101results about How to "Good drug loading performance" patented technology

The invention relates to a method for preparing a nano-cellulose antibacterial composite material through on-line culture. The method comprises the following steps of: (1) inoculating an activated bacterial cellulose producing strain into a liquid culture medium, performing amplification culture, transferring the liquid culture medium into a bioreactor, culturing, adding an antibacterial material into the liquid culture medium, and continuing to culture to obtain an unpurified antibacterial bacterial cellulose composite material; and (2) peeling a bacterial cellulose membrane from a framework or directly soaking the composite material in a NaOH solution, treating in water bath, and washing until an obtained product is neutral to obtain the nano-cellulose antibacterial composite material. The preparation efficiency is high, and the method is simple, convenient, feasible and low in cost; and the surface of the bacterial cellulose composite material has a nanoscale three-dimensional fibrous mesh-shaped structure, the tensile strength of the material is greatly improved compared with that of a pure bacterial cellulose membrane, and the material can be widely applied to products such as facial masks, wound dressings, plasters, artificial skins and the like.

The invention discloses a preparation method of a fibroin and graphene oxide composite bracket material. The preparation method comprises the steps of: performing dissolution, filtration, dialysis and centrifugation on degumming fibrous fibroin in sequence, and then condensing to obtain a silk fibroin aqueous solution; dispersing graphene oxide aqueous solution ultrasonically; filtering in a vacuum manner to remove impurities; mixing the graphene oxide aqueous solution with the silk fibroin solution; mixing uniformly; oscillating at the presence of ultrasonic waves for mutual crosslinking; then centrifuging to obtain a mixed solution; then preparing by adopting a freeze-drying method so as to obtain the porous fibroin and graphene oxide composite bracket material. The high-concentration fibroin and the graphene oxide blended aqueous solution has good mixing property, the obtained composite bracket material is excellent in air permeability and drug-carrying ability, is good in hygroscopic property and waste liquid removal effect, and has wide application foreground.

The invention belongs to the technical field of medical biological materials, and particularly relates to a preparation method of a biomedical amino acid-polyether-polyester triblock copolymer. The method comprises the following steps of: initiating lactone ring opening polymerization under a vacuum condition to prepare a polyether-polyester copolymer, and adding a polymer, amino acid, a catalyst and a solvent into a reaction kettle; and reacting to obtain an amino acid-polyether-polyester triblock copolymer, and removing water and the solvent left in a polymerization system to obtain the amino acid-polyether-polyester triblock copolymer. The method is easy to operate and is practicable; reaction conditions are easy to control; and the obtained copolymer has a stable structure, and can be used for entrapping slightly-soluble medicaments to meet the requirements of clinical treatment.

The invention relates to a part-degradable long-acting drug loading polyacrylonitrile fiber and application and a method thereof, which takes polyacrylonitrile as a substrate, polymerized substance and active components which are degradable, soluble and can be swelled are loaded in the fiber, the fiber can control the active components to release slowly and chronically through the stepwise degradation, dissolving or swelling of the polymerized substance, the drug loading fiber can be prepared by adopting various spinning methods, spinning dope is prepared by blending, and spinning liquid comprises the polyacrylonitrile, the active components, the degradable polymerized substance, percutaneous absorption permeation accelerator and the like. The fiber can further be used for preparing multipurpose medicinal textiles, health care textiles, aromatic textiles, drug shims, medicine stickings and treating of skin disease, and the controlled release drug delivery system which carries out the systemic drug through skin or the inhaling mode.

A bioactive degradable hollow hydroxy apatite microball used as carrier is prepared from porous hydroxy apatite particles through plasma fusing, spraying it in low-temp medium, natural drying, washing, ultrasonic dispersing and collecting.

The invention aims to provide a production technology of high-purity egg yolk lecithin. The invention is also aimed at providing high-purity egg yolk lecithin. The other aim of the invention is to provide an application of the high-purity egg yolk lecithin. The production technology provided by the invention comprises the following steps: using an egg yolk solution as a raw material, using ethanol for extracting and removing impurities, carrying out microwave radiation, adsorbing by the use of an adsorbent, desolventizing, and carrying out vacuum drying to prepare the high-purity egg yolk lecithin. Thus, the production technology better meets requirements on egg yolk lecithin in the medical industry and food industry.

The invention provides an indocyanine green albumin conjugate preparation and a preparation method thereof. An injection mainly contains indocyanine green, albumin and a surfactant. The preparation prepared by the method has tumor targeting, significantly improves drug efficacy and reduces toxicity, and has good biocompatibility, and good stability; and a preparation process is simple, and suitable for industrialized mass production, and has broad application prospects.

The invention belongs to the field of pharmaceutical material and particularly relates to a medical cassava starch composite film prepared by the compounding of cassava starch and a preparation methodthereof; and the preparation method comprises the following steps: simultaneously weighting cassava starch, polyvinyl alcohol and crosslinking agent according to a certain proportion, then dissolvingseparately, mixing the raw materials, spreading film, crosslinking, removing impurities and loading drugs to prepare the medical cassava starch composite film. The composite film of the invention haswide sources of raw materials and cheap price; cassava starch and polyvinyl alcohol are crosslinked to prepare the reinforced and toughened starch composite film so that the composite film has good biocompatibility, drug-loading property and degradability and higher wet strength; and the film can be used for the coating of body surface traumas, burns and the like and the used waste material can be fairly rapidly degraded so that the medical cassava starch composite film can be utilized to develop a kind of environmentally protective medical film material and has better development potential.

The invention provides a targeting hybrid nano-system, a preparation method thereof and an application. The targeting hybrid nano-system comprises lipid bilayer nanospheres, amphipathic polymeric nano-particles, targeting polypeptides and/or antibodies and different medicines, wherein the lipid bilayer nanospheres wrap the amphipathic polymeric nano-particles, the targeting polypeptides and/or antibodies are connected on the surfaces of the lipid bilayer nanospheres, and the amphipathic polymeric nano-particles and the lipid bilayer nanospheres wrap the different medicines. The prepared targeting hybrid nano-system has targeting according to tumor microenvironments and has a space structure of 'a large sphere wrapping a small sphere', small nano-particles in the system have penetrating capacity for deep tumor tissues, the targeting hybrid nano-system can simultaneously wrap various different water-soluble medicines, and multi-drug combination treatment targeting tumor tissues is achieved, so that the targeting hybrid nano-system has the advantages of good specificity and drug loaded effect, moderate drug release speed, multi-drug combination and multi-targeted treatment.

The invention discloses a special drug-loading hot-melt pressure-sensitive adhesive, which is prepared from the following components in parts by weight: 20-45 parts of a styrene-isoprene-styrene block copolymer thermoplastic elastomer, 1-5 parts of acrylic resin, 5-20 parts of styrene-butadiene-styrene block copolymer thermoplastic elastomer, 20-35 parts of a tackifier, 10-15 parts of a plasticizer, 5-12 parts of a bacteriostatic agent, 0.01-1 part of an age resister and the balance of anti-oxidant, wherein the tackifier is a mixture formed by mixing polyvinylpyrrolidone and one of petroleum resin, rosin resin, terpene resin, terpene-styrene resin and coumarone-terpene resin, wherein polyvinylpyrrolidone accounts for over 50% of the weight of the tackifier. The special drug-loading hot-melt pressure-sensitive adhesive is lasting in adhesivity, good in weather resistance and heat resistance, good in antibacterial effect, good in drug-loading effect and low in cost.

The present invention relates to the field of medicine preparation, in the concrete, it relates to a show-released fibre preparation of water-soluble anti-cancer medicine for body implantation and its preparation method. It is characterized by that the fibre carrier is oil-soluble biological degradable material. and the medicine is water-soluble anticancer medicine, its medicine content is up to 15-50%.

The invention discloses a preparation method of a mesoporous silicon dioxide nanomaterial with fluorescent imaging and drug loading functions. The preparation method is used for solving the technicalproblem that the conventional preparation method of the fluorescent silicon dioxide nanomaterial is complicated. The method comprises the steps of preparing a mesoporous silicon dioxide nano particleby taking cetyl trimethyl ammonium bromide as a template and ethyl orthosilicate as a silicon source by a sol gel method, taking 3-aminopropyl triethoxy alkyl as an amination modification reagent to form aminated mesoporous silicon dioxide, allowing chloro fluorescein carboxyfluorescein diacetate succinimidyl ester to be in reaction with aminated mesoporous silicon dioxide to form a chloro fluorescein-labeled mesoporous silicon dioxide nano particle. The drug loading and fluorescent imaging functions are achieved by firmly linking a fluorescent dye onto mesoporous silicon dioxide by an amido bond. The method is simple to operate, and a strongly corrosive reagent is not required.

The invention relates to the technical field of materials, and discloses a coated barium sulfate nanoparticle used for bone cement developer. The coated barium sulfate nanoparticle mainly comprises porous barium sulfate nanoparticles coated on the surface of the porous barium sulfate nanoparticles and loaded with hexa (6-iodo-6-deoxy)-[alpha]-Polydopamine (PDA) coatings of cyclodextrin (I-CD) andsilver (Ag) were prepared to prepare barium sulfate nanoparticles. The invention discloses a coating barium sulfate nanoparticle, which is prepared by adding the coating barium sulfate nanoparticle into polymethyl methacrylate bone cement as a developer, and the preparation method and the use thereof show excellent X-ray diffraction characteristics. The preparation method is simple and can be usedas a new type of developer in bone cement because of its developmental properties, antibacterial properties, biocompatibility, mechanical properties and drug loading and release properties.

The invention discloses a cryogel for stopping bleeding and bearing an anti-cancer drug and a preparation method thereof, the preparation method comprises the following steps: a double bond is modified to a biomacromolecule, a polyphenolic compound is grafted onto the biomacromolecule, and the dopamine molecule and the Zn 2 + ion are coordinated to prepare dopamine-modified ZIF -8; and all the components are respectively prepared into aqueous solutions or dispersion solutions, and then under the action of an initiator, through double-bond polymerization, the multifunctional water/blood triggered shape memory cryogel l is formed at low temperature. According to the preparation method, polysaccharide and other biomacromolecules with good biocompatibility and degradation performance are taken as the basis, the process of chemical grafting of double-bond or polyphenol compounds also has the characteristics of low toxicity and no pollution, the used double-bond functionalized biomacromolecules are simple to prepare, the synthesis technology is mature, and the prepared product has good universality.

The invention discloses a micromolecule drug-loaded polymer vesicle as well as a preparation method and application thereof. The micromolecule drug-loaded polymer vesicle is prepared by assembling anamphiphilic block polymer and a micromolecule drug, or assembling and crosslinking the amphiphilic block polymer and a functionalized amphiphilic block polymer, loading the micromolecule drug, and reacting with the targeting monoclonal antibody. The vesicle system provided by the invention has many unique advantages, including small size, simple and controllable preparation, excellent biocompatibility, high in-vivo cycling stability, strong tumor cell specific selectivity, high intracellular drug release speed, remarkable tumor growth inhibition effect and the like. Therefore, the vesicle system is expected to become a simple nano platform integrating multiple functions, and is used for efficiently and specifically delivering vincristine sulfate to multiple myeloma cells in a targeted manner.

The invention relates to a preparation method, product and application of a molybdenum oxide nano material. The preparation method comprises the steps that 1, molybdenyl acetylacetonate is dissolved into a mixed solution of octadecene, oleic acid and hexadecylamine, and the materials are stirred and react at the temperature of 90-150 DEG C to generate a molybdenum oxide nano intermediate; 2, the mixed solution containing the molybdenum oxide nano intermediate in step 1 continues to be subjected to a hydrothermal reaction to obtain the urchin-like hollow molybdenum oxide nano material. The obtained molybdenum oxide nano material can achieve specific toxicity activation on tumor parts for efficient tumor imaging and treatment, and can also be rapidly degraded in normal tissue to ensure goodbiological safety.

The invention relates to a novel thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system and a preparation method. Chitosan serves as a membrane material, beta-cyclodextrin serves as a clathration material, and a composite microsphere is prepared in a reversed phase suspension-chemical crosslinking method. According to the novel thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system, the composite microsphere carries thymalfasin. According to the novel thymalfasin drug delivery system, the obtained composite microsphere performs good protection and controlled-release functions on the thymalfasin, provides feasibility for oral administration medicines and has good economic benefits and application prospect.

The invention provides a method for preparing mesoporous silica nanoparticles with a coumarin optically controlled molecular switch by thiol-ene click chemistry. The method comprises the following steps: a coumarin derivative whose side chain contains a double bond is dissolved in a certain solvent, siloxane containing a mercapto group is added, a reaction is carried out in a proper condition with initiation of light or a free radical generating agent, and a silanization reagent containing a coumarin ring structure is prepared. The silanization reagent is grafted to mesoporous silica nanoparticles, and the mesoporous silica nanoparticles with the coumarin optically controlled molecular switch are obtained. The mesoporous silica nanoparticles with the coumarin optically controlled molecular switch are used for controlled release of medicaments.

The invention relates to the field of medical supplies, and particularly relates to a manufacturing method of water-soluble bamboo-fiber hemostatic gauze. The method comprises five procedures of pretreatment, an alkali reaction, an ether reaction, washing treatment and post treatment. The manufacturing method is a method for producing hemostatic gauze, which is simple in production process, relatively few in the kinds of used raw materials and reagents, and further better in effects, particularly in degradation effects.