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Compositions and methods of controlling expression of thermogenin (UCP-1) in skeletal muscles,Ultrasound-targeted microbubbles for treating lung cancer and preparation method and application thereof

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Compositions and methods of controlling expression of thermogenin (UCP-1) in skeletal muscles

ActiveUS12616735B2Peptide/protein ingredientsGenetic material ingredientsPharmaceutical SubstancesActivating receptors

Described herein are pharmaceutical compositions containing genes encoding a positive regulatory domain zinc finger protein 16, a peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein, and a bone morphogenetic protein 7. Also disclosed are methods of treating or managing obesity and diabetes by delivering these pharmaceutical compositions using ultrasound-targeted microbubble destruction.

Compositions and methods of controlling expression of thermogenin (UCP-1) in skeletal muscles

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Owner:THERMOGEN BIOTHERAPEUTICS LLC

Ultrasound-targeted microbubbles for treating lung cancer and preparation method and application thereof

PendingCN122399054AOncologyLung cancer

本发明涉及一种治疗肺癌的超声靶向微泡及其制备方法和应用，所述超声靶向微泡为脂质微泡，其外表面附有链霉亲和素，所述链霉亲和素的密度为每个微泡包含1.0×105‑1.5×105个分子；并且所述超声靶向微泡的外表面负载有生物素化贝伐珠单抗，所述生物素化贝伐珠单抗的密度为每个微泡包含0.8×105‑1.2×105个分子；所述链霉亲和素与所述负载有生物素化贝伐珠单抗相连接；所述超声靶向微泡的内部包含全氟化碳气体，所述全氟化碳气体的密度为每个微泡含1.7×10‑16‑2.0×10‑16mol或体积为4.0‑4.5μm3。本发明的负载贝伐珠单抗的超声靶向微泡具有能够显著抑制肺癌移植瘤的生长和血管生成等优点。

Ultrasound-targeted microbubbles for treating lung cancer and preparation method and application thereof

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Owner:NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A