A kind of NO-loaded targeting microbubble and preparation method and application thereof

A technology of targeting microbubbles and microbubbles, applied in the field of NO-loaded C4d targeting microbubbles and its preparation, can solve the problems of severe infection, toxicity, and high cost, and achieve high safety and good clinical application prospects
CN110974844BActive Publication Date: 2022-03-04THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
Publication Date
2022-03-04

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Abstract

The invention discloses a targeting microbubble loaded with NO and a preparation method thereof. The microbubble is a hollow liposome, streptavidin is combined on the surface of the liposome, and C4d modified by streptavidin and biotin / C3d antibody coupling, the liposome is filled with a mixed gas of NO / CO and polymer inert gas. The present invention successfully prepared NO‑MB C4d This new type of microbubbles, and using the microbubbles, has successfully realized the targeted and precise treatment of AMR in grafts. The treatment process is safe and has a good clinical application prospect.
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Description

technical field

[0001] The invention relates to the technical field of heart transplantation rejection treatment, in particular to a C4d targeting microbubble loaded with NO (nitric oxide) and its preparation method and application. Background technique

[0002] Heart transplantation is the best treatment for end-stage heart disease, however, the incidence of antibody-mediated rejection (AMR) in heart transplantation remains high and is considered an important factor in graft loss 1 .

[0003] AMR is caused by anti-donor specific antibody (DSA). After DSA binds to the antibody on the surface of the graft vascular endothelial cells, it activates the complement system through the classical pathway and damages the graft. At the same time, chemokines such as C3a and C5a can recruit immune cells such as macrophages, T cells, and B cells to migrate to the graft, thereby damaging the graft. 2 . C4d is a cleavage fragment activated by complement, which can be covalently bound to ...

Claims

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