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Tumor drug-resistant target site and application of tumor drug-resistant target site

A tumor and drug resistance technology, applied in antitumor drugs, medical preparations containing active ingredients, drug combinations, etc., can solve the problem of chemotherapy drug resistance affecting tumor treatment effect, etc., to relieve pain, improve effect, reduce effect of dosage

Inactive Publication Date: 2016-04-20
SUZHOU UNIV
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Problems solved by technology

However, tumor resistance to chemotherapeutic drugs has become a major obstacle affecting the efficacy of tumor therapy

Method used

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  • Tumor drug-resistant target site and application of tumor drug-resistant target site

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Embodiment Construction

[0020] In order to make the above objects, features and advantages of the present invention more obvious and comprehensible, specific embodiments of the present invention will be described in detail below in conjunction with specific embodiments.

[0021] In the following description, a lot of specific details are set forth in order to fully understand the present invention, but the present invention can also be implemented in other ways different from those described here, and those skilled in the art can do it without departing from the meaning of the present invention. By analogy, the present invention is therefore not limited to the specific examples disclosed below.

[0022] Second, "one embodiment" or "an embodiment" referred to herein refers to a specific feature, structure or characteristic that may be included in at least one implementation of the present invention. "In one embodiment" appearing in different places in this specification does not all refer to the same ...

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Abstract

The invention discloses a tumor drug-resistant target site and application of the tumor drug-resistant target site. The invention discloses influence of NAC1 (Nucleus Accumbens-1) on tumor medicine treatment, and thus provides a purpose of an NAC1 inhibitor in medicine for reducing or eliminating tumor chemotherapy drug resistance and application of the NAC1 inhibitor as a tumor drug-resistant mark and a drug-resistant tumor prediction and diagnosis and drug-resistant tumor medicine design and screening target. The invention provides a novel mechanism for overcoming tumor drug resistance and improving the curative effect, and provides a novel target for resisting tumor drug resistance.

Description

technical field [0001] The invention belongs to the field of molecular biology and tumor prevention and treatment, more specifically, the invention relates to the field of prediction, diagnosis and treatment of tumor drug resistance. Background technique [0002] Malignant tumors are a class of diseases that endanger human health. Chemotherapy is one of the main methods for treating malignant tumors. However, tumor resistance to chemotherapeutic drugs has become a major obstacle affecting the efficacy of tumor therapy. The research on the mechanism of tumor drug resistance and the search and development of drugs to reverse drug resistance are the key and difficult points in the field of cancer prevention and treatment. [0003] BTB / POZ family gene NACC1 gene encodes the expression of cell transcription factor NAC1 (nucleus accumbens-1, nucleus accumbens-1), which is located in the human chromosome region Ch19p13.2. NAC1 is overexpressed in a variety of tumors (such as ovar...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K39/395A61K31/7088A61K48/00A61P35/00G01N33/48
Inventor 张熠杨金铭张丽镇学初
Owner SUZHOU UNIV
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