Porphyrin-based metal organic framework nano-carrier with sonodynamic combined starvation therapy anti-tumor function and preparation method of porphyrin-based metal organic framework nano-carrier

Abstract

The invention discloses a porphyrin-based metal organic framework nano-carrier with a sonodynamic combined starvation therapy anti-tumor function and a preparation method of the porphyrin-based metal organic framework nano-carrier. The preparation method comprises the following steps: dissolving a porphyrin-based ligand and metal salt in a solvent, and heating to obtain porphyrin-based metal organic framework particles; and dispersing the porphyrin-based metal organic framework particles into water, adding high-valence metal acid or high-valence metal salt and a reducing agent, and mixing with a cell membrane and glucose oxidase to obtain the cell membrane modified porphyrin-based metal organic framework nano-carrier loaded with the metal nanoparticles and the glucose oxidase. The nano-carrier can enhance the accumulation at the tumor site and improve the tumor targeted hunger treatment effect; and meanwhile, tumor hypoxia is relieved, sonodynamic reaction substrates are increased, and the sonodynamic effect is improved. The preparation process is simple and controllable, the material source is wide, and scale amplification can be realized; and in vivo, good stability and tumor sonodynamic and hunger treatment combined treatment effect are achieved, and good application prospects are achieved in the field of tumor treatment.

Description

technical field [0001] The invention belongs to the field of preparation of anti-tumor nanomaterials, and relates to a porphyrin-based metal-organic framework nano-carrier with the anti-tumor function of sonodynamic combined with starvation therapy and a preparation method thereof. Background technique [0002] Due to the increasing morbidity and mortality, tumor has become a major killer of human health. Excessive production of reactive oxygen species (ROS) in local tumors can cause apoptosis and necrosis of tumor tissue, and finally achieve the effect of tumor killing. Ultrasound-based sonodynamic therapy has the advantages of low cost, convenient use, deep penetration, and non-invasiveness, and has broad potential application prospects in tumor treatment. However, the sonosensitizer is easily eliminated in the body quickly, the accumulation of tumor tissue is small, there is a self-quenching effect, and the sonodynamic effect is not satisfactory. In addition, the hypoxi...

AI Technical Summary

Problems solved by technology

However, the sonosensitizer is easily eliminated quickly in the body, the accumulation of tumor tissue is small, there is a self-quenching effect, and the sonodynamic effect is not satisfactory

In addition, the hypoxic microenvironment at the tumor site cannot provide enough oxygen for sonodynamic therapy, which also reduces the effect of sonodynamic therapy in tumor killing.

[0003] At present, various nanocarriers have been designed to load hydrophobic sonosensitizers in mesoporous or hollow structures, but there are still problems of low loading capacity, less tumor accumulation of sonosensitizers, and insufficient oxygen, resulting in the effect of sonodynamic therapy. Poor, there is an urgent need to optimize the preparation of sonosensitizers and develop synergistic tumor therapy strategies

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