109results about How to "Suitable for large industrial production" patented technology

The invention relates to a multifunctional particle used for stopping human body wounds bleeding, filling, absorbing fluid, preventing adhesion and inducing tissue regeneration and repair. The absorbable particle with multiple functions of stopping bleeding, filling, absorbing the fluid, preventing the adhesion and inducing the tissue regeneration and repair comprises the following raw materials in weight percentage: 30-98.95 percent of polyanionic substance, 1-70 percent of cationic substance and/or polycationic substance, 0.05-2 percent of hyaluronic acid and/or functional factor polypeptide and 0-68.95 percent of pharmaceutical excipient. The particle is 0.01-1.0mm in particle size, and the particle is irregular in shape. The absorbable particle material with the multiple functions of stopping bleeding, filling, absorbing the fluid, preventing the adhesion and inducing the tissue regeneration and repair can be used for stopping the human body wounds bleeding, filling, absorbing fluid, preventing the adhesion and inducing the tissue regeneration and repair and is especially suitable for the wounds and defective tissues during minimally invasive surgery.

The invention discloses a continuous extraction method for pectin, tannin and pigment in a persimmon pericarp, which comprises the following steps: a. after the persimmon pericarp is pretreated, the pretreated persimmon pericarp is extracted by water at a temperature which is more than or equal to 70 DEG C and is less than 100 DEG C to obtain an extract and pulp stock; b. the extract is filtered by an ultrafiltration membrane with a cutoff molecular weight of between 10000 and 30000, the trapped part is a pectin liquid, a filtrate is absorbed and separated by a macroporous resin to obtain the tannin; and c. the pulp stock obtained in step a is extracted by acetone at a temperature of between 60 and 70 DEG C, and an extraction liquid is filtered, distilled and dried to obtain the pigment. The method has rich sources of raw materials, is simple, and is more suitable for large-scale industrial production; a used reagent has lower price, small toxicity, and strong maneuverability, and is easy to amplify the technology, and the cost is lower than extraction cost of corresponding products at present. A product extracted by the method is safe and nontoxic, and has simple and reasonable production technology.

The invention relates to a method for manufacturing a seamless steel pipe of a large-aperture high pressure cylinder for producing a trailer and belongs to the field of manufacturing a seamless steel pipe. The invention mainly solves the technical problem of satisfying the physical dimension precision and the quality requirements on internal and external surfaces of the seamless steel pipe of the large-aperture high pressure cylinder for the trailer at low cost. The invention adopts the technical proposal that after being perforated, a heavy-section round wave steel ingot is formed by being rolled by a step rolled mill and then drawn by a drawing aperture enlarging machine set; the tolerance of the wall thickness of a pipe blank rolled by the step rolled mill is S-8<10> percent and the extreme deviation is less than or equal to 2.5 mm; when the drawing pipe expander set is expanded and manufactured, the aperture enlargement ratio is controlled to be less than 25 percent when the pipe blank is heated each time; the aperture enlargement and the wall reduction are conducted for at most 4 times; the aperture enlargement magnitude of each time is not larger than 45 mm; and the expanding and manufacturing temperature is larger than 780 DEG C at the last expanding and manufacturing.

The invention relates to a high-purity sodium rabeprazole compound, belonging to the technical field of medicine. The method includes the following steps: dissolving crude sodium rabeprazole synthesized by the reaction of rabeprazole and sodium hydroxide in water, adjusting pH value to be faintly acid to neutral by using solid acid salt, and collecting precipitated solid; after dissolving the solid with organic solvent, conducting elution and purification by using eluting agent through macroporous adsorption resin, and collecting eluent; and adjusting the pH value of the eluent to be alkaline, and collecting the precipitated solid to obtain the pure sodium rabeprazole.

The present invention relates to a preparation method of X-ray contrast agent ioversol. The method adopts 5-chloroacetamino-N,N'-bis(2,3- dihydroxypropyl)-2,4,6-triodo-1,3-phthalamine and chloroethanol to make them implement alkylation reaction in the presence of inorganic alkali to obtain reaction liquor, said reaction liquor has no need of separation, and the anhydrous sodium acetate can be directly added to make reaction.

A heat pressing method for polyethylene plant fiber composite material relates to a method for manufacturing plant fiber material. The invention solves the problems that only fibril can be applied, plant format is narrower, straw is liable to thermolysis and charring and the mechanical properties of plant manufactured by pre-heat pressing are poor in the production of WPC in the manner of extraction. The method of the invention has the steps that: PE plastic fiber is mixed with crushed plant aggregates to obtain mixture that is paved into a plate base; the plate base is pre heated under a pressure of 1 to 3 MPa and at a temperature of 170 to 190 CEG D; the plate base is kept under a pressure of 4 to 6 MPa for 8 to 15mins; and at last, the plate base is cooled to 70 to 80 CEG D under a pressure of 3 to 6 MPa; and after pressure relief, the plank is obtained. The flexural strength of the plank manufactured in the method of the invention is 20 MPa. The invention adopts the polyethylene in fiber configuration and the crushed aggregates of the plant and the fiber is evenly mixed and has high productivity. In addition, the crushed aggregates of the plant and the fiber can be prevented from being deteriorated and darkened due to high temperature.

The invention discloses a method for preparing metal nickel nano wires, which comprises the following steps: firstly, dissolving a metal nickel salt and polyvinylpyrrolidone into ethylene glycol according to the mass ratio of 1:0.5-1:20; secondly, adding hydrazine hydrate and 5-15 ml ethanol according to the fact that the mol ratio of the hydrazine hydrate to the metal nickel salt is 0.3-1.9:1; and thirdly, performing heating reaction for 3 to 48 hours until black deposit is generated in a solution, washing and drying the black deposit, and obtaining the black powder metal nickel nano wires, wherein the metal nickel salt is any one of nickel acetate, nickel sulfate, nickel chlorite and nickel nitrate, and the molar concentration of the metal nickel salt in the ethylene glycol is between 0.001 and 0.1 mol/L. The prepared metal nickel nano wires are continuous and compact and have good crystal formation and higher slenderness ratio.

The invention relates to a method for extracting taxol simply, conveniently and efficiently and belongs to a method for extracting taxol. The method comprises: crushing a taxus chinensis dry medicinal material into coarse powder, removing fat soluble impurities by a supercritical CO2 extraction process, and adding cellulase into medicinal residue for hydrolysis; and filtering, drying the medicinal residue, leaching in ethanol, filtering, recovering ethanol under reduced pressure till the residue gives off no alcohol smell, washing the residual with water, discarding washing solution, drying and obtaining taxol by chromatography. The method improves the extraction rate of taxol, uses a small volume of water, avoids using an organic solvent in a solvent extraction method, reduces column loading pressure and is more suitable for mass industrial production.

The invention provides a tumor dual target liposome mediated by integrin and a preparation method thereof. The composition of the invention comprises the components of an antitumor medicament, polypeptide with tumor new vessel target function and tumor cell target function, polyethylene glycol and derivates thereof and a vector for preparing liposome medicaments.

A preparing method of moxifloxacin or slat thereof includes that: 1-cyclopropyl-6,7-difluoro-8-methoxyl-4-oxo-1,4-dihydro-3-quinoline carboxylic acid ester and S,2-2,8-diazabicyclo(4.3.0) nonane are used as raw materials, catalysts are added into the raw materials for condensation reaction in mild condition, and before separation, condensation product moxifloxacin ester can be directly added with hydrolysis of ester group for separation to obtain moxifloxacin or slat thereof. By adopting the method, product purity is high, yield is high, the process is simple and can be controlled easily, and product manufacture cost is low. The preparing method is suitable for large-scale industrial production.

The invention discloses a method for preparing lyophobic silicon dioxide for VOC (Volatile Organic Compound) adsorption. The method comprises the following steps: (1) mixing nitric acid, deionized water and absolute ethyl alcohol in a container so as to obtain a mixed liquid; (2) mixing a silicon dioxide source, the absolute ethyl alcohol and the deionized water so as to obtain another mixed liquid, adding a composite coupling agent, and uniformly stirring; (3) pouring the solution obtained in the step (2) into the mixed liquid obtained in the step (1), keeping the pH value of the solution within 2-6, and stirring for several hours; (4) sealing the container, and aging for 2 hours; (5) performing suction filtration on gel which is subjected to surface modification and is interchanged with a solvent, washing, and leaving to stand at normal temperature; and (6) drying the washed gel, and performing airflow superfine crushing, thereby obtaining a finished product. By adopting the method for preparing the lyophobic silicon dioxide for VOC adsorption, the lyophobic silicon dioxide is capable of adsorbing different types of VOC molecules, and not only is the environment protected, but also the cost is low.

The invention relates to an omeprazole sodium compound and a method for preparing the same. The method comprises the following steps: dissolving an omeprazole sodium crude product in water, adding solution of a solid acid salt into the mixture, collecting the precipitated solid, dissolving the solid by using an organic solvent, eluting and purifying the mixture by an eluant through macroporous resin, collecting the eluate, adding an alkaline solution into the eluate to regulate the pH value to be alkaline, collecting the precipitated solid, and performing vacuum drying on the solid after washing to obtain the refined product of the omeprazole sodium. The purity of the omeprazole sodium prepared by the method is more than 99.8 percent, thus the purity and the preparation stability of the omeprazole sodium product are greatly improved.

The invention relates to a method for preparing a methanation catalyst by adopting a urea combustion method. The method for preparing the methanation catalyst comprises the following steps: firstly mixing a catalyst active component precursor, an auxiliary M precursor and a catalyst carrier precursor; simultaneously adding a combustion agent and a dispersing agent, carrying out ball grinding for 20-60 minutes by adopting a planet ball grinding mill, and uniformly mixing; then transferring the material which is fully ball-ground and uniformly mixed into a crucible or quartz boat, directly placing the crucible or quartz boat into a constant-temperature muffle furnace at a preset temperature of 300-600 DEG C, and carrying out a combustion reaction for 30-60 minutes, thus obtaining the methanation catalyst. According to the method for preparing the methanation catalyst, aluminium nitrate or pseudo-boehmite is taken as a carrier raw material, nickel nitrate is taken as a main active component raw material, nitrates of other metals are taken as auxiliary raw materials, ethyl alcohol is taken as the dispersing agent, urea is taken as the combustion agent, and the method for preparing the methanation catalyst has the biggest advantages of simple operation process, short preparation time and no waste water discharge, and is especially applicable to industrial mass production.

The invention provides a health care product with a function of protecting alcoholic liver injury. The health care product is prepared from the following traditional Chinese medicines in parts by weight: 3-15 parts of roots of kudzu vines, 3-12 parts of Chinese wolfberries, 3-10 parts of turmeric and 2-6 parts of schisandra chinensis. The health care product with the function of protecting alcoholic liver injury provided by the invention can be used for accelerating ethanolic metabolism and protecting liver injury caused by excessive drinking in an auxiliary manner, further has a certain protective effect on chemical liver injury and can be used for preventing and treating liver injury caused by various reasons. The health care product is a liver protective agent which is quick in effect taking, low in cost and small in side effect. The composition provided by the invention is safe and easily available, can be taken for a long time, and is simple in preparation process and suitable for industrial production on a large scale.

The invention discloses a method for purifying a high-purity N-(2',6'-xylyl)-2-piperidinecarboxamide type local anesthetic. The method comprises the following steps: adding N-(2',6'-xylyl)-2-piperidinecarboxamide type compound bases into a mixed solvent to release most impurities, grinding by using a colloid grinder, filtering, and replacing a small quantity of impurities through using a salifying and emulsifying method to obtain a refined product of which the particle size is smaller than 2 microns. The method is simple to operate and good in repeatability, the purity of the product reaches 99.98%, the final yield reaches 74%, and the particle size coefficient of the product is smaller than 2 microns, so that the method is suitable for large industrial production, has good economic benefits and can significantly improve the production efficiency.

The present invention relates to a purification method of X-ray non-ionic contrast agent ioversol. Said invention adopts the solvent recrystallization method to make the ioversol crude product undergo the process of recrystallization at twice, and its used recrystallization solvent includes: normal butyl alcohol, 2-methyl cellosolve and isopropanol mixed solvent and 2-methyl cellosolve and normal butyl alcohol mixed solvent. After having being recrystallized the content of the ioversol can be up to above 99.0%.

The invention provides an indocyanine green albumin conjugate preparation and a preparation method thereof. An injection mainly contains indocyanine green, albumin and a surfactant. The preparation prepared by the method has tumor targeting, significantly improves drug efficacy and reduces toxicity, and has good biocompatibility, and good stability; and a preparation process is simple, and suitable for industrialized mass production, and has broad application prospects.

The invention discloses a health product for increasing bone density, which consists of cattle bone meal, chondroitin sulfate and vitamin D3. Preferably, mass percentages of the components of the cattle bone meal, the chondroitin sulfate and the vitamin D3 by weight are: 74 to 75 percent, 24 to 25 percent and 0.1 to 1 percent respectively. The invention also provides a method for preparing the health product. Animal tests prove that after a rat orally takes the health product for three months, the final weight and the added weight of the rate are both higher than those of a basal feed group and a calcium carbonate control group, and the differences are statistically meaningful; the apparent absorption rate of calcium of the health product is higher than that of the calcium carbonate control group; and the dry weight of the thigh bone and the density at the distal end of the thigh bone of the health product group are obviously higher those of the basal feed group and the calcium carbonate control group. The health product of the invention has the advantages of good calcium supplying effect, high absorption rate, obvious increase of the bone density and wide application prospect.

The invention provides cooling equipment used in the metallurgy field. The cooling equipment comprises a machine frame, a conveying belt and a cooling and cleaning assembly. The cooling and cleaning assembly comprises a cleaning tank, the tank is provided with a cleaning device, cooling spraying water pipes and a water drainage pipeline, and windows are arranged on two opposite lateral walls of the tank in the direction of the conveying belt and provided with curtains. A weight sensor is arranged at the bottom of the window at the inlet side of the tank and used for sensing a metallurgy part entering the tank. The cooling spraying water pipes comprise the upper spraying water pipe located on the upper portion of the tank and the lower spraying water pipe located on the lower portion of the tank and are communicated with a cold water tank located on one side of the machine frame respectively. The cooling equipment is good in cooling effect, high in processing efficiency, good in effect and suitable for large industry production, and reduces manpower and material resources.

The invention discloses a technology for preparing boehmite microcrystal powder only through adjusting the pressure, and belongs to the field of ceramic materials. The boehmite microcrystal powder is prepared from industrial alumina trihydrate with large original crystal (D50 = about 13 [mu]m) and low price by using a high-pressure hydrothermal kettle only through adjusting the pressure in the kettle, and products with superior other performances can be prepared from the boehmite microcrystal powder. The technology concretely comprises the following steps: pulpifying the industrial alumina trihydrate with distilled water, pouring the obtained slurry into the high-pressure hydrothermal kettle with a stirring function, stirring and heating the slurry, only adjusting the pressure in the kettle to prepare a boehmite slurry, carrying out air cooling on the obtained slurry to room temperature, carrying out repeated suction filtration and washing with distilled water until the pH value of obtained filtrate is 7, and drying the filtrate to obtain the boehmite microcrystasl powder with small granularity (D50 = about 3.5 [mu]m), uniform distribution and rhombic block-shaped profile.