Preparation method, product and application of molybdenum oxide nano material

A nanomaterial, molybdenum oxide technology, applied in the direction of molybdenum oxide/molybdenum hydroxide, heavy metal active ingredients, drug combinations, etc., can solve the problems of limiting the wide application of photothermal therapy, poor patient adaptability, etc., and achieve a good possibility of clinical transformation. , controllable conditions, improve the effect of tumor treatment

Active Publication Date: 2019-04-19
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the tissue-attenuating properties and poor patient adaptability of near-infrared light limit the widespread application of photothermal therapy

Method used

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  • Preparation method, product and application of molybdenum oxide nano material
  • Preparation method, product and application of molybdenum oxide nano material
  • Preparation method, product and application of molybdenum oxide nano material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] (1) Disperse 80 mg of molybdenum acetylacetonate, 0.2 g of hexadecylamine and 2 ml of oleic acid in 8 ml of octadecene, heat and stir at 100° C. for 10 min to generate a molybdenum oxide nano-intermediate.

[0049] (2) Transfer the mixture in step (1) to a 15ml high-pressure hydrothermal kettle, heat it to 200°C, and after 12 hours of reaction, take out the hydrothermal kettle and cool it to room temperature, collect the precipitate by ethanol centrifugation, and centrifuge to obtain a sea urchin-shaped hollow Molybdenum oxide nanomaterials (MoO 3-x NUs), and washed three times with absolute ethanol and dispersed in chloroform.

[0050] The morphology of sea urchin-like hollow molybdenum oxide nanomaterials was characterized by TEM, and the results are shown in the attached figure 1 As shown, the particle size is in the range of 300-500nm.

Embodiment 2

[0052] (1) Disperse 100 mg of molybdenum acetylacetonate, 0.2 g of hexadecylamine and 2 ml of oleic acid in 8 ml of octadecene, heat and stir at 120° C. for 10 min to generate a molybdenum oxide nano-intermediate.

[0053] (2) Transfer the mixture in step (1) to a 15ml high-pressure hydrothermal kettle, heat it to 180°C, and after 12 hours of reaction, take out the hydrothermal kettle and cool it to room temperature, collect the precipitate by ethanol centrifugation, and centrifuge to obtain a sea urchin-shaped hollow Molybdenum oxide nanomaterials (MoO 3-x NUs), and washed three times with absolute ethanol and then dispersed in chloroform, the obtained sea urchin-like hollow molybdenum oxide nanomaterials had a size of 300-600 nm.

Embodiment 3

[0055] (1) Disperse 120 mg of molybdenum acetylacetonate, 0.2 g of hexadecylamine and 4 ml of oleic acid in 8 ml of octadecene, heat and stir at 100° C. for 20 minutes to generate a molybdenum oxide nano-intermediate.

[0056] The intermediate product molybdenum oxide nano-intermediate was characterized by TEM and XPS respectively. TEM characterization as figure 2 As stated above, it is proved that the intermediate product is a nano-scale particle with a particle diameter of 200-400nm. XPS characterization as image 3 As shown, it proves that part of the hexavalent molybdenum has been reduced to pentavalent molybdenum during the heating process.

[0057] (2) Transfer the mixture in step (1) to a 15ml high-pressure hydrothermal kettle, heat it to 160°C, and after 12 hours of reaction, take out the hydrothermal kettle and cool it to room temperature, collect the precipitate by ethanol centrifugation, and centrifuge to obtain a sea urchin-shaped hollow Molybdenum oxide nanoma...

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Abstract

The invention relates to a preparation method, product and application of a molybdenum oxide nano material. The preparation method comprises the steps that 1, molybdenyl acetylacetonate is dissolved into a mixed solution of octadecene, oleic acid and hexadecylamine, and the materials are stirred and react at the temperature of 90-150 DEG C to generate a molybdenum oxide nano intermediate; 2, the mixed solution containing the molybdenum oxide nano intermediate in step 1 continues to be subjected to a hydrothermal reaction to obtain the urchin-like hollow molybdenum oxide nano material. The obtained molybdenum oxide nano material can achieve specific toxicity activation on tumor parts for efficient tumor imaging and treatment, and can also be rapidly degraded in normal tissue to ensure goodbiological safety.

Description

technical field [0001] The invention relates to the field of preparation of molybdenum oxide, in particular to a preparation method, product and application of a molybdenum oxide nano material. Background technique [0002] Tumor has become one of the major diseases that seriously threaten human health. According to the research report of the International Agency for Research on Cancer (IARC) under the World Health Organization (WHO), there were 18.1 million newly diagnosed cases of cancer in the world in 2018, and Asia accounted for 48.4% of the world's new cancer patients. [0003] At present, the tumor targeting efficiency of anti-tumor nanomaterials is still low (usually less than 1%), resulting in poor tumor killing effect and obvious toxic side effects on normal cells. Even if the administration method is intratumoral injection, the diffusion of anti-tumor nanomaterials to surrounding normal tissues will cause unpredictable toxicity problems. Anti-tumor nanomaterials...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G39/02A61K33/24A61P35/00
CPCA61K33/24A61P35/00C01G39/02C01P2002/01C01P2002/80C01P2002/85C01P2004/62C01P2006/12
Inventor 凌代舜李方园胡希
Owner ZHEJIANG UNIV
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