Powder 10g

[0035] Make 1000 sticks

[0036] Preparation Process

[0037] 1. Take about 14g of the crude lidocaine hydrochloride raw material, dissolve it in 21ml of absolute ethanol, add 0.1% (W / V) activated carbon, stir and decolorize, filter through decarbonization and sterilization, and stir the filtrate at 5-10℃ Add 420ml of ether under (30-35r / min), then let it stand until the crystals are completely precipitated, filter, wash the crystals with ether, filter dry, place in a vacuum oven to dry under reduced pressure and low temperature to obtain sterile lidocaine hydrochloride powder

[0038] 2. Take the above-mentioned prescription amount of ceftriaxone sodium and lidocaine hydrochloride sterile powder into a sterile container, use a powder mixing machine for sterile powder mixing, and dispense into antibiotic glass bottles.

Embodiment 2

[0040] prescription:

[0041] Ceftriaxone Sodium 500g

[0042] Lidocaine Hydrochloride Sterile Powder 20g

[0043] Make 1000 sticks

[0044] Preparation Process

[0045] 1. Take about 27g of the crude lidocaine hydrochloride raw material, dissolve it in 41ml of absolute ethanol, add 0.1% (W / V) activated carbon, stir and decolorize, filter through decarbonization and sterilization, and stir the filtrate at 5-10℃ (30-35r / min), add 820ml of ether, then let it stand until the crystals are completely precipitated, filter, wash the crystals with ether, filter dry, place in a vacuum oven to dry under reduced pressure and low temperature to obtain sterile lidocaine hydrochloride powder.

[0046] 2. Take the above-mentioned prescription amount of ceftriaxone sodium and lidocaine hydrochloride sterile powder into a sterile container, use a powder mixing machine for sterile powder mixing, and dispense into antibiotic glass bottles.

Embodiment 3

[0048] prescription:

[0049] Ceftriaxone Sodium 1000g

[0050] Lidocaine Hydrochloride Sterile Powder 40g

[0051] Make 1000 sticks

[0052] Preparation Process

[0053] 1.1. Take about 50g of the crude lidocaine hydrochloride raw material, dissolve it in 75ml of absolute ethanol, add 0.1% (W / V) activated carbon, stir and decolorize, filter through decarbonization and sterilization, and stir the filtrate at 5-10℃ Add 1500ml of ether under (30-35r / min), then let it stand until the crystals are completely precipitated, filter, wash the crystals with ether, filter dry, and place in a vacuum oven to dry under reduced pressure and low temperature to obtain sterile lidocaine hydrochloride powder.

[0054]2. Take the above-mentioned prescription amount of ceftriaxone sodium and lidocaine hydrochloride sterile powder into a sterile container, use a powder mixing machine for sterile powder mixing, and dispense into antibiotic glass bottles.

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PUM

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Abstract

The invention relates to a medicine composition for injection containing ceftriaxone sodium and Lidocaine Hydrochloride, and characterized by said composition contains 50mg-5000mg ceftriaxone sodium, 1mg-100mg Lidocaine Hydrochloride. The composition in said invention is prepared by split charging of germ-free ceftriaxone sodium and Lidocaine Hydrochloride in accordance with specifications.

Description

Technical field [0001] The invention relates to a sterile subpackaged pharmaceutical composition for injection containing ceftriaxone sodium and lidocaine hydrochloride, and belongs to the technical field of pharmaceutical preparations. Background technique [0002] Ceftriaxone sodium is the disodium salt of ceftriaxone. It is a long-acting, broad-spectrum antibiotic. It belongs to the third-generation cephalosporin. It has a strong bactericidal effect on gram-negative and gram-positive bacteria. It has a serum Long half-life and other characteristics. It has bactericidal activity mainly by inhibiting the synthesis of cell wall, and has high stability to β-lactamase (penicillinase and cephalosporinase). [0003] Ceftriaxone usually has a bactericidal effect on the following pathogenic bacteria: [0004] It has strong activity against Enterobacteriaceae bacteria. MIC for Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter flurodonii, Indole-positive Proteu...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K31/16A61K9/19A61K47/26A61P31/04
Inventor 贝庆生
Owner GUANGZHOU PUIS PHARMA FACTORY
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