Composite developing thermosensitive gel embolizing agent as well as preparation method and application thereof

A technology of sensitive gel embolic agent and temperature-sensitive gel agent, which is applied in the field of composite temperature-sensitive gel matrix, can solve problems such as inability to continuously exert embolism function, incomplete embolization effect, and unstable temperature-sensitive gel, and achieve the goal of being suitable for large-scale production and overcoming Unstability, chance reduction effects

Active Publication Date: 2017-10-24
苏州申润医疗科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A single temperature-sensitive gel has the disadvantage of being unstable. It will undergo obvious erosion in the solution until the structure dissociates, and cannot continue to perform the embolization function, resulting in an incomplete embolization effect.

Method used

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  • Composite developing thermosensitive gel embolizing agent as well as preparation method and application thereof
  • Composite developing thermosensitive gel embolizing agent as well as preparation method and application thereof
  • Composite developing thermosensitive gel embolizing agent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Preparation and Characterization of Composite Developing Thermosensitive Gel with Different Components

[0042] Take 5000mg of hydroxymethylcellulose and add 100ml of iodixanol solution with a concentration of 20mg I / L, avoid light, stir at room temperature for 24h, stir well, then add 5000mg of sodium alginate and 1mg of arsenic trioxide, and continue stirring at room temperature for 24h , stir well. In the above solution, add F127 so that the concentration of F127 is 5%, and dissolve it in the dark under an ice bath at 0°C to obtain a composite thermosensitive gel of iodixanol, sodium alginate, hydroxy C1-4 alkyl cellulose, F127 and arsenic trioxide Glue solution, spare.

[0043] Prepare CaCl with a concentration of 5mol / L 2 solution, set aside.

[0044] At room temperature, the composite developing thermosensitive gel was divided into two parts, one part was the composite developing thermosensitive gel, and the other was the composite developing thermosensitive ge...

Embodiment 2

[0047] Preparation of Arsenic Trioxide Composite Imaging Thermosensitive Gel and Its Application in Renal Artery Embolization

[0048] Take 500 mg of hydroxy C1-4 alkyl cellulose and add it to 100 ml of iodixanol solution with a concentration of 200 mg I / L, stir at room temperature in the dark for 24 hours, stir evenly, then add 1 mg of sodium alginate and 1 mg of arsenic trioxide, and keep in the dark at room temperature Stir for 24h, stir evenly. In the above solution, add P105 so that the concentration of P105 is 30%, and dissolve in an ice bath at 0°C in the dark to obtain a composite developing thermosensitive gel solution, which is ready for use. Prepare Ca(CH 3 COO) 2 solution, set aside.

[0049] The prepared composite imaging thermosensitive gel was injected into the normal rabbit renal artery, and the embolization effect was observed. In normal rabbits, the right femoral artery was cannulated to the opening of the left renal artery, and 1ml of composite imaging t...

Embodiment 3

[0051] Preparation of docetaxel composite imaging thermosensitive gel and application of left gastric artery embolization

[0052] Take 1000mg of hydroxy C1-4 alkyl cellulose and add 100ml of iohexol solution with a concentration of 20mg I / L, and stir at room temperature for 24 hours in the dark, and stir evenly, then add 50mg of sodium alginate and 10mg of docetaxel, in the dark Stir at room temperature for 24h, stir evenly. In the above solution, add F127 so that the concentration of F127 is 25%, and dissolve in an ice bath at 0°C in the dark to obtain a composite developing temperature-sensitive gel solution for future use. Prepare CaCl with a concentration of 0.001mol / L 2 solution, set aside.

[0053] The prepared composite imaging thermosensitive gel was injected into the left gastric artery of normal rabbits, and the embolization effect was observed. Intubate the right femoral artery of normal rabbits to the opening of the left gastric artery, inject 1ml of composite ...

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Abstract

The invention relates to a composite developing thermosensitive gel embolizing agent as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, preparing a mixed aqueous solution of an anticancer active substance, a thermosensitive material and a developing agent into composite developing thermosensitive gel; secondly, forming a composite developing thermosensitive gel embolizing agent by the composite developing thermosensitive gel and a coagulant on the scene, wherein the thermosensitive material is hydroxyl C1-4 alkyl cellulose, Pluronic, alginate or a mixture of the substances; the anticancer active substance is arsenic trioxide, docetaxel, cisplatin, carboplatin, nedaplatin, oxaliplatin, lobaplatin, miriplatin, siRNA or a mixture of the substances; the developing agent is a water-soluble developing agent of iodixanol, ioversol or iohexol and the like. The preparation method disclosed by the invention is simple and convenient, is suitable for industrial large-scale production, is particularly suitable for preparing an embolizing agent which is biodegradable and good in biocompatibility and is used for hemorrhagic diseases, and is especially suitable for preparing the composite developing thermosensitive gel embolizing agent for treating liver cancer, kidney cancer, lung cancer, prostate cancer, uterine myoma or splenic tumor and the like.

Description

technical field [0001] The invention belongs to a composite thermosensitive gel matrix, in particular to the application of a composite imaging thermosensitive gel embolic agent in the embolization treatment of liver tumors. Background technique [0002] Transcatheter arterial chemoembolization (TACE) is to inject chemotherapy drugs and embolic agents into diseased blood vessels through the guidance of interventional arterial catheterization. Necrosis and shrinkage in order to control bleeding; on the other hand, increase the local drug concentration and prolong the contact time between drugs and tumor tissues, so as to achieve the purpose of treating tumors and vascular lesions and eliminating the function of diseased organs. Therefore, embolic agents play a key role in arterial perfusion embolization. Currently clinically used embolic agents include liquid embolic agents and granular embolic agents. Although these embolic agents have been continuously developed and impro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/04A61K9/06A61K33/36A61K33/24A61K31/337A61K47/10A61K47/38A61K47/36A61K47/02A61P35/00A61P7/04
CPCA61K9/0024A61K9/06A61K31/337A61K33/24A61K33/36A61K47/02A61K47/34A61K47/36A61K47/38A61K49/0438
Inventor 段友容沈鸣黄莉莉
Owner 苏州申润医疗科技有限公司
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