The invention relates to a composition for treating acne as well as a preparation method and application thereof. The composition is prepared from the following raw materials in parts by weight: 400 to 1,200 parts of Vaseline, 8 to 80 parts of benzoic acid, 4 to 40 parts of boric acid, 6 to 60 parts of salicylic acid, 40 to 120 parts of ichthammol, 1 to 10 parts of vitamin E, 2 to 15 parts of borneol, 10 to 40 parts of radix sophorae flavescentis, 5 to 25 parts of radix scutellariae, 5 to 25 parts of cortex phellodendri chinensis, 5 to 25 parts of rhizoma coptidis, 10 to 40 parts of radix et rhizoma rhei and 20 to 120 parts of plant essential oil. The composition has the advantages of being short in medication cycle, obvious in curative effects and convenient to use and not influencing daily makeup in a use process. The composition for treating the acne, which is provided by the invention, can be used for quickly permeating a skin, is used for promoting the skin to absorb a medicine, changing a microenvironment, clearing away heat and toxic materials, removing the symptoms of redness, swelling and pain, balancing grease secretion, enabling skin to be fresh, cool, bright and clean, and quickening the skin to heal, is insecticidal and anti-inflammatory, and is applicable to the treatment of the acne which is to various extents and the prevention of the formation of the acne and the mark of the acne.