Hollow manganese dioxide nano-particle as well as preparation method and application thereof

A technology of manganese dioxide and nanoparticles, which is applied in the field of nanomaterials, can solve the problems of restricting the application of hollow manganese dioxide nanoparticles, and achieve the effect of improving the effect of tumor treatment, the preparation method is simple and efficient, and the preparation method is simple and easy.

Inactive Publication Date: 2018-09-14
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, there are few reports on the preparation method of hollow manganese dioxide nanoparticles, which limits the further application of hollow manganese dioxide nanoparticles in the field of tumor diagnosis and treatment.

Method used

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  • Hollow manganese dioxide nano-particle as well as preparation method and application thereof
  • Hollow manganese dioxide nano-particle as well as preparation method and application thereof
  • Hollow manganese dioxide nano-particle as well as preparation method and application thereof

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preparation example Construction

[0043] Because the existing nano-manganese dioxide preparation method is difficult to effectively control the size and structure of nanoparticles, thereby limiting the application of nano-manganese dioxide in biomedicine, the primary purpose of the present invention is to provide a method that can control nano-manganese dioxide. The preparation method of hollow nano manganese dioxide with particle size and structure, the basic steps and reaction mechanism of the method of the present invention are as follows: firstly, silver nanocube is prepared by sulfide-assisted polyol reduction method, and then silver nanocube is used as template, polyacrylamine Hydrochloride is used as a stabilizer, and potassium permanganate is used as an oxidant to grow manganese dioxide shells on the surface of silver nanocubes. During this process, silver nanocubes are oxidized to form silver chloride nanoparticles, which are removed by centrifugation, and the resulting product That is, hollow manganes...

Embodiment 1

[0078] (1) Preparation of silver nanocubes

[0079] ① Add 5mL of ethylene glycol into a 100mL round bottom flask, place it in an oil bath at 150°C and heat it with magnetic stirring. After the temperature of ethylene glycol reaches 150°C, immediately inject 0.06mL of 3mM sodium hydrosulfide-ethylene glycol solution;

[0080] ②After 2 minutes, add 0.5mL of 3mM hydrochloric acid-ethylene glycol solution and 1.25mL of 20mg / mL polyvinylpyrrolidone-ethylene glycol solution;

[0081] ③ After 2 minutes, add 0.4 mL of silver trifluoroacetate-ethylene glycol solution with a concentration of 282 mM. Then keep the temperature of the reaction solution at 150°C for 45 minutes;

[0082] ④ Centrifuge the obtained silver nanocubes at 10,000rpm for 10min, remove the supernatant, and wash them once with acetone, ethanol and ultrapure water respectively to obtain silver nanocubes. figure 1 shown;

[0083] Finally, disperse the purified silver nanocubes in 5mL ultrapure water for subsequent u...

Embodiment 2

[0089] In order to simulate the presence of hydrogen peroxide and acidic microenvironment in tumor tissue, the hollow manganese dioxide nanoparticles in Example 1 were mixed with phosphate buffered saline (PBS) with 0.03% hydrogen peroxide and pH=6.4, with 4, 7-diphenyl-1,10-phenanthroline ruthenium complex (Ru(dpp) 3 Cl 2 ) fluorescent probes to detect oxygen generated by the reaction of hollow manganese dioxide nanoparticles with acidic hydrogen peroxide solution.

[0090] Depend on image 3 The test results shown show that as the reaction time increases, the amount of oxygen produced by the hollow manganese dioxide nanoparticles increases, and the generated oxygen can improve the hypoxic microenvironment of the tumor, and the released manganese ions can generate magnetic resonance imaging signals , can be used in magnetic resonance imaging, so that accurate diagnosis and efficient treatment of tumors can be realized.

[0091] The preparation method of the present inventi...

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Abstract

The invention provides a hollow manganese dioxide nano-particle as well as a preparation method and application thereof. The preparation method comprises: a silver nanocube is first prepared, and thenthe silver nanocube is used as a template, and the hollow manganese dioxide nano-particle is synthesized with a template method in a one-step process; the hollow manganese dioxide nano-particle has the characteristics of being simple in preparation process and the like; at the same time, the hollow manganese dioxide nano-particle, prepared with the method, has the advantages of stable properties,controllable size and structure and the like, and can be applied in the fields of drug carriers, tumor treatment, magnetic resonance imaging and the like.

Description

technical field [0001] The invention relates to the field of nanomaterials, in particular to hollow manganese dioxide nanoparticles, a preparation method and application thereof. Background technique [0002] Manganese dioxide is an important transition metal oxide. Due to its good redox properties, it has been widely used in many fields such as battery materials. [0003] In addition to the characteristics of manganese dioxide, nano-manganese dioxide also has special nano-effects, so its application has been further expanded. Reductive glutathione degradation; or react with hydrogen peroxide in the body to generate oxygen, which can regulate the acidity, hypoxia and redox microenvironment of solid tumors, and can improve the efficacy of chemotherapy, radiotherapy or photodynamic therapy; at the same time , the manganese ions released by the degradation of manganese dioxide can also realize magnetic resonance imaging, so manganese dioxide nanoparticles have important applic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G45/02B82Y40/00A61K33/32A61K47/02A61K49/18A61P35/00
CPCA61K33/32A61K47/02A61K49/183C01G45/02C01P2004/04C01P2004/34C01P2004/64
Inventor 蔡林涛梁锐晶韩志群郑明彬
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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