Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of ceftriaxone sodium crystal with good stability and high operability

A ceftriaxone sodium, operable technology, applied in organic chemistry methods, organic chemistry and other directions, can solve the problems of poor crystal form and poor stability of ceftriaxone sodium, and achieve good stability, uniform crystal particles, Easy to operate effect

Pending Publication Date: 2020-11-10
REYOUNG PHARMA
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It adopts water-ethanol as a solvent, adopts isopropanol-ethanol as a dissolution agent, and adds a certain amount of antioxidant, so that the degradation degree of the product in the crystallization process is reduced and the oxidation resistance is greatly improved; but it directly uses ceftriaxone sodium As a crystal seed, the crystal form of ceftriaxone sodium obtained is relatively poor, and the stability is not good

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of ceftriaxone sodium crystal with good stability and high operability
  • Preparation method of ceftriaxone sodium crystal with good stability and high operability
  • Preparation method of ceftriaxone sodium crystal with good stability and high operability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Weigh 8 g of ethanol, 10 g of water, and 5 g of ceftriaxone sodium, stir and dissolve at a stirring temperature of 15° C. and a stirring rate of 25 Hz as seed crystals;

[0031] (2) Weighing 500 g of the crude product of ceftriaxone sodium and adding it to 1250 g of purified water, stirring and dissolving at 15° C., adding 100 g of activated carbon after dissolving to decolorize and filter with stirring to obtain the filtrate for subsequent use;

[0032] (3) Slowly add 1500g of acetone dropwise to the filtrate obtained in step (2), and no solid precipitates at this time, then add the seed crystal prepared in step (1), maintain 15°C, grow the crystal for 30min, then continue to add 7500g of acetone, and stir Crystallization solution was obtained after 4h;

[0033] (4) The crystallization solution obtained in step (3) is lowered in temperature, filtered, washed, and dried in sequence to obtain ceftriaxone sodium crystals.

Embodiment 2

[0035] (1) Weigh 8 g of acetone, 10 g of water, and 5 g of ceftriaxone sodium, stir and dissolve at a stirring temperature of 15° C. and a stirring rate of 25 Hz as seed crystals;

[0036] (2) Weighing 500 g of the crude product of ceftriaxone sodium and adding it to 1250 g of purified water, stirring and dissolving at 15° C., adding 100 g of activated carbon after dissolving to decolorize and filter with stirring to obtain the filtrate for subsequent use;

[0037] (3) Slowly add 500g of acetone dropwise to the filtrate obtained in step (2), and no solid is precipitated at this time, then add the seed crystal prepared in step (1), maintain 15°C, grow the crystal for 30min, then continue to add 7500g of acetone, and stir Crystallization solution was obtained after 4h;

[0038] (4) The crystallization solution obtained in step (3) is lowered in temperature, filtered, washed, and dried in sequence to obtain ceftriaxone sodium crystals.

Embodiment 3

[0040] (1) Weigh 5.5 g of isopropanol, 10 g of water, and 5 g of ceftriaxone sodium, stir and dissolve at a stirring temperature of 15° C. and a stirring rate of 25 Hz as seed crystals;

[0041] (2) Weighing 500 g of ceftriaxone sodium crude product and adding it to 1250 g of purified water, stirring and dissolving at 15° C., adding 10 g and 100 g of activated carbon after dissolving to decolorize and filter with stirring to obtain the filtrate for subsequent use;

[0042] (3) Slowly add 1500g of acetone dropwise to the filtrate obtained in step (2), and no solid is precipitated at this time, then add the seed crystal prepared in step (1), maintain 15°C, grow the crystal for 30min, then continue to add 7500g of acetone, and stir Crystallization solution was obtained after 4h;

[0043] (4) The crystallization solution obtained in step (3) is lowered in temperature, filtered, washed, and dried in sequence to obtain ceftriaxone sodium crystals.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation method of a ceftriaxone sodium crystal with good stability and high operability. The preparation method of the ceftriaxone sodium crystal with good stability and high operability comprises the following steps: firstly, stirring and dissolving an organic solvent, water and ceftriaxone sodiumin a mass ratio of 1-10: 1-5: 1 at the temperature of 5-25DEG C and the stirring rate of 10-45Hz to obtain a seed crystal; dissolving the ceftriaxone sodium crude product into purified water, adding activated carbon after dissolving, and performing stirring, and filtering to obtain filtrate for later use; slowly dropwise adding acetone into the filtrate, adding crystal growth crystals, then continuously adding acetone to obtain a crystallization solution, and sequentially performing cooling, filtering, washing and drying to obtain ceftriaxone sodium crystals. The preparation method is simple in reaction condition, easy to operate, easy to control and good in repeatability, and the obtained ceftriaxone sodium crystal is uniform in particle, good in crystal form, good in stability and suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a method for preparing ceftriaxone sodium crystals with good stability and high operability. Background technique [0002] Ceftriaxone sodium is a spectrum antibiotic, which belongs to the third generation cephalosporins. It exerts antibacterial effect by inhibiting the synthesis of bacterial cell wall, and has a strong bactericidal effect on most Gram-negative bacteria and Gram-positive bacteria. . It has the characteristics of strong antibacterial effect, long half-life, etc., and has strong stability to β-lactamase. [0003] Ceftriaxone sodium as a sterile injection, its efficacy and stability is the top priority. Among the factors affecting stability, the crystal form is particularly important. The corresponding properties of different crystal forms of the same drug may be very different, and may even have no effect at all. Therefore, in the prior art,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D501/36C07D501/12
CPCC07D501/36C07D501/12C07B2200/13
Inventor 苗得足胡清文赵磊刘善庐王向华
Owner REYOUNG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com