141results about How to "Improve tumor treatment effect" patented technology

The invention provides a composite gold nanorod carrier having photo-thermal/photodynamic therapy treatment performance and a preparation method thereof. The composite gold nanorod carrier uses a gold nanorod as a core and uses silicon dioxide as a shell layer, a near infrared fluorescent dye for photodynamic therapy is modified on the outer surface of the shell layer. The preparation method comprises the steps that a chloroauric acid solution and a cetyl trimethyl ammonium bromide solution are mixed, a sodium borohydride ice water mixed solution is added to obtain a nano gold seed solution A; a silver nitrate solution and a chloroauric acid solution are added to a binary surface active agent solution, a hydrochloric acid is added after reaction to obtain a solution B, then ascorbic acid and the solution A are added, and a gold nanorod is obtained after reaction; a tetraethoxysilane methanol solution and an aminopropyl trimethoxy silane methanol solution are added to a gold nanorod solution to obtain composite nanoparticles; 1-(3-dimethyl amino propyl)-3-ethyl carbodiimide hydrochloride is added to the near infrared fluorescent dye, then N-hydroxyl succinimide is added to obtain a solution C; the composite nanoparticle solution is mixed with the solution C to obtain a product.

The invention discloses a mesoporous polydopamine loaded manganese carbonyl multifunctional nano diagnosis and treatment agent and a preparation method and an application thereof. The multifunctionalnano diagnosis and treatment agent is a water-soluble mesoporous polydopamine carrier-coated hydrophobic manganese carbonyl drug, wherein the mass ratio of mesoporous polydopamine to manganese carbonyl is 1-8:1. The multifunctional nano diagnosis and treatment agent realizes gas and photo-thermal collaborative treatment under MRI and photoacoustic imaging guiding, is hopeful for increasing tumourtreatment effect, has good biocompatibility, and has clinical application potential.

The invention relates to a hypoxia response polymer nanoparticle and application thereof. The method comprises the following steps: firstly crosslinking 4,4-diaminoazobenzene and terephthalaldehyde taken as monomers, so as to form a conjugated polymer link, loading a photosensitizer and chemotherapy drugs through noncovalent interaction, and then forming the hypoxia response polymer nanoparticle through a nanoprecipitation method. The hypoxia response polymer nanoparticle can successfully carry the photosensitizer and the chemotherapy drugs to tumor cells, and produce active oxygen during illumination, so as to realize tumor killing. Azo bonds contained in the nanoparticle can be degraded under the action of reductase in cells, and chemotherapy drug release is realized. In addition, cell hypoxia caused during a photodynamic therapy process can further improve drug release, and the hypoxia response polymer nanoparticle can properly realize excellent tumor therapy effect through combination therapy effect of photodynamic therapy and chemical therapy.

The invention discloses an acid-responsive nanometer micelle for drug loading, a preparation method and an application thereof. The nano-micelles were self-assembled from hydrophilic segment polyethylene glycol (PEG) and hydrophobic segment pH-sensitive polyaspartyl diisopropylethylenediamine/di-n-butylethylenediamine (PAsp (DIP/DBA)). The nano-micelles can prolong the drug circulation time, aggregate in the tumor site, increase the local drug concentration, and respond to the micro-acid environment of the tumor tissue. As a drug carrier of stimulation response, the nano-micelles can rapidly release the loaded chemotherapeutic drug adriamycin in the tumor site, and play a significant anti-tumor effect. At the same time, the nano-micelles loaded with magnetic resonance contrast agent superparamagnetic iron oxide can be used for tumor magnetic resonance imaging and monitoring drug uptake and aggregation. This method utilizes nano-drug aggregation at tumor site and acid responsiveness ofcarrier to realize rapid drug release to improve tumor therapeutic effect, and endows nano-micellar MRI visualization function, which provides a promising innovative strategy for cancer diagnosis andtreatment, and has broad application prospects.

The invention discloses a porphyrin-based metal organic framework nano-carrier with a sonodynamic combined starvation therapy anti-tumor function and a preparation method of the porphyrin-based metal organic framework nano-carrier. The preparation method comprises the following steps: dissolving a porphyrin-based ligand and metal salt in a solvent, and heating to obtain porphyrin-based metal organic framework particles; and dispersing the porphyrin-based metal organic framework particles into water, adding high-valence metal acid or high-valence metal salt and a reducing agent, and mixing with a cell membrane and glucose oxidase to obtain the cell membrane modified porphyrin-based metal organic framework nano-carrier loaded with the metal nanoparticles and the glucose oxidase. The nano-carrier can enhance the accumulation at the tumor site and improve the tumor targeted hunger treatment effect; and meanwhile, tumor hypoxia is relieved, sonodynamic reaction substrates are increased, and the sonodynamic effect is improved. The preparation process is simple and controllable, the material source is wide, and scale amplification can be realized; and in vivo, good stability and tumor sonodynamic and hunger treatment combined treatment effect are achieved, and good application prospects are achieved in the field of tumor treatment.

The invention relates to a polypeptide and chemotherapy drug combined drug-loaded micelle and a preparation method and an application thereof. Polypeptide with a tumor targeting therapeutical effect and a chemotherapy drug are combined to prepare the tumor-targeting polypeptide-PEGylated phospholipid complex-chemotherapy drug drug-loaded micelle; the polypeptide with the tumor targeting therapeutical effect is specifically combined with a chemotactic factor receptor CXCR4, the CXCR4 polypeptide antagonist is used for increasing a targeting penetration ability of the drug to tumor tissues, the PEGylated phospholipid micelle is used for increasing the drug biological stability and the drug loading amount, and compared with a single chemotherapy drug doxorubicin, the combined drug-loaded micelle shows a stronger characteristic of inhibiting tumor cell vitality. The polypeptide and chemotherapy drug combined drug-loaded micelle provides a feasible method and technique for improving the tumor therapeutic effect.

The invention discloses a synergistically reinforced anti-tumor near-infrared photoresponsive NaYF4: Yb, Er-NH2/RBS/GO/BNN6 nanocomposites, NaYF4: Yb, Er-NH2 layer, NO donor RBS layer, GO layer, NO donor BNN6 layer. The NaYF4: Yb, Er-NH2/RBS/GO/BNN6 nanocomposites have good thermal stability and high near-infrared response. NO emission can be triggered and controlled effectively by the switching of near infrared laser, the adjustment of irradiation time and power density. NaYF4: Yb, Er and GO, NO donors RBS and BNN6 can play a synergistic role, greatly enhance the response to near-infrared light, can significantly improve the therapeutic effect of tumor, showing a synergistic enhancement of the anti-tumor effect.

The invention discloses a penetration-enhanced gold nanocluster drug-loaded targeting preparation and a preparation method and application thereof. The targeting preparation comprises gold nanoclusters, a cross-linking agent and a tumor treatment drug, wherein the gold nanoclusters are obtained by assembling gold nanospheres with the cross-linking agent, and the surface of the gold nanoclusters ismodified with the targeting tumor treatment drug of human epidermal growth factor receptor-2. The preparation can be used as an antitumor drug carrier, specifically targets to a tumor, enables the drug to be efficiently released at a tumor site through tumor microenvironment reduction and NIR irradiation, and improves the treatment effect in combination with thermal therapy and action. By the preparation, the advantages of gold in imaging aspects such as CT imaging and photoacoustic imaging (PA) can also be combined for medical diagnosis, and a purpose of multi-mode accurate tumor diagnosis and treatment is achieved.

The invention discloses an acid-sensitive paclitaxel prodrug and a preparing method and an application thereof. The acid-sensitive paclitaxel prodrug has a structure which is shown in the first formula. According to the acid-sensitive paclitaxel prodrug, a polymer precursor is amphipathy two-inlayed-section copolymer of vinyl ether functionlization, and drug molecules are covalently linked to the amphipathy two-inlayed-section copolymer through acetal bonds. The paclitaxel prodrug can be subjected to self-assembly in an aqueous solution, so that prodrug nano-micelle is formed, wherein a polyethylene glycol hydrophilic segment is used as the outer surface, a lateral group is used for polycaprolactone functionlization, and antineoplastic drug paclitaxel which is linked to polymer main chains through the acetal bonds is used as a hydrophobic core. The drug loading capacity of the micelle is higher, and leakage and burst release of the drug can be avoided in the body circulation process. The polymer prodrug has the pH-sensitive acetal bonds, the drug cannot be released under the weak alkaline environment in normal cells, the drug is slowly released under the acid environment in tumour cells, the tumour cells can be killed in a specificity mode, and accordingly the toxic and side effects of the drug are lowered.

The invention discloses a tumor drug-resistant target site and application of the tumor drug-resistant target site. The invention discloses influence of NAC1 (Nucleus Accumbens-1) on tumor medicine treatment, and thus provides a purpose of an NAC1 inhibitor in medicine for reducing or eliminating tumor chemotherapy drug resistance and application of the NAC1 inhibitor as a tumor drug-resistant mark and a drug-resistant tumor prediction and diagnosis and drug-resistant tumor medicine design and screening target. The invention provides a novel mechanism for overcoming tumor drug resistance and improving the curative effect, and provides a novel target for resisting tumor drug resistance.

The invention discloses a nano diagnosis and treatment agent as well as a preparation method and an application thereof. The nano diagnosis and treatment agent is formed by self-assembling organic ligand molecules, Fe <2+> and amphiphilic molecules, wherein a structural formula of the organic ligand molecule is shown in the specification,-R is-CH3 or-CH2CH3, the novel organic ligand molecule designed by the invention can keep the stable valence state of Fe <2+>, Fe <2+> is delivered to a tumor site through a nano self-assembly technology, and a chemical kinetic treatment effect is generated. In addition, the organic ligand molecules also have near-infrared photothermal conversion capability, so that the photothermal therapy is realized, and meanwhile, the chemodynamic therapy effect is improved. The novel drug delivery mode provides a new strategy for tumor synergistic treatment.

The invention relates to an amorphous calcium carbonate composite nano-medicine with an effect of inducing ferroptosis of tumor cells and a preparation method of the amorphous calcium carbonate composite nano-medicine, and belongs to the technical field of medicines. After the composite nano-medicine enters the tumor cells, the degradation of nanoparticles is promoted by means of the acidic environment of lysosomes, meanwhile, the lysosomes are subjected to permeabilization to release doxorubicin and ferrous ions through the protonation of dendrimers, wherein ferrous ions can promote the conversion of polyunsaturated fatty acids of cell membranes to lipid peroxides and induce ferroptosis of the tumor cells, and DOX can promote oxidative stress to increase the content of hydrogen peroxide in the cells while inducing apoptosis, so that iron-dependent ferroptosis caused by lipid peroxidation induced by the ferrous irons is further enhanced. The composite nanoparticles can not only increase the therapeutic effect of tumors, but also reduce the side effects caused by chemotherapy.

The invention relates to preparation of thermosensitive liposome co-loaded with hollow gold nanoparticles and tumor therapeutic agents and triple integration application thereof. The preparation is mainly prepared from dipalmitoyl phosphatidylcholine (DPPC), hollow gold nanoparticles and therapeutic agents. A preparation method of the preparation comprises the following steps: preparing thermosensitive liposome via a conventional method, coating the thermosensitive liposome with the hollow gold nanoparticles by using a film extrusion method, and then coating the thermosensitive liposome with the therapeutic agents. The preparation is capable of reducing toxic and side effects of systemic drug therapy and is also capable of achieving the triple integration therapy effect with combination of drug therapy, thermal therapy and radiation therapy; the tumor killing effect is improved.

The invention discloses intestinal probiotics and application thereof in treating tumors and replacing antibiotics. The lactobacillus reuteri JMR-01 provided by the invention has the preservation number of CGMCC No. 21304. The invention also provides a complex microbial inoculant of the complex microbial inoculant and the following application of the complex microbial inoculant: 1) treatment and/or prevention of tumors; 2) inhibiting of tumor cell proliferation; 3) preventing or treating of diseases caused by pathogenic bacteria; 4) replacing of antibiotics; 5) inhibiting of proliferation of pathogenic bacteria; and 6) promoting or synergistical treating of tumors. The invention provides intestinal probiotics, a method for treating tumors based on the intestinal probiotics and improving the tumor treatment effect by assisting irradiation treatment, and a method for treating tumors by taking the intestinal probiotics as a raw material.

The invention relates to a preparation method, product and application of a molybdenum oxide nano material. The preparation method comprises the steps that 1, molybdenyl acetylacetonate is dissolved into a mixed solution of octadecene, oleic acid and hexadecylamine, and the materials are stirred and react at the temperature of 90-150 DEG C to generate a molybdenum oxide nano intermediate; 2, the mixed solution containing the molybdenum oxide nano intermediate in step 1 continues to be subjected to a hydrothermal reaction to obtain the urchin-like hollow molybdenum oxide nano material. The obtained molybdenum oxide nano material can achieve specific toxicity activation on tumor parts for efficient tumor imaging and treatment, and can also be rapidly degraded in normal tissue to ensure goodbiological safety.

The invention provides a new target for regulating and controlling tumor cell metastasis and an application thereof; the application is an application of a DcR3 inhibitor in preparation of medicines for reducing or eliminating tumor cell metastasis. The invention discloses a new mechanism of the DcR3 in regulation and control of tumor metastasis, and the DcR3 is clear and definite to be used as an anti-tumor migration target; through studies, the DcR3 is indicated to be capable of regulating and controlling expression of crucial molecule E-cadherins in an EMT generation process, promote tumor cytoskeleton remodeling, and then promote the migration of tumor cells. In general, the application can reduce or alleviate malignant tumor metastasis, thereby playing a role in improving the effect of tumor therapy.

The invention relates to an anti-tumor drug and a preparation method thereof. The anti-tumor drug consists of the following components in parts by weight: 0.1-0.3 parts by weight of betulin, 20-30 parts by weight of dendrobium nobile and 5-10 parts by weight of ginseng. The preparation method of the anti-tumor drug comprises the following steps: crushing the dendrobium nobile into powder, so that dendrobium nobile powder is obtained; crushing the ginseng into powder, so that ginseng powder is obtained; and weighing 0.1-0.3 parts by weight of betulin, 20-30 parts by weight of the dendrobium nobile powder and 5-10 parts by weight of the ginseng powder, and uniformly mixing the materials, so that the anti-tumor drug is obtained. The anti-tumor drug and the preparation method thereof disclosed by the invention have the advantages of being good in therapeutic effect, rapid to take effects, simple in preparation method and the like.

The invention discloses a method for preparing oxidation reduction sensitive nanometer targeting carriers, and belongs to the technical field of biomedicine and nanometer materials. By the aid of the method, problems of poor active targeting performance, deposition and adverse reaction due to in-vivo non-degradation, low carried medicine release control efficiency and the like of existing tumor carriers can be solved. The method is used for preparing the organic-inorganic medicine carrying matrix combined oxidation reduction sensitive nanometer targeting carriers with high sensitivity to pH (potential of hydrogen) value of tumor cells and reducible environments. The method includes synthesizing calcium phosphate particles by the aid of micro-emulsion technologies and coating a layer of degradable organic macromolecular substances on the surface of each particle to form a medicine carrying core; assembling reducible environment sensitive cross-linking elements onto the medicine carrying cores, then grafting modified targeting factors and ultimately synthesizing the intelligent targeting nanometer micro-sphere carriers. The method has the advantages that the micro-sphere carriers have powerful targeting functions and are intelligent in medicine release control, stable in structure and free of toxic and side effects, and the like.