99results about How to "Increase kill" patented technology

This invention relates to methods for treating or preventing hepatitis C virus infections in mammals using Toll-Like Receptor (TLR)7 ligands and prodrugs thereof. More particularly, this invention relates to methods of orally administering a therapeutically effective amount of one or more prodrugs of TLR7 ligands for the treatment or prevention of hepatitis C viral infection. Oral administration of these TLR7 immunomodulating ligands and prodrugs thereof to a mammal provides therapeutically effective amounts and reduced undesirable side effects.

The invention concerns immunogens, immunogenic compositions and method for the treatment of gastrin-dependent tumors. The immunogens comprise a peptide from the CCK-B / gastrin-receptor conjugated to a spacer and to an immunogenic carrier. The immunogens are capable of inducing antibodies in vivo which bind to the CCK-B / gastrin-receptor in tumor cells, thereby preventing growth stimulating peptide hormones from binding to the receptors, and inhibiting tumor cell growth. The immunogens also comprise antibodies against the CCK-B / gastrin-receptor for passive immunization. The invention also concerns diagnostic methods for detecting gastrin-dependent tumors in vivo or from a tissue biopsy using the antibodies of the invention.

An alcohol-based composition for sanitizing surfaces has persistent sanitizing properties after evaporation of the alcohol. The composition includes a cationic polysaccharide, an organic acid, alcohol, and water. The cationic polysaccharide can be chitosan, cationic guar or cationic starch. The cationic polysaccharide can be complexed with a transition metal, such as zinc or copper, or with a chelating agent, such as pyrithione.

Air decontamination devices in one example include a filter directly exposed to ultraviolet (“UV”) radiation on an upstream side and a downstream side. Ozone may be provided to permeate the filter, as well. Reflectors may be provided to reflect UV radiation emitted in a direction away from the filter, towards the filter. The filter may be a V-bank filter, for example. Air sampling ports and prefilters may be provided. The air decontamination units may be used to decontaminate the air after industrial and medical contaminations and terrorist biological, chemical and radiological attacks, for example. Mobile isolation units, and methods of decontaminating rooms, are disclosed, as well.

The blood collection, processing and transfer by separation of discrete components containing additional citrate (at least about trisodium citrate 9% w / v) in one or other of collection or processing bag provides for enhanced yield and purity of cryoprecipitate. Inhibiting the activation or denaturation of blood components including blood cells and plasma proteins and with the removal of the activated and denatured components thereby improving safety and efficacy of end products. The inventive process is particularly suited to an improved extraction process to yield concentrated clotting factors from single donors or limited pools without use of chromatography. Following extraction the remaining cryoprecipitate can advantageously be formed into a fibrin fabric used in surgeries and in the treatment of wounds

Fibrosis arises as part of a wound healing response that maintains organ integrity following catastrophic tissue damage, but can also contribute to a variety of human pathologies, including liver cirrhosis. The invention demonstrates that cellular senescence acts to limit the fibrogenic response to tissue damage, thereby establishing a role for the senescence program in pathophysiological settings beyond cancer. Accordingly, the methods of the invention relate to modulating cellular senescence in disease tissue that have elevated numbers of senescent cells, such as in fibrotic tissues.

The blood collection, processing and transfer by separation of discrete components containing additional citrate (at least about trisodium citrate 9% w / v) in one or other of collection or processing bag provides for enhanced yield and purity of cryoprecipitate. Inhibiting the activation or denaturation of blood components including blood cells and plasma proteins and with the removal of the activated and denatured components thereby improving safety and efficacy of end products. The inventive process is particularly suited to an improved extraction process to yield concentrated clotting factors from single donors or limited pools without use of chromatography. Following extraction the remaining cryoprecipitate can advantageously be formed into a fibrin fabric used in surgeries and in the treatment of wounds.

The invention provides methods of treating neoplastic disorders in a mammal through the inhibition of Mer and / or AxI receptor tyrosine kinases as well as compounds and compositions useful for inhibiting these kinases in these methods. These treatment methods may be combined with the administration of one or more chemo therapeutic agent(s) to enhance the efficacy or minimize the toxicities of the chemotherapeutic agent(s).

The present invention provides compositions comprising a chimeric molecule comprising a cytotoxin that inhibits protein synthesis and an agent that inactivates an anti-apoptotic BCL-2 family member protein and methods of inhibiting the growth of or promoting the apoptosis of an aberrantly proliferating cell population by co-administering the chimeric molecule and the agent that inactivates an anti-apoptotic BCL-2 family member protein.

The current invention relates to a process for increasing the efficacy of cancerous disease inhibiting therapeutic agents delivered to a treatment region of a tissue structure, such as a tumor. The multi-step procedure takes advantage of the resulting thermal stress response occurring as a result of exposure to the cold. Coordinating the thermal related stress response with the timing of cancerous disease inhibiting agent action provides a unique therapeutic regiment to treat tumors which provides a maximized effect on the tumor, protects normal cells, and activates local pro-inflammatory cells.

Compositions and methods for inducing cell membrane wounding, cell permeabilization and cell killing are provided. The composition comprises a polyvalent agent that binds to a highly expressed cell surface antigen present on the surface of a cell. Preferably, the cell surface antigen is associated with the cytoskeleton of the cell. A preferred polyvalent agent is an IgM, and enhanced cell wounding and killing can be provided by the addition of a crosslinking agent. At sublethal concentrations in vivo, the cell wounding antibodies permeabilize cells and dramatically enhance response to chemotherapeutic agents, even in patients refractory to the chemotherapeutic agents.

An ozone-based water purification system is disclosed. In this system, a mixing venturi injects ozone and a liquid sanitizer into a stream of water to be treated. Following ozone and sanitizer injection, the stream of water is passed to a contact region where the ozone and sanitizer are allowed to react with contaminants and biota. The stream is then mixed by several mixing devices to allow residual ozone and sanitizer to further react with contaminants and biota. Particularly a counterflow system is employed wherein the stream is directed downward at several points so that bubbles containing ozone are forced to flow upward against the flow, lengthening ozone contact time. Also, the ultraviolet lamp used to generate ozone is mounted so that ultraviolet light therefrom is exposed to the flow water, providing additional sterilizing effects. In addition, a novel mixing venturi is disclosed that mixes a gas containing ozone and a liquid sanitizer into a motive flow of water.

The invention relates to a composite albumen powder for improving immune capability. The composite albumen powder comprises the following components in percentage by weight: 65 to 75 percent of soy isolate protein, 10 to 30 percent of concentrated whey protein, 1 to 10 percent of cherry powder, 1 to 10 percent of synanthrin and 1 to 5 percent of dietary fiber flour. The cherry powder, the synanthrin and the dietary fiber flour are matched with the soy isolate protein and the concentrated whey protein reasonably in scientific amount and are synergic to improve immune capability; and the composite albumen powder is comprehensive in nutrition and easy to absorb.

The invention relates to a Chinese medicinal composition for treating cancer, wherein the raw material comprises include (by weight ratio): gelsemium elegans 1-3g, dandehon herb 10-15g, honeysuckle flower 10-15g, yellow corktree bark 10-15g, capsule of weeping forsythia 10-15g, red peony root 10-15g, dried rehmannia root 15-20g, root bark of tree peony 7-10g, and cape jasmine 10-15.

This invention relates to novel analogs of pituitary adenylate cyclase-activating polypeptide (PACAP), which are agonists for the PACAP / vasoactive intestinal peptide (VIP) receptors: PAC1, VPAC1 and VPAC2 receptors. These PACAP analogs can be used as prophylactic / therapeutic agents for a wide range of medical disorders, including (but not limited to) cancer and autoimmune disease. These PACAP analogs can be coupled to suitable radionuclides and used in the localization, diagnosis and treatment of disseminated cancers and metastatic tumors, or coupled to small molecule therapeutics and used as vectors for targeted drug delivery. This invention also provides pharmaceutical compositions of one or more PACAP-like compounds of the invention either alone or in combination with one or more other prophylactic / therapeutic agents.

The increasing use of nanotechnology in consumer products and medical applications underlies the importance of understanding its potential toxic effects to people and the environment. Herein are described methods and assays to predict and evaluate the cellular effects of nanomaterial exposure. Exposing cells to nanomaterials at cytotoxic doses induces cell cycle arrest and increases apoptosis / necrosis, activates genes involved in cellular transport, metabolism, cell cycle regulation, and stress response. Certain nanomaterials induce genes indicative of a strong immune and inflammatory response within skin fibroblasts. Furthermore, the described multiwall carbon nanoonions (MWCNOs) can be used as a therapeutic in the treatment of cancer due to its cytotoxicity.

The present invention discloses a piglet intakepromoting feed, which comprises the following raw materials by weight: 40 to 43 parts of corn flour, 10 to 13 parts of pine needle powder, 10 to 12 parts of sweet potato powder, 14 to 16 parts of fermented bean dreg, 10 to 15 parts of fermented soybean meal, 7 to 9 parts of peanut meal, 3 to 5 parts of rice wine distiller's grain, 20 to 25 parts of steamed bone powder, 8 to 9 parts of zeolite powder, 5 to 6 parts of montmorillonite powder, 0.5 to 0.8 part of vitamin A, 0.7 to 1.1 parts of vitamin E, 8 to 9 parts of calcium bicarbonate, 10 to 12 parts of calcium carbonate, 0.3 to 0.4 part of lysine, 0.1 to 0.2 part of sodium glutamate, 0.3 to 0.5 part of salt, 0.05 to 0.08 part of cheese flavor, 1 to 3 parts of a sweetening agent and 4 to 6 parts of Chinese medicine powder. The piglet intake promoting feed has characteristics that: the odor is fragrant, the palatability is good, the digestion and absorption rate is high and the nutrition is comprehensive and balanced. By adding with a plurality of Chinese medicine that has effects of spleen strengthening and digestion promoting, the digestion and absorption of piglet are further promoted.

Compositions and methods for inducing cell membrane wounding, cell permeabilization and cell killing are provided. The composition comprises a polyvalent agent that binds to a highly expressed cell surface antigen present on the surface of a cell. Preferably, the cell surface antigen is associated with the cytoskeleton of the cell. A preferred polyvalent agent is an IgM, and enhanced cell wounding and killing can be provided by the addition of a crosslinking agent. At sublethal concentrations in vivo, the cell wounding antibodies permeabilize cells and dramatically enhance response to chemotherapeutic agents, even in patients refractory to the chemotherapeutic agents.

The invention relates to a compound preparation for treating the virosis of birds and the preparation method of the compound preparation. The compound preparation is prepared by mixing raw materials by weight portions, 20 to 50 parts of milk veteh and 30 to 50 parts of grifola frondosa. Preparation procedures are as follow: The raw materials are extracted by soaking, decocted by heating and precipitated by filtering; therefore the Chinese herbal medicine is prepared. The compound preparation has the beneficial effect as follows: (1) the new preparation that can control the virosis of the birds and strengthen the disease resistance of organism is created for clinical treatment; (2) the compound mode is reasonable, the antiviral capability is strong and all the selected medicine is the effective medicine for treating the virosis of birds; (3) the compound preparation has the advantages of advanced technology, stable preparation and long storage life; (4) the compound preparation has the advantages of being safe to use, definite healing effect and controllable quality; (5) the compound preparation has the advantages of wide source of the raw materials, being avirulent, no side effect and being uneasy to cause drugfastness, so as to meet the standard of international hygienic examination. The compound preparation is especially applicable for treating infectious bursal disease, atypical newcastle disease and infective bronchitis, and the treating effect is remarkable.

Filarial parasites Brugia, Wuchereria, Loa Loa and Onchocerca cause over 20 million infections worldwide and pose a significant social and economic burden in endemic areas. The invention provides compositions and methods to treat parasitic infections in animals and plants, and to kill and inhibit the replication of parasites in infected hosts. The methods can include administering to a host in need of treatment an effective antiparasitic amount of a composition comprising biodegradable polyanhydride microparticles or nanoparticles that encapsulate antiparasitic agents, optionally in combination with antibacterial agents. Through co-encapsulation of antiparasitic and antibacterial agents into the particles, the invention provides the ability to effectively kill parasitic helminthes, worms, and flukes, with up to a 40-fold reduction in the amount of drug used. The results described herein demonstrate the effectiveness of the drug carriers to reduce both the course of treatment and the amount of drug needed to treat parasitic infections.

The invention discloses a pig feed with effects of invigorating stomach and helping digestion as well as improving immunity. The feed comprises the following raw materials in parts by weight: 40-43 parts of corn flour, 10-13 parts of sorghum flour, 10-12 parts of wheat bran, 14-16 parts of fermented bean dregs, 10-15 parts of fermented bean pulp, 7-9 parts of rapeseed dregs, 1-3 parts of yeasts, 20-25 parts of full-fat fish meal, 8-9 parts of talcum powder, 5-6 parts of montmorillonite powder, 0.5-0.8 part of vitamin A, 0.7-1.1 parts of vitamin E, 8-9 parts of calcium bicarbonate, 10-12 parts of calcium carbonate, 3-4 parts of calcium formate, 0.3-0.4 part of lysine, 0.1-0.2 part of sodium glutamate, 0.3-0.5 part of salt, 0.05-0.08 part of cheese flavor, 1-3 parts of sweetening agent and 4-6 parts of traditional Chinese medicine powder. The pig feed is good in flavor and aroma, high in palatability and digestive absorption rate and comprehensive and balanced in nutrition, and due to addition of the traditional Chinese medicines with the effects of invigorating stomach and helping digestion, digestive absorption of middle pigs is further promoted.

The invention discloses a method for synchronously preventing and controlling fruit cracking and a fruit shrinking disease of ziziphus jujuba mill, namely, key mineral element supplementation, chemical prevention and growth regulator application are combined. The method is characterized in that soil fertilization is carried out by mixing potassium sulfate and manganese sulfate according to a certain proportion, and sodium silicate and calcium chloride are sprayed on leaves, so that key mineral elements and beneficial elements can be effectively supplemented, nutrient balance can be regulated, and the resistance is increased; 6-BA (Benzyladenine) is sprayed on the leaves in an early stage, so that pericarpic cell division is stimulated, and elasticity of jujube peel is enhanced; NAA (Naphthalene Acetic Acid) is sprayed in a later stage, so that maturing of jujube fruits is delayed, and a cloudy and rainy period in the early of mid September is avoided; mancozeb is sprayed on the leaves, so that pathogenic bacteria on body surface can be effectively killed, a layer of dense protective medicine membrane is formed on the surface of crop, and germination and invasion of the pathogenic bacteria are inhibited. According to the method disclosed by the invention, the morbidity of the fruit cracking and the fruit shrinking disease of the ziziphus jujuba mill can be synchronously and obviously reduced, and a total diseased fruit rate can be reduced from 80 to 100 percent to 20 percent or less. A technology is applied to prevention and control of the fruit cracking and the fruit shrinking disease of the ziziphus jujuba mill, the method is simple, the cost is low, the prevention and control efficiency is high, and the effect is lasting.

This invention relates to novel analogs of pituitary adenylate cyclase-activating polypeptide (PACAP), which are agonists for the PACAP / vasoactive intestinal peptide (VIP) receptors: PAC1, VPAC1 and VPAC2 receptors. These PACAP analogs can be used as prophylactic / therapeutic agents for a wide range of medical disorders, including (but not limited to) cancer and autoimmune disease. These PACAP analogs can be coupled to suitable radionuclides and used in the localization, diagnosis and treatment of disseminated cancers and metastatic tumors, or coupled to small molecule therapeutics and used as vectors for targeted drug delivery. This invention also provides pharmaceutical compositions of one or more PACAP-like compounds of the invention either alone or in combination with one or more other prophylactic / therapeutic agents.

An adjustable Venturi is disclosed, and having a plurality of inlet ports providing substances to be mixed with a flow of fluid through the Venturi. In one embodiment, the Venturi is constructed having an inlet portion, an outlet portion, with an annular mixing chamber coupled to inlet ports so that substances provided through inlet ports are mixed in the mixing chamber, and such mixture introduced into the flow. A gasket sealably disposed between inlet portion and outlet portion is selectable in thickness, for adjusting width of a Venturi interface between the inlet portion and outlet portion. In another embodiment, the inlet portion and outlet portion are fitted in an elongated opening, and are replaceable to change operational characteristics of the Venturi. A replaceable disk having a central opening and substance-providing passageways is disposed between the inlet portion and outlet portion, and may be changed to change characteristics of the Venturi.

Water-soluble polymer conjugates of antimicrobial agents retaining at least a portion of the antimicrobial activity of the agent, pharmaceutical compositions containing the polymer conjugates, and methods for treating microbial infections with the pharmaceutical compositions.

Cyclosporin A has been discovered to sensitize cancers resistant to TNF-family death receptors such as TRAIL and Fas to ligand-mediated apoptosis. Therefore, compositions that include cyclosporin A are useful in treating such cancers.

The present disclosure generally relates to filter media compositions, apparatuses and systems for removing contaminants from fluids, as well as methods of using the same. In certain aspects the filter media comprises on or more halogenated resins (103) and one or more contaminant sorbent media (102, 104, 105, 106). The filter media of the present disclosure may be self-contained in a single unit or certain components may be housed in separate units acting in parallel or in series.

The invention discloses a biochemical sludge swelling control system and a control method thereof, and belongs to the technical field of biological sewage treatment. The system disclosed by the invention comprises a water inlet, a secondary sedimentation tank and a water outlet, wherein the bottom end outlet of the secondary sedimentation tank is connected with a sludge return pipeline; a sludge return pump, a clipper and an H2O2 dosing pipe are sequentially mounted on the sludge return pipeline according to the flow direction of sludge in the sludge return pipeline; the sludge return pipeline and the water inlet are connected to the water inlet end of an elutriation pool; a Ca(ClO)2 dosing pipe and a first aerating branch pipe are arranged in the elutriation pool, the water outlet end of the elutriation pool is connected with an aerobiotic pool, and a second aerating branch pipe is arranged in the aerobiotic pool; the secondary sedimentation tank is connected with the aerobiotic pool through a pipeline, and a water outlet is formed in the secondary sedimentation tank. Through technological improvement, the system and method disclosed by the invention sort out and solve the problem of sludge settleability in a targeted manner, so that sludge swelling can be effectively controlled in a short term.

The invention relates to the technical field of waste gas treatment, in particular to a light and oxygen catalytic waste gas treatment system, and solves the problem of poor waste gas treatment effectof the waste gas treatment system in the prior art. The light and oxygen catalytic waste gas treatment system has the main technical scheme that the light and oxygen catalytic waste gas treatment system comprises a pretreatment device, a light and oxygen catalytic reaction device and a product collection device, wherein the light and oxygen catalytic reaction device comprises a casing and baffleplates in laminated crossing arrangement; an ultraviolet ray emitter is arranged in a position, right aligned with each baffle plate, on the casing; a reaction passage is formed between the baffle plate and the casing; sulfur dioxide and hydrogen sulfide in the waste gas are removed through the pretreatment device; the waste gas and the bacteria in the waste gas are cracked through the light and oxygen catalytic reaction device; through the product collection device, the generated carbon dioxide is collected, so that the waste gas is efficiently treated; the environment pollution is reduced.

The increasing use of nanotechnology in consumer products and medical applications underlies the importance of understanding its potential toxic effects to people and the environment. Herein are described methods and assays to predict and evaluate the cellular effects of nanomaterial exposure. Exposing cells to nanomaterials at cytotoxic doses induces cell cycle arrest and increases apoptosis / necrosis, activates genes involved in cellular transport, metabolism, cell cycle regulation, and stress response. Certain nanomaterials induce genes indicative of a strong immune and inflammatory response within skin fibroblasts. Furthermore, the described multiwall carbon nanoonions (MWCNOs) can be used as a therapeutic in the treatment of cancer due to its cytotoxicity.