101results about How to "Good drug loading performance" patented technology

The invention relates to a method for preparing a nano-cellulose antibacterial composite material through on-line culture. The method comprises the following steps of: (1) inoculating an activated bacterial cellulose producing strain into a liquid culture medium, performing amplification culture, transferring the liquid culture medium into a bioreactor, culturing, adding an antibacterial material into the liquid culture medium, and continuing to culture to obtain an unpurified antibacterial bacterial cellulose composite material; and (2) peeling a bacterial cellulose membrane from a framework or directly soaking the composite material in a NaOH solution, treating in water bath, and washing until an obtained product is neutral to obtain the nano-cellulose antibacterial composite material. The preparation efficiency is high, and the method is simple, convenient, feasible and low in cost; and the surface of the bacterial cellulose composite material has a nanoscale three-dimensional fibrous mesh-shaped structure, the tensile strength of the material is greatly improved compared with that of a pure bacterial cellulose membrane, and the material can be widely applied to products such as facial masks, wound dressings, plasters, artificial skins and the like.

The invention belongs to the technical field of biomedical nanomaterials, and discloses a pH-responsive schiff base copolymer-coated mesoporous silica drug-loaded nanoparticle as well as a preparationmethod and application thereof. The nanoparticle provided by the invention comprises a mesoporous silica nanoparticle, a drug loaded inside the mesoporous silica nanoparticle, and a polymer modifiedon a surface of the mesoporous silica nanoparticle; and the polymer modified on a surface of the mesoporous silica nanoparticle is specifically P (PEGMA-co-MAEBA) modified on the surface of the mesoporous silica nanoparticle by an imine bond. The nanoparticle material provided by the invention has good biocompatibility, and realizes controlled release of the drug by utilizing an acid-sensitive imine bond; the drug is hardly released around normal cells, but the imine bond is broken in a slightly acidic environment of tumor cells, and the polymer falls off to rapidly release the drug, thereby realizing targeted therapy for the tumors; and the nanoparticle material is applicable to the field of controlled release of drugs.

The invention discloses a preparation method of a fibroin and graphene oxide composite bracket material. The preparation method comprises the steps of: performing dissolution, filtration, dialysis and centrifugation on degumming fibrous fibroin in sequence, and then condensing to obtain a silk fibroin aqueous solution; dispersing graphene oxide aqueous solution ultrasonically; filtering in a vacuum manner to remove impurities; mixing the graphene oxide aqueous solution with the silk fibroin solution; mixing uniformly; oscillating at the presence of ultrasonic waves for mutual crosslinking; then centrifuging to obtain a mixed solution; then preparing by adopting a freeze-drying method so as to obtain the porous fibroin and graphene oxide composite bracket material. The high-concentration fibroin and the graphene oxide blended aqueous solution has good mixing property, the obtained composite bracket material is excellent in air permeability and drug-carrying ability, is good in hygroscopic property and waste liquid removal effect, and has wide application foreground.

The invention belongs to the technical field of medical biological materials, and particularly relates to a preparation method of a biomedical amino acid-polyether-polyester triblock copolymer. The method comprises the following steps of: initiating lactone ring opening polymerization under a vacuum condition to prepare a polyether-polyester copolymer, and adding a polymer, amino acid, a catalyst and a solvent into a reaction kettle; and reacting to obtain an amino acid-polyether-polyester triblock copolymer, and removing water and the solvent left in a polymerization system to obtain the amino acid-polyether-polyester triblock copolymer. The method is easy to operate and is practicable; reaction conditions are easy to control; and the obtained copolymer has a stable structure, and can be used for entrapping slightly-soluble medicaments to meet the requirements of clinical treatment.

The invention discloses a reversible crosslinked biodegradable polymer vesicle having positive charges on an inner membrane, a preparation method thereof and application in preparation of antineoplastic drugs. The biodegradable polymer vesicle based on tumor targeting of a block polymer PEG-P (TMC-DTC)-SP or PEG-P (LA-DTC)-SP, having the positively charged membrane, reversibly crosslinked in reduction sensitivity and intracellularly solvable and crosslinked can effectively support and protect biological macromolecules such as proteins, DNA and siRNA and micromolecular drugs with negative charges in a physical environment and can be delivered to intravital tumor cells to induce apoptosis. The system has lots of unique advantages including simple and easy controllability of preparation, excellent biocompatibility, excellent controlled drug release property, super-strong in-vivo circulation stability, superior cancerous cell targeting and remarkable cancer cell apoptosis capability and the like. Therefore, the reversible crosslinked biodegradable polymer vesicle is expected to become a simple, stable, multifunctional nano system platform integrating multiple advantages and is used for efficient, active and targeted delivery from nucleic acids to in-situ tumors.

The invention relates to a heparin complex which has the following general formula: Y-X-Y or Y-g-X-g-y or X-Y or X-g-Y, wherein x is poloxamer, g is spacer-arm molecules, Y is heparin, and X, g, Y or X, Y are combined by covalent bonds. The invention also provides a preparation method of the heparin complex. The heparin complex can be applied as pharmaceutical excipients or conveying vectors.

The invention relates to a part-degradable long-acting drug loading polyacrylonitrile fiber and application and a method thereof, which takes polyacrylonitrile as a substrate, polymerized substance and active components which are degradable, soluble and can be swelled are loaded in the fiber, the fiber can control the active components to release slowly and chronically through the stepwise degradation, dissolving or swelling of the polymerized substance, the drug loading fiber can be prepared by adopting various spinning methods, spinning dope is prepared by blending, and spinning liquid comprises the polyacrylonitrile, the active components, the degradable polymerized substance, percutaneous absorption permeation accelerator and the like. The fiber can further be used for preparing multipurpose medicinal textiles, health care textiles, aromatic textiles, drug shims, medicine stickings and treating of skin disease, and the controlled release drug delivery system which carries out the systemic drug through skin or the inhaling mode.

The invention provides a method for preparing an anthracycline antitumor antibiotic oleic acid compound and an oil-water double phase for preparing the compound and albumin, and the anthracycline antitumor antibiotic oleic acid compound is prepared into an albumin nanoparticle preparation. The albumin nanoparticle preparation prepared by the method is little in using amount of auxiliary materials, high in medicine-carrying dose and high in stability, and a preparation process is simple and is suitable for large-scale industrial production; and the albumin nanoparticle preparation has the tumor targeting and good clinical application value.

A bioactive degradable hollow hydroxy apatite microball used as carrier is prepared from porous hydroxy apatite particles through plasma fusing, spraying it in low-temp medium, natural drying, washing, ultrasonic dispersing and collecting.

The invention aims to provide a production technology of high-purity egg yolk lecithin. The invention is also aimed at providing high-purity egg yolk lecithin. The other aim of the invention is to provide an application of the high-purity egg yolk lecithin. The production technology provided by the invention comprises the following steps: using an egg yolk solution as a raw material, using ethanol for extracting and removing impurities, carrying out microwave radiation, adsorbing by the use of an adsorbent, desolventizing, and carrying out vacuum drying to prepare the high-purity egg yolk lecithin. Thus, the production technology better meets requirements on egg yolk lecithin in the medical industry and food industry.

The invention provides an indocyanine green albumin conjugate preparation and a preparation method thereof. An injection mainly contains indocyanine green, albumin and a surfactant. The preparation prepared by the method has tumor targeting, significantly improves drug efficacy and reduces toxicity, and has good biocompatibility, and good stability; and a preparation process is simple, and suitable for industrialized mass production, and has broad application prospects.

The invention belongs to the field of pharmaceutical material and particularly relates to a medical cassava starch composite film prepared by the compounding of cassava starch and a preparation methodthereof; and the preparation method comprises the following steps: simultaneously weighting cassava starch, polyvinyl alcohol and crosslinking agent according to a certain proportion, then dissolvingseparately, mixing the raw materials, spreading film, crosslinking, removing impurities and loading drugs to prepare the medical cassava starch composite film. The composite film of the invention haswide sources of raw materials and cheap price; cassava starch and polyvinyl alcohol are crosslinked to prepare the reinforced and toughened starch composite film so that the composite film has good biocompatibility, drug-loading property and degradability and higher wet strength; and the film can be used for the coating of body surface traumas, burns and the like and the used waste material can be fairly rapidly degraded so that the medical cassava starch composite film can be utilized to develop a kind of environmentally protective medical film material and has better development potential.

The invention provides a targeting hybrid nano-system, a preparation method thereof and an application. The targeting hybrid nano-system comprises lipid bilayer nanospheres, amphipathic polymeric nano-particles, targeting polypeptides and / or antibodies and different medicines, wherein the lipid bilayer nanospheres wrap the amphipathic polymeric nano-particles, the targeting polypeptides and / or antibodies are connected on the surfaces of the lipid bilayer nanospheres, and the amphipathic polymeric nano-particles and the lipid bilayer nanospheres wrap the different medicines. The prepared targeting hybrid nano-system has targeting according to tumor microenvironments and has a space structure of 'a large sphere wrapping a small sphere', small nano-particles in the system have penetrating capacity for deep tumor tissues, the targeting hybrid nano-system can simultaneously wrap various different water-soluble medicines, and multi-drug combination treatment targeting tumor tissues is achieved, so that the targeting hybrid nano-system has the advantages of good specificity and drug loaded effect, moderate drug release speed, multi-drug combination and multi-targeted treatment.

The invention discloses a special drug-loading hot-melt pressure-sensitive adhesive, which is prepared from the following components in parts by weight: 20-45 parts of a styrene-isoprene-styrene block copolymer thermoplastic elastomer, 1-5 parts of acrylic resin, 5-20 parts of styrene-butadiene-styrene block copolymer thermoplastic elastomer, 20-35 parts of a tackifier, 10-15 parts of a plasticizer, 5-12 parts of a bacteriostatic agent, 0.01-1 part of an age resister and the balance of anti-oxidant, wherein the tackifier is a mixture formed by mixing polyvinylpyrrolidone and one of petroleum resin, rosin resin, terpene resin, terpene-styrene resin and coumarone-terpene resin, wherein polyvinylpyrrolidone accounts for over 50% of the weight of the tackifier. The special drug-loading hot-melt pressure-sensitive adhesive is lasting in adhesivity, good in weather resistance and heat resistance, good in antibacterial effect, good in drug-loading effect and low in cost.

The invention relates to a magnetic resonance imaging guided targeting metal organic framework drug carrier preparation method, which comprises: adopting a hydrothermal method to prepare magnetic spheres with carboxyl on the surface, completely and uniformly mixing the magnetic spheres and a metal organic framework synthesis precursor solution, adopting a one-pot method to prepare a magnetic resonance imaging guided metal organic framework drug carrier under a hydrothermal condition, and finally modifying targeting molecules on the metal organic framework so as to obtain the magnetic resonance imaging guided targeting metal organic framework drug carrier. According to the present invention, the drug carrier prepared through the method integrates characteristics of the targeting molecules, the magnetic spheres and the metal organic framework, such that the triple functions such as targeting property, magnetic resonance imaging and drug loading are provided, the magnetic resonance imaging-assisted visualized targeting drug delivery can be achieved, and the difference in the time and in the space during the diagnosis and therapy process is avoided; and the preparation method is simple and easy performing, the scale production is easily achieved, and great development potential and application values are provided in the field of biomedicine and pharmaceutical engineering.

The present invention relates to the field of medicine preparation, in the concrete, it relates to a show-released fibre preparation of water-soluble anti-cancer medicine for body implantation and its preparation method. It is characterized by that the fibre carrier is oil-soluble biological degradable material. and the medicine is water-soluble anticancer medicine, its medicine content is up to 15-50%.

The invention relates to a radiopaque efficient drug-loading embolic microsphere as well as a preparation method and application thereof. Specifically, the invention discloses a radiopaque embolic microsphere. The microsphere is obtained by cross-linking polymerization of a polyhydroxy polymer, an (acetal) derivative of alkyl olefine acid, an alkyl olefine (sulfonic) acid derivative and a halogen-substituted alkyl (sulfonyl) chloride derivative. The microsphere disclosed by the invention has an excellent developing effect and an excellent embolization effect, and the microsphere is excellent in drug loading effect.

The invention discloses a preparation method of a mesoporous silicon dioxide nanomaterial with fluorescent imaging and drug loading functions. The preparation method is used for solving the technicalproblem that the conventional preparation method of the fluorescent silicon dioxide nanomaterial is complicated. The method comprises the steps of preparing a mesoporous silicon dioxide nano particleby taking cetyl trimethyl ammonium bromide as a template and ethyl orthosilicate as a silicon source by a sol gel method, taking 3-aminopropyl triethoxy alkyl as an amination modification reagent to form aminated mesoporous silicon dioxide, allowing chloro fluorescein carboxyfluorescein diacetate succinimidyl ester to be in reaction with aminated mesoporous silicon dioxide to form a chloro fluorescein-labeled mesoporous silicon dioxide nano particle. The drug loading and fluorescent imaging functions are achieved by firmly linking a fluorescent dye onto mesoporous silicon dioxide by an amido bond. The method is simple to operate, and a strongly corrosive reagent is not required.

The invention relates to the technical field of materials, and discloses a coated barium sulfate nanoparticle used for bone cement developer. The coated barium sulfate nanoparticle mainly comprises porous barium sulfate nanoparticles coated on the surface of the porous barium sulfate nanoparticles and loaded with hexa (6-iodo-6-deoxy)-[alpha]-Polydopamine (PDA) coatings of cyclodextrin (I-CD) andsilver (Ag) were prepared to prepare barium sulfate nanoparticles. The invention discloses a coating barium sulfate nanoparticle, which is prepared by adding the coating barium sulfate nanoparticle into polymethyl methacrylate bone cement as a developer, and the preparation method and the use thereof show excellent X-ray diffraction characteristics. The preparation method is simple and can be usedas a new type of developer in bone cement because of its developmental properties, antibacterial properties, biocompatibility, mechanical properties and drug loading and release properties.

The invention discloses a cryogel for stopping bleeding and bearing an anti-cancer drug and a preparation method thereof, the preparation method comprises the following steps: a double bond is modified to a biomacromolecule, a polyphenolic compound is grafted onto the biomacromolecule, and the dopamine molecule and the Zn 2 + ion are coordinated to prepare dopamine-modified ZIF -8; and all the components are respectively prepared into aqueous solutions or dispersion solutions, and then under the action of an initiator, through double-bond polymerization, the multifunctional water / blood triggered shape memory cryogel l is formed at low temperature. According to the preparation method, polysaccharide and other biomacromolecules with good biocompatibility and degradation performance are taken as the basis, the process of chemical grafting of double-bond or polyphenol compounds also has the characteristics of low toxicity and no pollution, the used double-bond functionalized biomacromolecules are simple to prepare, the synthesis technology is mature, and the prepared product has good universality.

The invention discloses a micromolecule drug-loaded polymer vesicle as well as a preparation method and application thereof. The micromolecule drug-loaded polymer vesicle is prepared by assembling anamphiphilic block polymer and a micromolecule drug, or assembling and crosslinking the amphiphilic block polymer and a functionalized amphiphilic block polymer, loading the micromolecule drug, and reacting with the targeting monoclonal antibody. The vesicle system provided by the invention has many unique advantages, including small size, simple and controllable preparation, excellent biocompatibility, high in-vivo cycling stability, strong tumor cell specific selectivity, high intracellular drug release speed, remarkable tumor growth inhibition effect and the like. Therefore, the vesicle system is expected to become a simple nano platform integrating multiple functions, and is used for efficiently and specifically delivering vincristine sulfate to multiple myeloma cells in a targeted manner.

The invention relates to a preparation method, product and application of a molybdenum oxide nano material. The preparation method comprises the steps that 1, molybdenyl acetylacetonate is dissolved into a mixed solution of octadecene, oleic acid and hexadecylamine, and the materials are stirred and react at the temperature of 90-150 DEG C to generate a molybdenum oxide nano intermediate; 2, the mixed solution containing the molybdenum oxide nano intermediate in step 1 continues to be subjected to a hydrothermal reaction to obtain the urchin-like hollow molybdenum oxide nano material. The obtained molybdenum oxide nano material can achieve specific toxicity activation on tumor parts for efficient tumor imaging and treatment, and can also be rapidly degraded in normal tissue to ensure goodbiological safety.

The invention relates to a novel thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system and a preparation method. Chitosan serves as a membrane material, beta-cyclodextrin serves as a clathration material, and a composite microsphere is prepared in a reversed phase suspension-chemical crosslinking method. According to the novel thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system, the composite microsphere carries thymalfasin. According to the novel thymalfasin drug delivery system, the obtained composite microsphere performs good protection and controlled-release functions on the thymalfasin, provides feasibility for oral administration medicines and has good economic benefits and application prospect.

The invention provides a polypeptide. The polypeptide has a structure as shown in a formula (1) described in the specification, wherein m is an integer from 1 to 3, and n is an integer from 3 to 20. The invention further provides a pharmaceutical composition and a preparation method thereof. The preparation method of the pharmaceutical composition comprises the following steps: enabling a medicine compound solution to contact with the polypeptide disclosed by the invention to obtain a contacted material. The pharmaceutical composition obtained by the preparation method of the pharmaceutical composition disclosed by the invention can simultaneously realize good medicine carrying effects, moderate medicine release speed, good stability and good biocompatibility.

The invention belongs to the technical field of embolism microsphere preparation, and particularly relates to a preparation method of narrow-particle-size polyvinyl acetate embolism microspheres with controllable drug loading performance. Vinyl acetate monomers are used as raw materials, and a free radical polymerization method and a suspension emulsion polymerization method are effectively combined to prepare the polyvinyl acetate embolization microsphere with the characteristics of good drug loading performance and narrow particle size distribution, and the defects that the current DEB-TACE microsphere product is low in drug loading capacity and wide in particle size distribution range are overcome. The preparation process is simple, the raw material cost is low, and the yield is high; the phase proportion and crystallinity of partially hydrolyzed polyvinyl acetate are controllable; the drug loading process is simple, the applicable drug range is wide, and the drug loading capacity is large; and the drug release process is easy to control, and the burst release phenomenon can be effectively inhibited.

The invention relates to a cyclic polycaprolactone-polyethylene glycol amphipathic block copolymer, the structural formula of which is as shown in the specification, wherein n is equal to 10-100, and m is equal to 20-200. The invention further discloses a preparation method of the cyclic polycaprolactone-polyethylene glycol amphipathic block copolymer. The preparation method comprises the following steps: mixing cyclic polycaprolactone with two ends terminated by alkynyl, with polyethylene glycol with one end terminated by azide group, and reacting by adopting a CuAAC method to obtain the cyclic polycaprolactone-polyethylene glycol amphipathic block copolymer. The invention further discloses applications of the cyclic polycaprolactone-polyethylene glycol amphipathic block copolymer as a drug carrier. The block copolymer contains cyclic PCL, has different amphipathic chain segment rations, and can entrap drugs by utilizing the topological structure of cyclic PCL.

The invention relates to a method for preparing recombinant human growth hormone entrapped sustained-release drug microcapsules. According to the method, a degradable multi-arm polyethylene glycol-polylactic acid block polymer material with good biocompatibility is taken as a vector material, and raw materials are easily obtained; the multi-arm polymer has relatively small hydrodynamic volume and relatively low viscosity, and the degradation rate of the multi-arm polymer is higher than that of linear polymers, so that the loading and delivery of drugs are more facilitated; a multi-arm polyethylene glycol-polylactic acid block copolymer has good drug loading capacity and unique amphiphilicity, so that protein adsorption can be prevented, the recognition and phagocytosis of a reticuloendothelial system are avoided, and the physiological barrier is easy to pass; the method disclosed by the invention is simple and does not need a complicated re-emulsion formation process; the microcapsules are good in stability, the bioavailability of recombinant human growth hormone is improved, and the content of the recombinant human growth hormone reaches up to 46-81%; the entrapment rate of the recombinant human growth hormone entrapped sustained-release drug microcapsules reaches 91%, the stability is good, the grain size is uniform, and the repeatability is good, so that the recombinant human growth hormone entrapped sustained-release drug microcapsules are suitable for large-scale production.

The invention discloses an antitumor drug and a preparation method thereof. The antitumor drug is based on block polymer PEG-P (TMC-DTC)-SP or PEG-P (LA-DTC)-SP tumor targeting and has reduction-sensitive reversible crosslinking and intracellular-soluble crosslinking biodegradable polymeric vesicles with positively-charged internal membranes, and micromolecular drugs, which can be used for protecting biological macromolecules such as protein, DNA and siRNA and have negatively-charged physiological environments, can be efficiently loaded and can be conveyed into in-vivo tumor cells to induce the apoptosis of the tumor cells. The system has a variety of unique advantages, including simplicity and control in preparation, outstanding biocompatibility, excellent drug controlled release, superhigh in-vivo cycle stability, superior cancer cell targeted performance, remarkable cancer cell apoptosis capability and the like. Therefore, the antitumor drug advantageously becomes a nano-system platform integrating the advantages of simplicity, stability, multifunction and the like and is used for efficiently and actively conveying nucleic acid to in-situ tumors in a targeted manner.

The invention provides a method for preparing mesoporous silica nanoparticles with a coumarin optically controlled molecular switch by thiol-ene click chemistry. The method comprises the following steps: a coumarin derivative whose side chain contains a double bond is dissolved in a certain solvent, siloxane containing a mercapto group is added, a reaction is carried out in a proper condition with initiation of light or a free radical generating agent, and a silanization reagent containing a coumarin ring structure is prepared. The silanization reagent is grafted to mesoporous silica nanoparticles, and the mesoporous silica nanoparticles with the coumarin optically controlled molecular switch are obtained. The mesoporous silica nanoparticles with the coumarin optically controlled molecular switch are used for controlled release of medicaments.

The invention relates to the field of medical supplies, and particularly relates to a manufacturing method of water-soluble bamboo-fiber hemostatic gauze. The method comprises five procedures of pretreatment, an alkali reaction, an ether reaction, washing treatment and post treatment. The manufacturing method is a method for producing hemostatic gauze, which is simple in production process, relatively few in the kinds of used raw materials and reagents, and further better in effects, particularly in degradation effects.