Albumin-binding indocyanine green anti-tumor photo-thermal preparation and preparation method thereof

A technology of indocyanine green and albumin, which is applied in the field of medicine, can solve the problems of complicated preparation method, unpredictable toxicity in vivo, etc., and achieves the effects of simple preparation method, good druggability, and favorable storage.

Active Publication Date: 2020-05-12
SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Albumin-coated ICG nanoparticles need to change the structure and biological properties of albumin through chemical reactions, the resulting in vivo toxicity is unpredictable, and the preparation method is cumbersome (Zonghai Sheng, Dehong Hu, Mingbin Zheng, Pengfei Zhao, Huilong Liu, Duyang Gao, Ping Gong, Guanhui Gao, Pengfei Zhang, Yifan Ma, and Lintao Cai. ACS Nano. 2014 Dec 23;8(12):12310-22)
[0005] In summary, there is no new dosage form product of ICG that overcomes the above-mentioned defects on the market. Therefore, it is urgent to find a drug with high efficiency, low toxicity, good drug stability, low production cost, simple preparation method and suitable for large-scale industrial production and clinical use. new formulation

Method used

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  • Albumin-binding indocyanine green anti-tumor photo-thermal preparation and preparation method thereof
  • Albumin-binding indocyanine green anti-tumor photo-thermal preparation and preparation method thereof
  • Albumin-binding indocyanine green anti-tumor photo-thermal preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Take 300 mg of human serum albumin and add 10 mL of water for injection to dissolve it to obtain a human serum albumin solution. Dissolve 10 mg of ICG and 10 mg of Solutol HS15 in an appropriate amount of methanol, and remove the methanol by rotary evaporation at 50°C. Add human serum albumin solution, sonicate in water bath for 10 min to form a clear and transparent solution, filter and sterilize to obtain ICG albumin conjugate preparation. The ICG albumin conjugate freeze-dried powder is obtained by freeze-drying under aseptic conditions.

Embodiment 2

[0046] Take 300 mg of human serum albumin and add 10 mL of water for injection to dissolve it to obtain a human serum albumin solution. Take 20 mg of ICG and 200 mg of Solutol HS15 and dissolve them in an appropriate amount of methanol, add 20 mg of glucose, and remove the methanol by rotary evaporation at 50°C. Add human serum albumin solution, sonicate in water bath for 10 min to form a clear and transparent solution, filter and sterilize to obtain ICG albumin conjugate preparation. The ICG albumin conjugate freeze-dried powder is obtained by freeze-drying under aseptic conditions.

Embodiment 3

[0048] Take 200 mg of human serum albumin and add 10 mL of water for injection to dissolve it to obtain a human serum albumin solution. Dissolve 20 mg of ICG and 200 mg of F68 in an appropriate amount of methanol, and remove the methanol by rotary evaporation at 70°C. Add human serum albumin solution, sonicate in water bath for 10 min to form a clear and transparent solution, filter and sterilize to obtain ICG albumin conjugate preparation. The ICG albumin conjugate freeze-dried powder is obtained by freeze-drying under aseptic conditions.

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Abstract

The invention provides an indocyanine green albumin conjugate preparation and a preparation method thereof. An injection mainly contains indocyanine green, albumin and a surfactant. The preparation prepared by the method has tumor targeting, significantly improves drug efficacy and reduces toxicity, and has good biocompatibility, and good stability; and a preparation process is simple, and suitable for industrialized mass production, and has broad application prospects.

Description

technical field [0001] The invention relates to a highly stable albumin-binding indocyanine green anti-tumor photothermal preparation and a preparation method thereof, which can be widely used in industrial production, and belongs to the technical field of medicine. Background technique [0002] Photothermal therapy, by injecting or implanting a photothermal agent at the tumor site, and irradiating the area with a laser of a specific wavelength, the photothermal agent is excited to convert light energy into heat energy quickly, so that the temperature of the tumor site is raised and maintained for a period of time, so as to To achieve the purpose of killing tumor cells. Due to the low absorption and scattering of skin, tissue, blood and water in the near-infrared light region and the development of near-infrared thermal agents, photothermal therapy with near-infrared light with a wavelength of 700-950 nm has become the focus of photothermal therapy. In the past few decades,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/64A61P35/00
CPCA61K41/0052A61K47/643A61P35/00
Inventor 龚涛宋旭赵娟谭田田陈丹张志荣孙逊
Owner SICHUAN UNIV
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