Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Preparation method of liposome of medicine composition of ceftriaxone sodium and sulbactam sodium

A technology of ceftriaxone sodium and sulbactam sodium, which can be used in liposome delivery, pharmaceutical formulations, active ingredients of heterocyclic compounds, etc., and can solve problems such as poor absorption

Active Publication Date: 2013-03-20
JIANGSU SKYRUN PHARMA CO LTD
View PDF2 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poor absorption of sulbactam sodium after oral administration

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of liposome of medicine composition of ceftriaxone sodium and sulbactam sodium
  • Preparation method of liposome of medicine composition of ceftriaxone sodium and sulbactam sodium
  • Preparation method of liposome of medicine composition of ceftriaxone sodium and sulbactam sodium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] Set forth the present invention with example below:

[0021] Case number one:

[0022] Ceftriaxone Sodium 100g Sulbactam Sodium 50g Soy Lecithin 100 cholesterol 33g Sodium dihydrogen phosphate 1.6g Disodium phosphate 0.3g production 100 bottles

[0023] Preparation process: Take the prescribed amount of soybean lecithin and cholesterol and dissolve them completely in 230ml of absolute ethanol. or mixed.) Remove absolute ethanol on a rotary evaporator to obtain a phospholipid film.

[0024] Weigh 0.3 g of disodium hydrogen phosphate and 1.6 g of sodium dihydrogen phosphate and add it to 800 ml of water to dissolve completely, prepare a phosphate buffer solution (PBS) with a pH of about 5.8, add it to the phospholipid membrane for hydration, and use a high-pressure homogenizer to prepare a blank lipid body.

[0025] Weigh ceftriaxone sodium and dissolve it in 800ml of water, filter it at 0.45um after dissolving complet...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method of liposome of a medicine composition of ceftriaxone sodium and sulbactam sodium. According to the method, the liposome is prepared in a combining form of medicines, and the specification proportion of the ceftriaxone sodium to the sulbactam sodium is equal to (1-4):1. The preparation method comprises the following main steps of: preparing blank liposome from phospholipid and cholesterol, preparing the liposome from the ceftriaxone sodium and the sulbactam sodium which are respectively subjected to passive loading, and performing freeze drying on the prepared liposome to obtain a finished product; or dissolving the ceftriaxone sodium and the sulbactam sodium in phosphate buffer with the pH ranging from 6.0 to 6.5, and adding phospholipid cholesterol and a freeze-dried support agent to the solution in an active loading manner to prepare a freeze-drying preparation of the liposome.

Description

technical field [0001] The invention relates to a preparation method of a liposome related to ceftriaxone sodium sulbactam sodium pharmaceutical composition, and belongs to the field of pharmaceutical preparations. Background technique [0002] Ceftriaxone sodium is a third-generation cephalosporin antibiotic with strong activity against Enterobacteriaceae. The MIC90 for Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter freundii, indole-positive Proteus, Pruvidenella and Serratia is between 0.12 and 0.25mg / Between L. Enterobacter cloacae, Acinetobacter and Pseudomonas aeruginosa were less sensitive to the drug. It has strong antibacterial effect on Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis, and also has good effect on hemolytic streptococcus and pneumococcus. The MIC for Staphylococcus aureus is 2-4mg / L. Methicillin-resistant staphylococci and enterococci were resistant to this drug. Most Bacteroides fragilis ar...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/546A61K31/43A61K9/127A61P31/04
Inventor 燕立波王丽赵晖程思
Owner JIANGSU SKYRUN PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com