3 results about "Ioversol" patented technology

The utility model provides an ioversol purifying device which comprises a supporting frame, a settling tank, a solvent tank and an air compressor are arranged in the supporting frame, the lower end of the settling tank is arranged in a necking mode and is in threaded connection with a storage pipe, an air outlet is formed in one side of the upper portion of the settling tank, an air inlet is formed in the upper end of the solvent tank, and an air outlet is formed in one side of the lower portion of the solvent tank. The input end of the air compressor is connected with an air outlet pipeline, and the output end of the air compressor is connected with an air inlet pipeline. According to the present invention, the solvent is evaporated through the negative pressure form so as to achieve the crystallization precipitation of the ioversol, and the quality of the purified ioversol can be improved at the low temperature.

This invention relates to a method for removing the impurity 5-hydroxyacetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-phenylenediamide (compound of formula 1) from the X-ray contrast agent iodofol, with the structural formula: The method utilizes a strongly basic anion exchange resin to selectively adsorb this impurity, achieving excellent results and contributing to the improvement of the purity and yield of iodofol.

This invention discloses an improved reservoir-type vaginal ring. The drug is loaded as a drug-carrying core by mixing it with silicone rubber, and the core is coated with a controlled-release layer made of pure silicone rubber. The drug-carrying core contains a developing agent and a dispersant. The developing agent includes barium sulfate, titanium dioxide, iodotram, iodofol, iopromide, iodophenylhexamol, and iodophenyl ester. The dispersant includes methyl silicone oil, phenyl silicone oil, vinyl silicone oil, hydrogen-containing silicone oil, and glycerin. This invention combines the advantages of existing extrusion and molding methods, effectively controlling the size and regularity of the drug-carrying core of the reservoir-type vaginal ring, ensuring stable and controllable drug content. It can effectively improve the product deformation problems caused by cutting, external force, and hot-pressing vulcanization processes in existing co-extrusion processes.