264 results about "Arsenic trioxide" patented technology

The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.

The present invention provides an oral formulation of arsenic trioxide (As2O3) for the treatment of a variety of hematological malignancies, including acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL). The present invention also provides methods for making the oral arsenic trioxide formulation. Methods of using the oral arsenic trioxide formulation are also described.

The invention discloses a method for extracting high arsenic complicated golden ore concentrate multielement. The method comprises the following steps that: the multielement complicated golden ore concentrate with extra-high arsenic is subjected to the roast dearsenification technique treatment, part of sulfur in the multielement high arsenic golden ore concentrate converted into sulfur dioxide and the arsenic converted into arsenic trioxide enter flue gas which is subjected to dust and arsenic collection, and then enter an acid making system to produce sulphuric acid; the multielement smelting slag and multielement low arsenic golden ore concentrate obtained by roast dearsenification, return products and flux are mixed to obtain copper matte regulus, and the like by adopting oxygen enrichment bottom blowing matte smelting gold collecting process to carry out the smelting process; the copper matte regulus is subjected to converting and refining to cast an anode plate which is sent to an electrolysis system to obtain an electrolytic copper product by refining; anode mud generated through electrolysis is sent to a noble metal refine system to produce gold and sliver, and the like; smelting slag and converting slag are subjected to floatation treatment to obtain copper and iron ore concentrate; and the generated gangue belongs to harmless slag and can be used. The method has the characteristics of wide range of the raw material application, high synthesized recovery efficiency of valuable element, and obvious economic and environment benefits.

An arsenic removal method from smoke dust containing As2O3 is provided, which is suitable for the arsenic removal treatment of smoke dust that exists in form of As2O3, etc. The method is to use sodium hydroxide, sodium carbonate or ammonia to regulate the pH value of leaching solution to be 5-12 and the liquid-solid weight ratio to be 2-10 to 1. Hydrogen peroxide is added for the leaching under the stirring condition. The addition amount of the hydrogen peroxide is 100-300 percent of the chemical reaction measurement. The leaching temperature is 20-100 DEG C. The leaching time is 1-10 hours. The arsenic is dissolved in the solution. And the arsenic removal rate can reach to 80 percent above. The concentration of valuable elements in the solution is low and the most are reserved in slag.

The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.

The invention provides a method for controling arsenic pollution in the copper metallurgy industry, is characterized in that arsenic acid filtering case is added as vulcanized agent in sulphuric acid extract of copper metallurgy smoke to precipitate copper, copper slag and the solution containing copper are obtain by separation; the solution containing copper is contracted to 60-100 g / l of arsenical concentration and then cooled to the room temperature, heptahydrate zinc sulphate and crystal mother liquor are obtained after separation; sulfur dioxide is added to crystal mother liquor, thereby arsenic is dissolved out in the form of arsenic trioxide, arsenic trioxide and the solution after precipitating arsenic are obtained after separation, the solution after precipitating arsenic is back to smoke extract. The separature of the main component such as copper, arsenic, zinc and cadmium is performed in sulphuric acid extract of copper metallurgy smoke and arsenic acid filtering case with an objective for controling arsenic pollution economically and effectively, while provided with an advantage for further recycling valent metal synthetically.

Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.

Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.

The invention provides a method for preparing arsenic trioxide from arsenic sulfide waste. The arsenic sulfide waste is soaked in a sodium hydroxide solution to extract arsenic sulfide, arsenic sulfide mixes with an excessive amount of arsenic acid, and the mixture reacts at a temperature ranging from 40 DEG C to 95 DEG C for 0.5 to 3 hours, to produce a mixture containing arsenous acid and elemental sulfur; the mixture containing arsenous acid and elemental sulfur mixes with 2 to 5 times (by mass) of water and then oxygen gas is introduced so that arsenous acid is oxidized into arsenic acid, and the reaction product is filtered to remove elemental sulfur and thus to produce an arsenic acid solution; and the arsenic acid solution is reduced by sulfur dioxide gas to arsenous acid with a lower solubility, the reaction liquid is distilled under a reduced pressure to produce a saturated solution of arsenous acid, the saturated solution of arsenous acid is cooled so that arsenous acid is crystallized and then filtered to produce a filter cake of arsenous acid, and the filter cake of arsenous acid is dried and pulverized to obtain an arsenic trioxide product. The method has a short process flow, increases the recovery rate of arsenic, avoids the production of secondary pollutants, adopts simple equipment, greatly reduces the cost of arsenic recovery and is worthy to be widely applied.

The invention relates to a method to produce arsenic trioxide with waste water containing arsenium, which takes waste water containing arsenium as raw material to produce arsenic trioxide. A. alkali is added to remove impurities, cupric salt is added, the pH value of the solution is adjusted to 4-14 by alkali and green copper arsenite or copper arsenate precipitate is prepared; B. the prepared green copper arsenite or copper arsenate precipitate is made into slurry by water or sulphuric acid solution; sulfur dioxide is pumped into or sulphite is added to be reacted, arsenious acid solution and pink filtration residue are obtained after filtration; C. arsenious acid solution is crystallized, filtered and dried to get arsenic trioxide powder. The invention has the advantages of simple process, saving raw materials, reducing cost and high recovery yield.

An elution stent with controlled release of As2O3 for preventing and treating coronary heart disease features that the As2O3 is used as the stent medicine and the dual coated layers including the coated butyl polymethylatel nano-SiO2 layer and the coated PLGA layer are used to control the release of As2O3 for inducing the wither of smooth muscle cells at the second stage of damaged blood vessel.

The NSAID, sulindac and / or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.

The invention provides a cascade recovery method for arsenic-containing antimony-containing gold ore difficult to process, and relates to a method for separating and extracting antimony, arsenic and gold of the gold ore difficult to process. The method is characterized in that the recovery process includes the steps that (1) sodium sulphide is added under the alkaline condition, and antimony leaching is carried out; (2) electrodeposition is conducted on leaching liquid to obtain cathode antimony liquid; (3) leaching residues are washed, and concentrated sulfuric acid is added into the washed liquid for antimony deposition; (4) the leaching residues are roasted for arsenic removal and desulfuration, so that pozzuolite enters smoke, the smoke is chilled and crystallized to recover arsenic trioxide, and acid making with smoke is achieved after arsenic recovery; and (5) gold and silver in the roasted residues are separated after antimony, arsenic and sulphur are extracted. The method is special for the arsenic-containing antimony-containing gold ore difficult to process, the influences of arsenic and antimony on the recovery rate of noble metal are effectively eliminated, the problem that arsenic and antimony are difficult to separate is solved through selective leaching, valuable elements such as antimony, arsenic and sulphur are comprehensively recycled, and the recovery rate of gold and silver is also increased. According to the technology, raw material adaptability is high, the technology process is short, and energy consumption is low.

Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.

The invention relates to a composite developing thermosensitive gel embolizing agent as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, preparing a mixed aqueous solution of an anticancer active substance, a thermosensitive material and a developing agent into composite developing thermosensitive gel; secondly, forming a composite developing thermosensitive gel embolizing agent by the composite developing thermosensitive gel and a coagulant on the scene, wherein the thermosensitive material is hydroxyl C1-4 alkyl cellulose, Pluronic, alginate or a mixture of the substances; the anticancer active substance is arsenic trioxide, docetaxel, cisplatin, carboplatin, nedaplatin, oxaliplatin, lobaplatin, miriplatin, siRNA or a mixture of the substances; the developing agent is a water-soluble developing agent of iodixanol, ioversol or iohexol and the like. The preparation method disclosed by the invention is simple and convenient, is suitable for industrial large-scale production, is particularly suitable for preparing an embolizing agent which is biodegradable and good in biocompatibility and is used for hemorrhagic diseases, and is especially suitable for preparing the composite developing thermosensitive gel embolizing agent for treating liver cancer, kidney cancer, lung cancer, prostate cancer, uterine myoma or splenic tumor and the like.

The invention discloses a method for extracting arsenic trioxide from gold concentrate powder roasted fume containing arsenic. The method adopts a staged gradually-heating purification process and a quenching extraction process. The purification process is to volatilize impurities with low melting points in materials under the condition of different temperatures. The purified materials are insulated at a temperature of between 500 and 550 DEG C for more than 150 minutes, so that the arsenic is oxidized into arsenic trioxide gas; the gas is purified through a cyclone dust collector and an electrostatic precipitator in sequence; the purified high-temperature arsenic trioxide gas directly enters a quenching tower of which the temperature is between 120 and 140 DEG C to be crystallized into arsenic trioxide microparticles; and powdery arsenic trioxide collected by a bag arsenic collector is outputted via a scraper conveyor. The method has the advantages that the process procedure is arranged reasonably, controllably and stably, and the rate of extracting the arsenic trioxide from fume is high, and the purity of the extracted arsenic product is high, and the method well solves the problem of arsenic pollution in the gold smelting industry.

The invention relates to a glass for sealing with metal or alloy, wherein the mol ratio of its constituents being, 70.0% to 80.0% of silicon oxide, 0.0% to 4.0% of aluminium oxide, 12.0% to 19.0% of boron oxide, 0.0% to 4.0% of lithium oxide, 0.0% to 6.0% of sodium oxide, 0.0% to 8.0% of potassium oxide, 0.0% to 6.0% of magnesium oxide, 0.0% to 6.0% of calcium oxide, 0.0% to 6.0% of strontium oxide, 0.0% to 6.0% of barium oxide, 0.0% to 6.0% of zinc oxide, 0.0% to 6.0% of arsenic trioxide, 0.0% to 1.0% of cerium oxide. The glass has similar expansion coefficient, low air bubble generating number and low glass liquid phase temperature with the sealing metal.

The invention relates to a process for improving an arsenic gold concentrate roasting arsenic and sulfur removal rate. The process comprises the steps of adding 3-8% of an additive to arsenic gold concentrate, and carrying out two-sectional roasting treatment; recovering arsenic trioxide from smoke generated from roasting through a cloth bag arsenic collection device, and implementing SO2 purification, SO2 drying, SO2 twice conversion and two-stage absorption on the smoke after arsenic removal to generate 98% of a sulfuric acid product; and recovering valuable metallic gold and silver from a roasting product generated from the roasting through an acid leaching process and a cyaniding process. The process is simple in process, energy-saving and environment-friendly, and capable of effectively improving the arsenic gold concentrate roasting arsenic and sulfur removal rate; and the process can not only increase the yields of an arsenic trioxide product and an sulfuric acid product, but also remarkably improve the recovery rate of the valuable metallic gold in the arsenic gold concentrate; and the process has a remarkable economic benefit.

The present invention relates to a method of treating cancer in a subject in need thereof, by administering to the subject a combination of sodium meta arsenite and / or arsenic trioxide and a cytotoxic anticancer agent, such as cisplatin, adriamycin, and taxane, such as larotaxel, orataxel, tesetaxel, docetaxel or paclitaxel. The arsenic compound(s) and cytotoxic anti-cancer agent may be administered together in a composition or separately as a combination therapy.

The NSAID, sulindac and / or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.

The invention relates to a halobios specimen making technique, concretely a method for making specimens of large marine mammals and fishes, peeling off skin of a sample between corium layer and subcutaneous fat layer, soaking with alcohol and processing with sodium carbonate, processing with arsenic trioxide, soap and camphor, and processing the seam with unsaturated polyester putty. And it overcomes oil overflowing, and keeps original appearance of the sample, having very high economic and social benefits.

The invention relates to a method for directly separating antimony and arsenic from flue dust containing the antimony and the arsenic. The method is characterized in that: the flue dust containing the antimony and the arsenic is conveyed in a reverberatory furnace and is separated to obtain arsenic trioxide and antimony trioxide by using temperature difference; the temperature for separating the arsenic trioxide is 680 DEG C; the arsenic trioxide passes through a air discharge cooling apparatus, and is insufflated in a bag chamber through a fan and collected; the remaining antimony raw material is heated to a temperature of 850 DEG C to carry out a reduction reaction to collect the antimony trioxide. According to the present invention, the collection efficiency of the arsenic trioxide is 98-98.5%, and the collection efficiency of the antimony trioxide is 98-99.8%; the smelting process method is simple; production investment is less; factory constructing and commissioning are quick.

The present invention relates to a new arsenic trioxide anti-tumor use and an anti-tumor preparation. A new arsenic trioxide anti-tumor mechanism is disclosed for the first time, and a drug or a drug box with an antineoplastic use, and a new arsenic trioxide or arsenic-trioxide-related preparation use are provided on the basis of the new arsenic trioxide anti-tumor mechanism.

The present invention provides an oral formulation of arsenic trioxide (As2O3) for the treatment of a variety of hematological malignancies, including acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL). The present invention also provides methods for making the oral arsenic trioxide formulation. Methods of using the oral arsenic trioxide formulation are also described.

The invention discloses an iodide ion detection reagent based on iodide catalyzed hydrazine-[oxidant-Ferroin reagent] and an iodide ion detection method. In an acid medium, a tetravalent cerium solution or potassium permanganate solution is used for oxidizing an orange red Ferroin reagent solution into a blue solution in an acid medium, and a hydrazine saline solution is added to enable the blue solution to generate a reaction that blue is slowly faded to be turned into orange red; iodine has a sensitive oxidizing effect for the reaction, the higher the iodine concentration is, the higher thereaction speed is, a proportional relation is formed between the iodine concentration and the luminance value, and the iodine content of a sample can be calculated by an iodine standard curve. The detection result can be consistent to the result of the iodine tested by adopting a classical arsenic-cerium catalytic photometric method, and the use of a virulent hard-to-purchase arsenic trioxide reagent in the classical arsenic-cerium catalytic photometric method is avoided. The detection method has the advantages of being simple and convenient, rapid, specific, sensitive, accurate and the like,is expected to be widely applied to related fields needing to detect the iodine content of the sample, and especially is applied to urine iodine and water iodine detection in the fields of sanitary inspection and medical technology.

The invention discloses an arsenic-trioxide-carrying pH-responsive mesoporous silica nanoparticle and a preparation method thereof. The preparation method of the arsenic-trioxide-carrying pH-responsive mesoporous silica nanoparticle mainly comprises the following steps: preparing amino modified mesoporous silica by adopting a coprecipitation method, and loading conjugate acid and base ATO and PAA through electrostatic adsorption for preparing PAA-ATO-MSNs. The prepared PAA-ATO-MSNs are circular or quasi-circular in appearance under a transmission electron microscope, average particle size is (158.6+ / -1.32)nm, Zeta potential is (-28.40+ / -0.34)mV, and encapsulation efficiency and drug loading rate are (40.95+ / -3.21)% and (11.42+ / -1.75)% respectively; in vitro drug release is pH-responsive, and accumulated release amount is increased along with reduction of pH value; pharmacokinetic study shows that compared with ATO-Sol and ATO-MSNs, t1 / 2beta of PAA-ATO-MSNs is obviously prolonged and AUC is obviously increased (P is less than 0.01); and PAA-ATO-MSNs in vitro drug release has obvious pH responsiveness and sustained release property, in vivo pharmacokinetic behaviours of a rat can be obviously improved, and the arsenic-trioxide-carrying pH-responsive mesoporous silica nanoparticle carrier can serve as an ATO tumour-targeted drug delivery system and has a good application prospect.

The invention discloses a reagent used for detecting urinary iodine by a biochemistry analyzer and a urinary iodine detecting method. The reagent mainly comprises the following components: digestion solution-ammonium persulfate solution, reagent R1-arsenious acid or arsenic trioxide solution, reagent R2-ceric ammonium sulfate or cerous sulfate solution, and iodine standard solution-potassium iodide (sodium iodide) or potassium iodate (sodium iodate) solution. The detecting method mainly includes the following steps: selecting the detecting reagent, digesting urine sample, setting parameters of the biochemistry analyzer, and determining through the biochemistry analyzer. The detecting method has high automation degree, small human error, little reagent dosage and short detecting time. By adopting the biochemistry analyzer to analyze the urinary iodine, the urinary iodine detecting method expands the detecting items of the instrument, is particularly suitable for the medical organizations equipped with the biochemistry analyzers, and meets the requirements of clinical detection on quick issuing of result and detecting automation.

The invention relates to an aqueous UV (Ultraviolet) photo-curing full-shielding nano transparent heat-insulating coating, comprising the following components in percentage by weight: 30-60% of aqueous UV resin, 5-30% of nano ATO (Arsenic Trioxide) dispersed body, 1-10% of nano LaB6 dispersed body, 1-15% of nano WO3 dispersed body, 2-10% of light initiator and 0.5-1.0% of auxiliary agent. The preparation method comprises the following steps of: agitating and gradually dropwise adding the modified nano ATO, nano LaB6 and nano WO3 dispersed bodies into an aqueous UV pre-polymer; dispersing at a high speed and removing a solvent; and sequentially adding the light initiator, a de-foaming agent, a flattening agent and an accelerating agent, and agitating to prepare the aqueous UV photo-curing full-shielding nano transparent heat-insulating coating. The coating is environment-friendly and is excellent in performance, can be used on the surface of building glass, vehicle glass and resin, and has the very obvious heat insulation performance. The coating can realize automatic assembly line coating and has the advantages of convenience for construction, fast curing peed and high production efficiency.

The invention discloses a resource utilization process for high pressure oxygen continuous leaching of arsenic sulfide slag. The arsenic sulfide slag is treated through high pressure oxygen and then is reduced and extracted so that refined arsenic trioxide, copper sulfate and ammonium rhenate can be obtained; meanwhile, obtained waste acid liquid can be recycled for slurrying of the arsenic sulfide slag; and the whole process is high in recycling rate and free of pollution and is a novel and environment-friendly arsenic sulfide slag recycling process.