Synergistically reinforced anti-tumor near-infrared photoresponsive nanocomposites

A nanocomposite material and near-infrared photoresponse technology, which is applied in the field of nanomaterials, can solve problems such as poor tissue penetration ability, healthy cell toxicity, and limited application, and achieve good thermal stability, anti-tumor effect, and improved response effect. Effect

Inactive Publication Date: 2019-01-18
赵兵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, UV light has poor tissue penetration and is toxic to healthy cells, which limit the further application of most NO donors in vivo.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: (1) RBS ([NH 4 ][Fe 4 S 3 (NO) 7 ]) Slowly added to 1g / L NaYF 4 :Yb,Er-NH 2 In the ethanol dispersion, the RBS and NaYF 4 :Yb,Er-NH 2 The mass ratio is 0.5, reacted at room temperature for 24h, centrifuged, washed and dried to obtain NaYF 4 :Yb,Er-NH 2 / RBS nanocomposites. (2) Add the above NaYF 4 :Yb,Er-NH 2 / RBS nanocomposite was slowly added to 1g / L of HBP-NH 2 In aqueous solution, the NaYF 4 :Yb,Er-NH 2 / RBS with HBP-NH 2 The mass ratio is 1, reacted at room temperature for 24 hours, centrifuged, washed and dried to obtain NaYF 4 :Yb,Er-NH 2 / RBS / HBP-NH 2 nanocomposites. (3) Slowly add GO to 1g / L NaYF 4 :Yb,Er-NH 2 / RBS / HBP-NH 2 In the nanocomposite aqueous solution, the NaYF 4 :Yb,Er-NH 2 / RBS / HBP-NH 2 The mass ratio to GO was 1, reacted at room temperature for 24 hours, centrifuged, washed and dried to obtain NaYF 4 :Yb,Er-NH 2 / RBS / GO nanocomposites. (4) Combine 0.1mol / L BNN6 with 0.1mol / L NaYF 4 :Yb,Er-NH 2 / RBS / GO nanoc...

Embodiment 2

[0013] Embodiment 2: (1) RBS ([NH 4 ][Fe 4 S 3 (NO) 7 ]) Slowly added to 5g / L NaYF 4 :Yb,Er-NH 2 In the ethanol dispersion, the RBS and NaYF 4 :Yb,Er-NH 2 The mass ratio is 1, reacted at room temperature for 24 hours, centrifuged, washed and dried to obtain NaYF 4 :Yb,Er-NH 2 / RBS nanocomposites. (2) Add the above NaYF 4 :Yb,Er-NH 2 / RBS nanocomposite was slowly added to 10g / L of HBP-NH 2 In aqueous solution, the NaYF 4 :Yb,Er-NH 2 / RBS with HBP-NH 2The mass ratio is 4, reacted at room temperature for 24h, centrifuged, washed and dried to obtain NaYF 4 :Yb,Er-NH 2 / RBS / HBP-NH 2 nanocomposites. (3) Slowly add GO to 5g / L NaYF 4 :Yb,Er-NH 2 / RBS / HBP-NH 2 In the nanocomposite aqueous solution, the NaYF 4 :Yb,Er-NH 2 / RBS / HBP-NH 2 The mass ratio to GO was 2, reacted at room temperature for 24 hours, centrifuged, washed and dried to obtain NaYF 4 :Yb,Er-NH 2 / RBS / GO nanocomposites. (4) Combine 5mol / L BNN6 with 5mol / L NaYF 4 :Yb,Er-NH 2 / RBS / GO nanocomposi...

Embodiment 3

[0014] Embodiment 3: (1) RBS ([NH 4 ][Fe 4 S 3 (NO) 7 ]) Slowly added to 10g / L NaYF 4 :Yb,Er-NH 2 In the ethanol dispersion, the RBS and NaYF 4 :Yb,Er-NH 2 The mass ratio is 3, reacted at room temperature for 24h, centrifuged, washed and dried to obtain NaYF 4 :Yb,Er-NH 2 / RBS nanocomposites. (2) Add the above NaYF 4 :Yb,Er-NH 2 / RBS nanocomposite was slowly added to 50g / L of HBP-NH 2 In aqueous solution, the NaYF 4 :Yb,Er-NH 2 / RBS with HBP-NH 2 The mass ratio is 8, reacted at room temperature for 24h, centrifuged, washed and dried to obtain NaYF 4 :Yb,Er-NH 2 / RBS / HBP-NH 2 nanocomposites. (3) Slowly add GO to 10g / L NaYF 4 :Yb,Er-NH 2 / RBS / HBP-NH 2 In the nanocomposite aqueous solution, the NaYF 4 :Yb,Er-NH 2 / RBS / HBP-NH 2 The mass ratio to GO was 5, reacted at room temperature for 24 hours, centrifuged, washed and dried to obtain NaYF 4 :Yb,Er-NH 2 / RBS / GO nanocomposites. (4) Combine 10mol / L BNN6 with 10mol / L NaYF 4 :Yb,Er-NH 2 / RBS / GO nanocomposi...

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PUM

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Abstract

The invention discloses a synergistically reinforced anti-tumor near-infrared photoresponsive NaYF4: Yb, Er-NH2/RBS/GO/BNN6 nanocomposites, NaYF4: Yb, Er-NH2 layer, NO donor RBS layer, GO layer, NO donor BNN6 layer. The NaYF4: Yb, Er-NH2/RBS/GO/BNN6 nanocomposites have good thermal stability and high near-infrared response. NO emission can be triggered and controlled effectively by the switching of near infrared laser, the adjustment of irradiation time and power density. NaYF4: Yb, Er and GO, NO donors RBS and BNN6 can play a synergistic role, greatly enhance the response to near-infrared light, can significantly improve the therapeutic effect of tumor, showing a synergistic enhancement of the anti-tumor effect.

Description

technical field [0001] The invention relates to a near-infrared light-responsive NaYF that synergistically enhances anti-tumor 4 :Yb,Er-NH 2 / RBS / GO / BNN6 nanocomposite material belongs to the field of nanomaterials. Background technique [0002] Nitric oxide (NO) is an endogenous diatomic molecule that plays a key regulatory role in many physiological and pathological processes, including vascular smooth muscle relaxation, immune response, neurotransmission, respiration, and apoptosis. The physiological regulation of NO is largely dependent on the location, time and dose of NO release. It is of great significance to develop a nano-transport platform that can store NO and release the required amount of NO at a specified place and time (Acta Physicochemical Sinica, 2017, 33(05):903-917). [0003] Exogenous NO donors currently include azodiolene, nitrosothiol, nitrobenzene, and metal nitrosyl compounds. NO transport materials include liposomes, silica nanoparticles, quantum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/52A61P35/00
CPCA61K41/0052A61K47/52A61P35/00
Inventor 赵兵
Owner 赵兵
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