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Clevidipine butyrate emulsion, preparation method thereof and purpose thereof

A technology of clevidipine butyrate and dipine emulsion, which is applied in the direction of pharmaceutical formula, emulsion delivery, medical preparations of non-active ingredients, etc., and can solve problems such as endangering immune function

Inactive Publication Date: 2011-11-02
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, refined soybean oil mainly contains long-chain triglycerides, which are easily phagocytized and deposited by reticuloendothelial cells in liver, spleen, lung and other organs, thus endangering immune function

Method used

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  • Clevidipine butyrate emulsion, preparation method thereof and purpose thereof

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preparation example Construction

[0033] In a preferred embodiment of the present invention, the preparation method further includes an optional final filtration and / or autoclaving step.

[0034] In another aspect, the present invention provides a pharmaceutical composition comprising the above-mentioned clevidipine butyrate. The pharmaceutical composition uses the above-mentioned clevidipine butyrate as an active ingredient, and optionally includes one or more pharmaceutically acceptable excipients and / or carriers. The pharmaceutically acceptable excipients and / or carriers include emulsifiers such as lecithin, polyoxyethylene castor oil; pH regulators such as phosphate buffer, borate buffer, etc.; bacteriostatic agents such as paraben Class (parabens), benzyl alcohol, sodium benzoate, etc.; co-solvents such as Tween-80, propylene glycol, etc.

[0035] In yet another aspect, the present invention also provides ophthalmic preparations comprising the clevidipine butyrate, preferred dosage forms include eye drop...

Embodiment 1

[0043] Example 1 : Clevidipine Butyrate Emulsion

[0044] 0.01-20% clevidipine butyrate

[0045] 10-25% lipid phase

[0046] Emulsifier accounting for 0.1-1.5 times the weight of lipid phase

[0047] 40-99% water or buffer.

Embodiment 2

[0048] Embodiment 2: Clevidipine butyrate emulsion

[0049] Clevidipine Butyrate 0.7g

[0050] Medium Chain Triglycerides 180g

[0051] Egg yolk lecithin 15g

[0052] Glycerin 25g

[0053] Appropriate amount of sodium hydroxide

[0054] Add water for injection to 1000ml

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Abstract

The invention relates to a therapeutic emulsion of clevidipine butyrate. The emulsion comprises clevidipine butyrate, a lipid phase, an emulsifier, and water or a buffer. The invention also relates to a purpose and a preparation method of the emulsion.

Description

technical field [0001] The invention relates to an emulsion of clevidipine butyrate, especially an emulsion for intravenous injection, and also provides a method for preparing the emulsion. In addition, the present invention also relates to the use of the emulsion in the preparation of medicines for treating hypertension (especially for patients who are not suitable for treatment with oral antihypertensive drugs). Background technique [0002] Adjustable blood pressure control is of great importance in many serious clinical situations, such as in most patients undergoing cardiac, brain, orthopedic or fibrosurgery. In these cases, it is often of paramount importance to quickly and safely lower blood pressure to a predetermined level, maintain it for a predetermined period of time, and then return it quickly to normal. The most important thing in this situation is to minimize the administration volume given to the patient, so it is important to administer a concentrated pharm...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/4422A61K47/24A61P9/12
Inventor 王凌蒋学华
Owner SICHUAN UNIV
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