Pharmaceutical composition with short pressure-reducing function

A composition and drug technology, applied in the directions of drug combination, non-active ingredient medical preparations, medical preparations containing active ingredients, etc., can solve the problems of not considering the risk of lipid peroxidation, short-acting antihypertensive effect, etc. , to achieve less hypertriglyceridemia, improve damage, reduce liver load

Inactive Publication Date: 2010-08-04
广州中大创新药物研究与开发中心有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the existing short-acting antihypertensive drug compositions for intravenous injection do not take this risk of lipid peroxidation into consideration

Method used

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  • Pharmaceutical composition with short pressure-reducing function
  • Pharmaceutical composition with short pressure-reducing function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Prepare the pharmaceutical composition of the present invention according to the following formula:

[0038] Clevidipine Butyrate 0.50g

[0039] soybean oil 100g

[0040] Medium Chain Triglycerides 100g

[0041] α-Tocopherol 1.0g

[0042] Lecithin 12g

[0043] Glycerin 22.5g

[0044] Add water for injection to 1,000ml

[0045] The average particle size of the prepared emulsion was 205 nm. The emulsion was stored in the dark at 25°C for 2 months, and the appearance did not change significantly.

Embodiment 2

[0047] Prepare the pharmaceutical composition of the present invention according to the following formula:

[0048] Clevidipine Butyrate 0.50g

[0049] soybean oil 200g

[0050] α-Tocopherol 1.0g

[0051] Lecithin 12g

[0052] Glycerin 22.5g

[0053] Add water for injection to 1,000ml

[0054] The average particle size of the prepared emulsion was 197 nm. The emulsion was stored in the dark at 25°C for 2 months, and the appearance did not change significantly.

Embodiment 3

[0056] Prepare the pharmaceutical composition of the present invention according to the following formula:

[0057] Clevidipine Butyrate 0.50g

[0058] soybean oil 100g

[0059] Medium Chain Triglycerides 100g

[0060] α-Tocopherol 1.0g

[0061] Lecithin 12g

[0062] Glycerin 22.5g

[0063] Add water for injection to 1,000ml

[0064] The average particle size of the prepared emulsion was 198 nm. The emulsion was stored in the dark at 25°C for 2 months, and there was no obvious change in appearance.

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Abstract

The invention discloses a pharmaceutical composition with short pressure-reducing function and a preparation method of emulsion injection thereof. The pharmaceutical composition comprise: 1) dihydropyridine medicine clevidipine butyrate with the function of reducing pressure in short period; 2) alpha-DL-vitamin E; 3) one or more kinds of injection oil; 4) one or more kinds of emulsifying agents; 5) injection water or buffer solution. The pharmaceutical composition not only can reduce blood pressure but also can improve damage to tissue and organs of the user caused by lipid peroxidation, thereby obviously reducing load of liver and reducing incidence rate of hypertriglyceridemia.

Description

technical field [0001] The present invention relates to a kind of pharmaceutical composition with short-acting antihypertensive effect and preparation method thereof emulsion injection; More specifically, the present invention relates to a kind of medicine with clevidipine butyrate and α-vitamin E as main components Compositions and methods for their preparation. The invention also relates to the advantages of the emulsion in reducing the risk of lipid peroxidation in hypertensive patients and helping to increase the stability of clevidipine butyrate during treatment. Background technique [0002] In recent years, the number of hypertensive patients during surgical operations has gradually increased, and the blood pressure regulation of perioperative hypertensive patients has become a common clinical problem. For critically ill patients in the perioperative period, the strategy of antihypertensive treatment is to reduce blood pressure while improving the pathophysiological ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K31/355A61K36/815A61K47/14A61K9/107A61P9/12A61P39/06
Inventor 汤毅张霖泽高越岳峰
Owner 广州中大创新药物研究与开发中心有限公司
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