Ceftriaxone sodium composition freeze-dried powder for injection

A technology of ceftriaxone sodium and freeze-dried powder injection, which is applied in the field of medicine and medicine manufacturing, and can solve problems such as superinfection, unreasonable drug combination, toxic and side effects, etc.

Inactive Publication Date: 2014-01-29
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When clinicians choose this kind of antibacterial drugs, in order to enhance the efficacy, reduce adverse reactions or delay the emergence of drug resistance, they often use combination drugs, but there are also clinically unreasonable combination drugs that weaken the antibacterial effect and even cause serious toxicity Side effects, superinfection, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, preparation of ceftriaxone sodium composition freeze-dried powder for injection, in 1000 pieces.

[0029] 1. Prescription:

[0030] Ceftriaxone Sodium 1000g

[0031] Chitosan Nanoparticles 800g

[0032] Water for injection 2000ml

[0033] 2. Preparation process:

[0034] The chitosan nanoparticle that weighs 800g is slowly added in the water for injection of 2000ml, stirs while adding, until dissolving.

[0035] Add 1000 g of ceftriaxone sodium and stir to dissolve until clear.

[0036] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to the calculation of ceftriaxone sodium 1.0g per bottle.

[0037] Fill according to the test requirements, put it into a freeze dryer after half-tamping, cool ...

Embodiment 2

[0038] Embodiment 2, preparation of lyophilized powder injection of ceftriaxone sodium composition for injection, in 1000 pieces.

[0039] 1. Prescription:

[0040] Ceftriaxone Sodium 1000g

[0041] Chitosan Nanoparticles 865g

[0042] Water for injection 2000ml

[0043] 2. Preparation process:

[0044] The chitosan nanoparticle that weighs 865g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.

[0045] Add 1000 g of ceftriaxone sodium and stir to dissolve until clear.

[0046] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to the calculation of ceftriaxone sodium 1.0g per bottle.

[0047] Fill according to the test requirements, put it into a freeze dryer after half-tamping, c...

Embodiment 3

[0048] Embodiment 3, preparation of ceftriaxone sodium composition freeze-dried powder for injection, in 1000 pieces.

[0049] 1. Prescription:

[0050] Ceftriaxone Sodium 1000g

[0051] Chitosan Nanoparticles 757g

[0052] Water for injection 2000ml

[0053] 2. Preparation process:

[0054] The chitosan nanoparticle that takes by weighing 757g is slowly added in the water for injection of 2000ml, stirs while adding, until dissolving.

[0055] Add 1000 g of ceftriaxone sodium and stir to dissolve until clear.

[0056] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to the calculation of ceftriaxone sodium 1.0g per bottle.

[0057] Fill according to the test requirements, put it into a freeze dryer after half-tam...

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Abstract

The invention provides a ceftriaxone sodium composition freeze-dried powder for injection, and belongs to the field of medicine and medicine preparation technology. The ceftriaxone sodium composition freeze-dried powder comprises following raw material ingredients, by weight, 7.26 to 9.17 parts of ceftriaxone sodium, 5.78 to 7.67 parts of chitosan nanoparticle, and 81.38 to 87.10 parts of injection water. Advantages of the ceftriaxone sodium composition freeze-dried powder are that: 1) activity of the ceftriaxone sodium composition in treatment of gonorrhoea is increased significantly, so that combination medication of other antibiotics with ceftriaxone sodium with unknown action mechanisms is avoided in clinic; 2) antibacterial spectrum is widened, and drug tolerance is reduced greatly; 3) improvement of activity is capable of shortening medication cycle of patients, and reducing occurrence likelihood of adverse reaction caused by accumulation of ceftriaxone sodium; and 4) the chitosan nanoparticle can be used as a freeze-dried skeleton agent of the freeze-dried powder injection instead of mannitol, so that active effects of mannitol on human bodies are avoided.

Description

Technical field: [0001] The invention relates to the technical field of medicine and medicine manufacture, in particular to a ceftriaxone sodium composition freeze-dried powder for injection. Background technique: [0002] Ceftriaxone sodium is a semi-synthetic third-generation cephalosporin, which has strong antibacterial activity against most Gram-positive and negative bacteria. , Enterobacter aerogenes, Proteus, Diplococcus and Staphylococcus aureus. This medicinal product is stable to beta-lactamases. [0003] Clinically, it is mainly used for meningitis, pneumonia, skin and soft tissue infection, peritonitis, urinary system infection, gonorrhea, liver and gallbladder infection, surgical trauma, sepsis and genital infection, which are infected by sensitive bacteria. It has been used as the first-line drug for the treatment of gonorrhea. When clinicians choose this kind of antibacterial drugs, in order to enhance the efficacy, reduce adverse reactions or delay the emerg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/546A61K47/36A61P31/04A61K31/722
Inventor 汪六一汪金灿张庆庆
Owner HAINAN WEI KANG PHARMA QIANSHAN
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