Completely-biodegradable support capable of developing and preparation method thereof

Abstract

The invention relates to the field of medical apparatuses and instruments and provides a completely-biodegradable support capable of developing and a preparation method thereof. A connecting rod of a support main body is provided with holes, markers which can develop in X-rays are filled in the holes, and each marker is composed of an outer protective layer, a developing layer and an inner protective layer. Both the support main body and the protective layers are made of biodegradable materials such as poly L lactic acid (PLLA), polycaprolactone (PCL) and poly lactic-co-glycolic acid (PLGA); the developing layers are made of contrast agents used for human bodies, and one or more than two of preferential amidotrizoic acid, diatrizoate, iohexol, iopromide and ioversol; and crystallization is carried out in advance through purification. The completely-biodegradable support can be clearly seen in the X-rays, the markers can be controlled to be completely degraded in 6 months to 2 years, developing time can be long, accordance can be achieved, and needs for support developing can be fundamentally met.

Description

technical field [0001] The invention relates to a medical device, in particular to a fully degradable polymer bracket that can be developed and a preparation method thereof. Background technique [0002] Traditionally used stents for the treatment of vascular stenosis are all made of metal materials, which can be clearly seen under X-rays, but because the materials cannot be degraded and absorbed by the human body, they will permanently stay in the human body after implantation, like a metal "vest". "It also restricts the normal contraction and pulsation of blood vessels, and in severe cases, it will cause late thrombosis of the stent and cause the death of the patient. Furthermore, the existence of metal implants will affect the subsequent MRI or CT images of blood vessels and interfere with the doctor's judgment. [0003] In view of the existence of such problems, degradable stents that can be degraded and absorbed by the human body have emerged as the times require. Aft...

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Problems solved by technology

However, this method also has its disadvantages: the bonding strength with the main body of the stent is weak, and it is easy to fall off during the subsequent stent crimping and opening, resulting in poor developing effect; secondly, the dipping / spraying of the stent takes a long time to dry. Remove the solvent; moreover, the developer layer coated on the outer layer of the stent will disappear prematurely with the degradation of the material, which will cause inconvenience to the late follow-up of the stent

[0006] In view of the problems of poor biocompatibility and possible side effects of indwelling metal developers in the prior art; and the complex preparation of the developing coating, the coating is easy to fall off, cracks and other instability problems during the preparation and implantation process, further research is needed Exploring stable and biocompatible X-ray opaque stents

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