Patents
Literature
2 results about "Death Receptors" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Use of a combination of a dr5 agonist and an immune checkpoint inhibitor in the manufacture of a medicament for treating a tumor
PendingCN122251603AOrganic active ingredientsMicrobiological testing/measurementAntiendomysial antibodiesTumor therapy
The application belongs to the field of biological medicine, and relates to a combination of a DR5 agonist and an immune checkpoint inhibitor for preparing a drug for treating tumors. The application provides application of a death receptor 5 agonist in preparation of an anti-tumor drug in combination with one or more of a PD-1 inhibitor, a PD-L1 inhibitor, a NKG2A inhibitor and a chemotherapeutic drug. It is found that the DR5 agonistic antibody can further increase the single drug efficacy of the immune checkpoint inhibitor. On this basis, the DR5 agonistic antibody and the immune checkpoint inhibitor can also be combined with chemotherapy to further improve the effect of immunotherapy. The application can further promote the development of immunotherapy in the field of tumor treatment, optimize the tumor treatment pattern, and is expected to be applied in the clinic to improve the tumor treatment effect and the survival rate of patients.
Owner:SUN YAT SEN UNIVERSITY CANCER CENTER (CANCER HOSPITAL AFFILIATED TO SUN YAT SEN UNIVERSITY CANCER RESEARCH INSTITUTE OF SUN YAT SEN UNIVERSITY)
