9 results about "Targeted microbubbles" patented technology

The present invention relates to methods of producing microbubble drug conjugates, viral gene therapy microbubble drug conjugates, and disease-targeting microbubbles, for clinical and preclinical ultrasound-mediated therapeutic and diagnostic applications. It includes methods to produce viral vector gene therapy microbubble drug conjugates with antibody linkers conjugated to lipid shelled microbubbles that both bind to and neutralize viral vectors such that the viral gene therapy can transduce and effect permanent genetic changes only after ultrasound is used to disassociate the viral gene therapy from microbubbles at diseased regions of the body.

Selective displacement of two or more distinct monodisperse targeted microbubble (tMB) populations presenting unique surface ligands by matching the incoming ultrasound frequency to the size-dependent resonance frequency of each tMB population thereby selecting their respective translations towards a target cell or tissue.

The invention discloses an underwater propeller control method and system based on cavitation corrosion analysis. The method and system are used for reducing the cavitation corrosion condition of an underwater propeller in a real scene. The method comprises the following steps: acquiring an acquired image of a shaftless propulsion system in an underwater propeller, the underwater propeller further comprising a micro-bubble injection system, and uniformly distributed micro-bubble outlets are formed in the micro-bubble injection system; determining an effective area of the acquired image, performing corrosion detection on the effective area, and determining a corrosion area and a corrosion type label; determining a target microbubble outlet of which the microbubble acting point location is located in the corrosion area; when the underwater propeller runs, obtaining current water body information of the underwater propeller and running environment information of a propelling system in real time; the cavitation rotating speed threshold value of the underwater propeller is updated according to the propelling system operation environment information and the corrosion type label; when the real-time rotating speed exceeds the updated cavitation rotating speed threshold value, microbubble output parameters of a target microbubble outlet are adjusted according to the water body information and the corrosion type label.

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

The present application discloses an underwater propeller control method and system based on cavitation corrosion analysis, which is used to reduce the cavitation corrosion of underwater propellers in real scenarios. The method includes obtaining an image of a shaftless propulsion system in the underwater propeller, wherein the underwater propeller also includes a microbubble injection system, and the microbubble injection system is provided with uniformly distributed microbubble outlets; determining the effective area of the acquired image, and performing corrosion detection on the effective area to determine the corrosion area and corrosion type label; determining the target microbubble outlet whose microbubble action point is located in the corrosion area; when the underwater propeller is running, obtaining the current water body information and propulsion system operating environment information of the underwater propeller in real time; updating the cavitation speed threshold of the underwater propeller according to the propulsion system operating environment information and the corrosion type label; and when the real-time speed exceeds the updated cavitation speed threshold, adjusting the microbubble output parameters of the target microbubble outlet according to the water body information and the corrosion type label.

The invention discloses a targeting microbubble for targeting microvascular endothelium as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The targeted microvesicle of the targeted microvascular endothelium provided by the invention comprises a biotinylated liposome microvesicle combined with streptavidin and a biotinylated carbonic anhydrase 4 antibody, the biotinylated liposome microbubble combined with streptavidin takes lipid as a shell membrane material, fluorinated inert gas is wrapped in the shell membrane material, and the surface of the shell membrane material is combined with streptavidin; and the shell membrane material is prepared from DSPC (Distearoyl Pyrrolidone), DSPE-PEG (Polyethylene Glycol) 2000 and DSPE-PEG 2000-biotin. The targeting microbubble has good targeting property, biocompatibility and safety, and can intuitively reflect the density difference of microvessels, thereby providing an intuitive and reliable imaging basis for early diagnosis and disease assessment of coronary artery microvascular diseases.

Described herein are pharmaceutical compositions containing genes encoding a positive regulatory domain zinc finger protein 16, a peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein, and a bone morphogenetic protein 7. Also disclosed are methods of treating or managing obesity and diabetes by delivering these pharmaceutical compositions using ultrasound-targeted microbubble destruction.

The invention discloses an ultrasonic contrast agent microbubble detection and analysis system based on intelligent perception, particularly relates to the field of ultrasonic imaging, is used for solving the problem of accurate detection and analysis of multi-target labeled microbubbles in a complex blood flow environment, and is characterized in that an ultrasonic probe is triggered by broadband pulse to obtain original data, and information of an included angle between a scanning plane and a blood flow is combined; projection deviation is corrected through a micro-angle resampling technology, an accurate and consistent micro-bubble time-frequency three-dimensional image tensor is generated, and signal quality is ensured. Then, features are extracted by means of sparse phase decoding and complex independent component decomposition, signal separation and classification are optimized in combination with a pre-trained microbubble fingerprint model and an attention network, and the problems of aliasing and distortion are effectively solved; meanwhile, dynamic tracking and density analysis of the microbubbles are realized through frequency attenuation plane projection and particle filtering, and real-time motion and distribution information is provided; and finally, integrating the density curve and the frequency attenuation slope to generate a targeted microbubble concentration time sequence table, and transmitting the targeted microbubble concentration time sequence table to a clinical end through a data interface.