Patents
Literature
1 results about "Negative selection" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
In natural selection, negative selection or purifying selection is the selective removal of alleles that are deleterious. This can result in stabilizing selection through the purging of deleterious genetic polymorphisms that arise through random mutations.
Methods to enrich nucleotide variants by negative selection
Provided herein are methods for selectively depleting a target nucleic acid comprising a sequence that does not comprise a nucleotide variant of interest. In some embodiments, a concentration of the target nucleic acid comprising the variant sequence is increased relative to a concentration of the target nucleic acid comprising the wild-type sequence, a concentration of the target nucleic acid comprising a converted nucleotide is increased relative to a concentration of the target nucleic acid that does not comprise the converted nucleotide, or a concentration of the target nucleic acid that does not comprise the converted nucleotide is increased relative to a concentration of the target nucleic acid comprising the converted nucleotide. In some embodiments, the target nucleic acids are sequenced.
Owner:GUARDANT HEALTH INC