3 results about "Clevidipine" patented technology

The invention relates to the technical field of new drugs, in particular to a clevidipine butyrate concentrated solution and a preparation method thereof, and the composition contains clevidipine butyrate, a solubilizer, a cosolvent, a pH regulator and water for injection. Injection oil is abandoned, so that the requirements of lipid metabolism defect patients are met; no phospholipid is used in the prescription, safety risks such as hemolysis, immunoreaction and long-term toxicity and stability problems such as oxidative degradation are avoided, after phospholipid is removed, the clevidipine butyrate preparation can tolerate excessive hot-press sterilization, the sterility level guarantee degree is higher, the state of the clevidipine butyrate preparation is converted into a true solution system from a micelle system, and the stability of the clevidipine butyrate preparation is improved. The solubilizer and the cosolvent are combined, so that the solubility of clevidipine butyrate is greatly improved, dichloromethane, chloroform and other organic solvents with large toxic and side effects are not needed, the toxicity of the medicine is reduced, the stimulation to blood vessels is small, and the adverse reaction of the medicine is reduced; and the preparation method is simple and easy to amplify, and production amplification is facilitated by selecting a production process of a common injection.

Injectable Clevidipine emulsion formulations having enhanced stability and clarity for extended periods of time are disclosed. Methods of making the compositions as well as compositions made by the method and methods of treatment using the compositions are also disclosed.