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Arsenic trioxide control release elution stent

A technology of arsenic trioxide and eluting stents, which is applied in the fields of drugs and medical devices to induce apoptosis, inhibit intimal hyperplasia, and prevent restenosis

Inactive Publication Date: 2005-08-24
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether it can be used for in-stent restenosis and prevent neointimal hyperplasia has not been reported

Method used

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  • Arsenic trioxide control release elution stent
  • Arsenic trioxide control release elution stent
  • Arsenic trioxide control release elution stent

Examples

Experimental program
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Embodiment 1

[0014] Preparation of As 2 o 3 Controlled Release Eluting Stent

[0015] Adopt polybutyl methacrylate / silicon dioxide (nano) composite controlled release material and medicine to mix and be coated on the surface of stainless steel stent, described polybutyl methacrylate / nanometer silicon dioxide composite material coating and PLGA double coating Coating for drug controlled release. First prepare a 1% tetrahydrofuran solution of polybutylmethacrylate, which contains 25-30% of the polymer content of nano-silica, as a controlled release coating, the As 2 o 3 Add the powder into the solution so that the weight ratio of the drug to polybutylmethacrylate is 1:1, stir to suspend the drug in the solution, spray the suspension evenly on the stent with a spray gun, and dry it at 40°C as an internal coating layer, and accurately weighed so that the drug content per square millimeter of the stent surface is 1.6-3.2 μg. Prepare a 1% chloroform solution of PLGA, spray evenly on the out...

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Abstract

An elution stent with controlled release of As2O3 for preventing and treating coronary heart disease features that the As2O3 is used as the stent medicine and the dual coated layers including the coated butyl polymethylatel nano-SiO2 layer and the coated PLGA layer are used to control the release of As2O3 for inducing the wither of smooth muscle cells at the second stage of damaged blood vessel.

Description

technical field [0001] The invention belongs to the field of drugs and medical devices, and relates to a drug-eluting stent for preventing restenosis after implantation of a coronary artery stent, in particular to an arsenic trioxide controlled-release eluting stent. Background technique [0002] At present, one of the main problems in the field of coronary interventional cardiology is restenosis after stent implantation. A large number of research results show that systemic medication cannot obtain satisfactory results. Drug-eluting stents, which use stents as delivery carriers and allow drugs to act locally in damaged coronary arteries, have the advantages of high local drug concentration and low systemic side effects, and are expected to become an effective way to solve restenosis after stent implantation. The proliferation and migration of vascular smooth muscle cells (SMC) is the main cause of vascular intimal hyperplasia and restenosis. At present, most drugs are selec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/06A61K33/36A61L27/00A61M29/00
Inventor 孙宝贵赵军礼钟伟
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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