NO-loaded targeted microbubble, preparation method and application thereof

A technology of microbubbles and streptavidin, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of severe infection, toxicity, and high cost, and achieve safety The effect of high and good clinical application prospects
CN110974844AActive Publication Date: 2020-04-10THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
Publication Date
2020-04-10

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Abstract

The invention discloses a targeted microbubble loaded with NO and a preparation method thereof. The microbubble is a hollow liposome. The surface of the liposome is bonded with streptavidin, which iscoupled with a biotin modified C4d / C3d antibody. The liposome is filled with a mixed gas of NO / CO and polymer inert gas. According to the invention, the novel microbubble NO-MBC4d is successfully prepared, and the microbubble is utilized to successfully realize targeted and accurate treatment of graft AMR. The treatment process has high safety, and the microbubble has a good clinical application prospect.
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Description

technical field

[0001] The invention relates to the technical field of heart transplantation rejection treatment, in particular to a C4d targeting microbubble loaded with NO (nitric oxide) and its preparation method and application. Background technique

[0002] Heart transplantation is the best treatment for end-stage heart disease, however, the incidence of antibody-mediated rejection (AMR) in heart transplantation remains high and is considered an important factor in graft loss 1 .

[0003] AMR is caused by anti-donor specific antibody (DSA). After DSA binds to the antibody on the surface of the graft vascular endothelial cells, it activates the complement system through the classical pathway and damages the graft. At the same time, chemokines such as C3a and C5a can recruit immune cells such as macrophages, T cells, and B cells to migrate to the graft, thereby damaging the graft. 2 . C4d is a cleavage fragment activated by complement, which can be covalently bound to ...

Claims

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