2 results about "Sodium ceftriaxone" patented technology

The application relates to the technical field of special equipment manufacturing for pharmacy, in particular to an integrated multifunctional tank for ceftriaxone sodium production, which integrates multiple functions such as stirring, filtering, vacuum treatment, online reaction detection and flushing in one body. The tank body is composed of a top head, an inner cylinder and a bottom head, is equipped with a stirring assembly driven by a speed reducer motor, a feeding pipe opening assembly, a filtering assembly between the inner cylinder and the bottom head, an auxiliary filtering system with a sintered filter element group, a flushing assembly connected with the stirring assembly and a reaction detection assembly for real-time acquisition of reaction parameters. The application solves the problems of traditional ceftriaxone sodium production equipment, such as function dispersion, complicated operation steps and low production efficiency, simplifies the production process through integrated design, improves the controllability and stability of the production process and effectively guarantees the product quality.

The application belongs to the technical field of medicine, and particularly relates to a ceftriaxone sodium powder injection and a preparation method thereof. The water-soluble vitamin E and L-cysteine are used to synergistically play the roles of antioxidation and anti-aggregation, and effectively inhibit the polymer generation and the aggregation phenomenon in the crystallization process. The mesoporous silica modified by chitosan is used as a drug carrier, the ordered drug is promoted to enter the mesoporous channel through the positive charge mediation, the efficient loading of the drug is realized, and the biocompatibility is improved. The supercritical anti-solvent crystallization technology is used, the drug is in-situ crystallized in the mesoporous channel to form a highly dispersed state, the specific surface area of the drug is significantly increased, and the ultrafast dissolution is realized. The ceftriaxone sodium powder injection prepared by the application has the excellent characteristics of fast dissolution speed, uniform particle size, no aggregation, good stability, high safety, and high drug loading efficiency.