36 results about "Ioversol" patented technology

The invention relates to multifunctional gold and silver core-shell nanoparticles. The gold nanopartciles are covered by silver nano shell layers and the nanoparticles with silver core shell structures are conducted for surface modification through sulfydryl polyethylene glycol molecules; and gold nano core particles are 3 to 20 nm in size, and silver nano shells are 2 to 12 nm in size. Especially, the gold and silver core-shell nanoparticles covered by the silver nano core and shells are prepared by reducing chloroauric acid to prepare ultrafine fold nanopartciles through tetrakisphosphonium chloride activated by alkaline liquor as a reducing agent, and reducing a silver nitrate solution by nanoparticles as crystal nucleuses; and a CT (Computed Tomography) contrast medium with long-efficiency blood circulation time and an anti-infective function is obtained by performing surface modification for the gold and silver core-shell nanoparticles through polyethylene glycol modified by tail sulfhydrylation. The multifunctional gold and silver core-shell nanoparticles are uniform in particle size, good in water solubility, and free from obvious agglomeration, and the core-shell nanoparticles have stronger dissipation capacities on X rays, thereby being superior to effective developing time of CT of traditional contrast medium ioversol; and the core-shell nanoparticles effectively inhibit infection of bacteria through a contrast medium injection window.

The present invention relates to a contrast medium composition (formulation) comprising a highly concentrated contrast agent for use in an imaging method. The contrast medium composition comprises an aqueous contrast agent selected from the group consisting of iopentol, iotrolan, iohexol, ioversol, ioxilan, iodixanol and iobitridol in an amount of 360 mgl / mL to 450 mgI / mL. The contrast medium composition according to the present invention, which comprises iodine working as a contrast agent in a higher concentration than the concentration used before, shows higher contrast enhancement effect in both of arterial phase and portal phase when used for liver CT than a composition comprising the contrast medium in a concentration used before. Accordingly, images having excellent resolution and discrimination can be obtained.

The invention relates to a method for purifying ioversol that is x-ray nonionic contrast agent. The method adopts ethanol as recrystallization solvent to recrystallize ioversol crude-product, and the content of the obtained ioversol pure-product is more than 98.5 percent. The method is simple, easy to operate, economical and practical, and suitable for large-scale industrial production.

The invention discloses a preparation method of X-ray contrast agent ioversol intermediate, belonging to the technical field of organic compound preparation. The chemical name of the intermediate is 5-chloroacetamide-N,N'-bi(2,3-dyhydroxyl propyl)-2,4,6-triiodo-1,3-benzenedicarboxamide. The method utilizes 5-amino-2,4,6-triiodo-1,3-phthalic acid to react with thionyl chloride, and then reacts withchloroacetic chloride to obtain 5-chloroacetamide-2,4,6-triiodo-1,3-benzenedicarbonyl dichloride, finally reacts with 3- amino-1,2- propylene glycol to obtain the 5-chloroacetamide-N,N'-bi(2,3-dyhydroxyl propyl)-2,4,6-triiodo-1,3-benzenedicarboxamide. The method has simple synthesis process route, shortened reaction steps, mild reaction condition, security and reliability, stable quality, high yield, low cost and less equipment investment, thereby being applicable to large-scale industrial production.

The present invention relates to a preparation method of X-ray contrast agent ioversol. The method adopts 5-chloroacetamino-N,N'-bis(2,3- dihydroxypropyl)-2,4,6-triodo-1,3-phthalamine and chloroethanol to make them implement alkylation reaction in the presence of inorganic alkali to obtain reaction liquor, said reaction liquor has no need of separation, and the anhydrous sodium acetate can be directly added to make reaction.

The invention discloses a method for preparing ioversol. Compound I: [5-hydroxyacetamido]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo ‑1,3‑phthalamide, chloroethanol or its analogues are used as raw materials, and disodium hydrogen phosphate or dipotassium hydrogen phosphate is used as an acid application agent, reacted in a solvent, and after the reaction is completed, ioversol is obtained through post-treatment. By buffering alkali disodium hydrogen phosphate or dipotassium hydrogen phosphate as an acid-binding agent, the reaction conditions are relatively mild, which overcomes the shortcoming of unstable pH in the reaction process, so the present invention prepares ioversol with few and small impurities, especially alkoxy Basic impurities can be controlled below 0.5%, the yield is high, up to 90-98%, green and environmentally friendly, and the operation is simple.

The invention provides a preparation method for ioversol. Specifically speaking, the method comprises the following steps: (1) performing an alkylation reaction on 5-chloracetyl amino-N,N'-bi-(2,3- dyhydroxyl propyl)-2,4,6-triiodo-1,3-phthalic diamide and chlorethyl alcohol under an alkaline condition; (2) hydrolyzing through sodium acetate to obtain the ioversol. A container of which the inner wall is coated with a corrosion-resistant coating is used in the reactions of the former two steps, and the water with the iron content of below 0.05 ppm is used. The method can effectively avoid the production of impurities which are difficult to remove, and is suitable for industrial production.

The invention discloses a method for purifying a contrast agent ioversol, which comprises the following steps: purifying an ioversol crude product solution through a macroporous adsorption resin packed column to obtain an ioversol pure product. The high-quality pure ioversol product is obtained by using the purification method, and the purity of the high-quality pure ioversol product is as high as 99.220%-99.619% and even higher than that of a reference preparation. In addition, the purification method disclosed by the invention is carried out at room temperature, and is low in cost, high in yield, easy in solvent recovery, large in batch, short in period, highly automatic in process, environment-friendly and pollution-free, easy in production process amplification and capable of realizing large-scale industrial production.

The invention provides a preparation method of ioversol. Particularly, the method provided by the invention comprises the following steps: carrying out alkylation reaction on 5-chloracetylamino-N,N'-bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-phenyldiformamide and chloroethanol by using sodium hydroxide / sodium borate or sodium hydroxide / lithium chloride; and meanwhile, directly hydrolyzing the product by a one-pot multistep process, and carrying out desalting and purification to prepare the ioversol. The method simplifies the production technique process, effectively controls the generation of irremovable impurities, and is suitable for industrial production.

The invention discloses a preparation method of traceable polylactic acid / rifampicin drug-loaded microspheres, which comprises the following steps: dissolving polylactic acid in dichloromethane, then adding span-80 and rifampicin, and carrying out ultrasonic emulsification to obtain an emulsion; pouring the emulsion into a PVA (Polyvinyl Alcohol) aqueous solution, and shearing and dispersing to obtain an oil-in-water emulsion; stirring the oil-in-water emulsion , adding an ioversol contrast agent solution dropwise, then adding sodium tripolyphosphate dropwise , and curing and forming microspheres to obtain polylactic acid two-layer composite drug loading ; putting the microspheres into a dichloromethane solution dissolved with polylactic acid to obtain three-layer composite drug-loaded microspheres, adding the three-layer composite drug-loaded microspheres into an ioversol contrast agent solution, and dropwise adding TPP to obtain a solution; and centrifuging the obtained solution, and taking out the microspheres at the bottom. The preparation process of the drug-loaded microspheres is simple and rapid, the product has a tracing function, high drug loading rate and encapsulation efficiency and long slow release time, polylactic acid with good biodegradability is used in the preparation process, and the drug-loaded microspheres have wide application prospects.

The invention discloses a preparation method of X-ray contrast agent ioversol intermediate, belonging to the technical field of organic compound preparation. The chemical name of the intermediate is 5-chloroacetamide-N,N'-bi(2,3-dyhydroxyl propyl)-2,4,6-triiodo-1,3-benzenedicarboxamide. The method utilizes 5-amino-2,4,6-triiodo-1,3-phthalic acid to react with thionyl chloride, and then reacts with chloroacetic chloride to obtain 5-chloroacetamide-2,4,6-triiodo-1,3-benzenedicarbonyl dichloride, finally reacts with 3- amino-1,2- propylene glycol to obtain the 5-chloroacetamide-N,N'-bi(2,3-dyhydroxyl propyl)-2,4,6-triiodo-1,3-benzenedicarboxamide. The method has simple synthesis process route, shortened reaction steps, mild reaction condition, security and reliability, stable quality, high yield, low cost and less equipment investment, thereby being applicable to large-scale industrial production.

The present disclosure generally relates to a new process for the preparation of high purity 5-nitro-isophthalamide compounds, which are useful as intermediates for the preparation of imaging agents, such as iodinated x-ray contrast imaging agents like ioversol, iohexyl and iopamidol.

The invention relates to a method for purifying ioversol that is x-ray nonionic contrast agent. The method adopts ethanol as recrystallization solvent to recrystallize ioversol crude-product, and the content of the obtained ioversol pure-product is more than 98.5 percent. The method is simple, easy to operate, economical and practical, and suitable for large-scale industrial production.

A method for purifying ioversol, the invention relates to a method for purifying ioversol as an x-ray non-ionic contrast agent. The method adopts the solvent recrystallization method to carry out two recrystallizations to the ioversol crude product, and the recrystallization solvent used includes: n-butanol, 2-methoxyethanol and isopropanol mixed solvent, 2-methoxyethanol and n-butanol Solvents are mixed, and the content of ioversol reaches more than 99.0% after recrystallization. The method is economical and practical, easy to operate and suitable for industrial production.