112results about How to "Prevent stenosis" patented technology

The present invention relates to methods for inhibiting stenosis, obstruction, or calcification of a valve following implantation of a valve prosthesis which may involve disposing a coating composition on an elastical stent and securing the valve prosthesis which may have a collapsible elastical valve mounted on the elastical stent such that the elastical stent may be in contact with the valve.

A multiple lumen catheter assembly comprising a first catheter having a proximal end and a distal end, a second catheter having a proximal end and a distal end; and a connecting means for selectively joining at least a portion of the distal ends of the first and second catheters.

The present invention provides materials and methods for preventing stenosis or restenosis of a blood vessel using Vascular Endothelial Growth Factor C (VEGF-C) and / or Vascular Endothelial Growth Factor D (VEGF-D) genes or proteins.

The present invention provides materials and methods for preventing stenosis or restenosis of a blood vessel using Vascular Endothelial Growth Factor C (VEGF-C) and / or Vascular Endothelial Growth Factor D (VEGF-D) genes or proteins.

A multi-pole electrode catheter for heat-induced renal nerve regulation, comprising: a control handle; a catheter body, one end of the catheter body is fixed to the control handle, and the other end of the catheter body is closed; it is fixed on the catheter body On the other end of the catheter, multiple point-like electrodes are arranged in a staggered manner, each electrode can be used to extract electrical signals and ablate, each electrode is connected with a wire, and the wire extends through the cavity of the catheter tube body to the control handle , so as to be electrically connected with the control handle. The multi-pole point-shaped electrode catheter only heats the adherent tissue with radiofrequency and does not heat the blood.

In a cardiac ablation procedure, ultrasonic energy is emitted from an ultrasonic ablation device (28) and is focused on myocardial tissue (30) within the wall of the heart or within the wall of a blood vessel connected to the heart (10). Ultrasound attenuation of the cardiac tissue is selectively increased by introducing microbubbles into the circulatory system of the subject so that the microbubbles enter the coronary arteries and pass into the myocardial tissue.

The invention relates to a multi-electrode ablation catheter which comprises a catheter, electrodes distributed on the catheter, a wire connected onto the electrodes to transmit signals and radio frequency energy and a handle used for adjusting the shape of the catheter. The electrodes comprise basket-shaped electrodes and head electrodes arranged at the farthest end of the catheter. The catheter comprises a basket-shaped section with the basket-shaped electrodes, a flexible transition section and a main body section coupled to the handle, wherein the basket-shaped section is formed by a center catheter and a plurality of branch catheters evenly distributed around the center catheter and connected with the center catheter at two ends. The basket-shaped electrodes are formed by electrodes distributed on the branch catheters, and contracting, base state and stretching of the branch catheters relative to the center catheter are achieved by controlling the handle. The catheter can be contracted to conveniently enter the renal artery vessel to be transferred to the position nearby a target spot of a complex structure, the catheter can extend after the catheter reaches the place to cling to the vessel wall completely, protrusions are not formed in the middle, the problem that the vessel is irritated to be narrow due to the fact that a certain position is ablated too much is solved, and blood flow of the renal artery is not affected.

An elution stent with controlled release of As2O3 for preventing and treating coronary heart disease features that the As2O3 is used as the stent medicine and the dual coated layers including the coated butyl polymethylatel nano-SiO2 layer and the coated PLGA layer are used to control the release of As2O3 for inducing the wither of smooth muscle cells at the second stage of damaged blood vessel.

The invention discloses a preparation method of nano superfine fiber vascular prosthesis, which comprises the following steps that: the mixed solution of N, N-dimethylformamide and tetrahydrofuran in the mass ratio of 3:7 serves as solvent to prepare polyurethane spinning solution with the mass percentage of 10 percent, and the polyurethane spinning solution stays still and is deaerated; the prepared spinning solution is put into a solution storage device of an electro-spinning device, and the flow rate of the spinning solution is adjusted; according to the preparation requirements, receiving sticks with different diameters are selected; the distance between an injection device of the electro-spinning device and the receiving sticks is adjusted; the receiving sticks are grounded; and a high-voltage static generator is turned on, the static spinning voltage is set, a high-voltage power supply supplies a strong electric field between the injection device and a collection device, after a period of time is waited, the power supply is disconnected, the receiving sticks are detached, and the vascular prosthesis is taken down. The vascular prosthesis which is prepared by the electro-spinning device and the special solution has rich porosity, facilitates inner and outer layered material exchange and cell signal transduction, and prevents cells from migrating and proliferating towards the subendothelial layer and causing vein stenosis.

The invention relates to a thermoplastic degradable fabric woven bracket and a preparation method thereof. The thermoplastic degradable fabric woven bracket is a hollow pipe formed through crosswise weaving thermoplastic degradable fabrics; and fabrics are bonded together in the crossed points. The preparation method comprises the following steps: (1) weaving the degradable fabrics into the pipe with a net structure; (2) bonding the fabrics in the pipe in the crossed points in a heat treatment or thermo-compression way to prevent fabric loosing, so that the bracket has a higher radial supporting force; (3) after the pipe is coated with carapace-acetic acid-water solution, placing into absolute ethyl alcohol to form a carapace coating; and (4) removing ethanol from a vacuum oven to obtain the thermoplastic degradable fabric woven bracket with the carapace coating. The bracket has a higher radial supporting force, and can be completely degraded in the human body.

The invention provides a circular anastomat for clinical gastrointestinal surgery. The circular anastomat comprises a handle assembly, a gun body, a nail cartridge assembly and a nail propping seat assembly which are sequentially connected and arranged; the nail container assembly comprises a nail container housing, a circumferential cutting knife and a nail container; the nail container is in connection fitting with the circumferential cutting knife; the nail propping seat assembly comprises a nail propping seat, a central rod and a knife gasket; the nail container is in contact fitting with the nail propping seat; a nail container fitting surface and a nail propping seat fitting surface are respectively formed at the fitting parts of the nail container and the nail propping seat; the circumferential cutting knife is in contact fitting with the knife spacer; a circumferential cutting knife fitting surface and the knife gasket fitting surface are respectively formed at the fitting parts of the circumferential cutting knife and the knife gasket; the nail container fitting surface, the nail propping seat fitting surface, the circumferential cutting knife fitting surface and the knife gasket fitting surface are all the circumferential curved surfaces which are arranged in a convex and concave way in the circumferential direction. According to the circular anastomat for clinical gastrointestinal surgery, the circumference of the part in which the nail container assembly and the nail propping seat assembly is designed into a shape of a concave-convex curved surface, and therefore, anastomosis lines are in different level, and an anastomosis opening of an intestinal tube is telescopic, and as a result, the problem that the anastomosis opening is hardened and narrow to influence the smooth passing in the cavity and even lead to closing of the cavity can be avoided.

The invention relates to a renal sympathetic nerve removing radiofrequency ablation electrode and system. The renal sympathetic nerve removing radiofrequency ablation electrode comprises a first electrode and a second electrode which are opposite in polarity. The two electrodes with the opposite polarities can effectively control the current flowing direction and range, and the radiofrequency ablation energy is concentrated, so that the renal sympathetic nerve on the outer wall of the renal artery blood vessel is burnt out accurately, unwanted injuries to organs and tissues outside the target treatment range are avoided, and the advantage of small destructiveness is achieved. Besides, as the radiofrequency ablation energy is concentrated, the renal sympathetic nerve on the outer wall of the renal artery blood vessel can be burnt out accurately and rapidly, the operating time is shortened greatly, and postoperative recovery of patients is facilitated.

The invention relates to a medical product for interventional therapy, in particular to a novel intravascular coated stent which comprises a stent body and a coat. The coat comprises a polymer bottom layer formed by coating on the surface of the stent body and multilayer silk peptide layers and chitosan layers which are formed by coating on the surface of the polymer bottom layer, wherein the silk peptide layers and the chitosan layers are arranged alternately. A stent coat is prepared by a method of layer upon layer electrostatic self-assembly, has better compatibility with blood, and can reduce late restenosis rate of stent post-operative heart.

The invention discloses a preparation method of novel anticoagulant stents coating capable of capturing endothelial progenitor cells, which comprises the following steps: performing hydroxylation processing on surface of a material, then dissolving dopamine in a Tris-base(pH is 8.5, 2mg / ml) solution, then depositing a layer or multilayer dopamine membrane at temperature of 37 DEG C on the surface of the material, then adjusting reaction condition according to pH and EDC / NHS concentration, and performing covalent grafting on a mixture of CD133+(0.8-3.2ug / ml) and Fucoidan(50-400ug / ml) at temperature of 37 DEG C to obtain a target product. The preparation method has the advantages of simple operation, mild reaction condition, high efficiency and low cost. A target coating has strong antithrombotic performance, anticoagulation and inhibition of endometrial hyperplasia of smooth muscle due to effect of low molecular weight Fucoidan, can rapidly capture the endothelial progenitor cells of peripheral blood so as to induce the endothelial progenitor cells to differentiate for obtaining endothelial cells, and then a complete endothelial cells layer is formed, and the novel anticoagulant stents coating has excellent anticoagulation performance and biological compatibility.

A magnetic sensor comprises magnetoresistor thin films used in view of improvement of identification accuracy of operation of the magnetic sensor so as to prevent degradation of the degree of freedom of arrangement attributed to the narrow intervals between the magnetoresistor thin films. The number of magnetoresistive elements for canceling the harmonics can be increased to an extent that the production of the magnetic sensor does not became difficult while flexibly adjusting the intervals between magnetoresistive elements. The thermal characteristics are uniformed and the identification accuracy is improved. The magnetic sensor has magnetoresistance pattern where magnetoresistor thin films are formed on a substrate, and the magnetoresistance pattern is composed of A-phase and B-phase magnetoresistance patterns which output two signals having phases which are different by 90 DEG. The magnetic sensor is characterized in that the magnetoresistance pattern is formed by combining two substrates.

The invention discloses a small and medium diameter artificial blood vessel with adjustable pressure and flow. The artificial blood vessel comprises a blood vessel wall, a blood vessel cavity is in the blood vessel wall, and a pressure and flow controller capable of adjusting the diameter of the artificial blood vessel is arranged outside the artificial blood vessel. Concave and convex grains are arranged on the blood vessel wall. The pressure and flow controller comprises a fixed shell and a control spring, wherein the fixed shell takes the shape of a cylindrical structure, and the control spring is configured to be a cylindrical structure, the control spring is arranged in the fixed shell and sleeved outside of the blood vessel wall of the artificial blood vessel, the control spring is provided with a limit spring handle for adjusting the diameter of the blood vessel, and the spring handle passes through a control frame. The fixed shell is provided with position fixing holes, and the control spring is provided with position fixing holes. The fixed shell is provided with a fastener. The pressure and flow controller comprises a mechanical pressure and flow controller, an in-vitro remote control pressure and flow controller and an in-vivo induction pressure and flow controller. The blood vessel is applicable to controlling the size of fractional flow according to an induced pressure of a hepatic portal vein after a portosystemic blood vessel is anastomosed and shunted so as to ensure the hepatic portal vein perfusion pressure required by individuals.

The invention relates to a human orificial pipe substitute with baffle edge. Wherein, it is formed by support tube, connector, flexible film and baffle edge; the flexible film is adhered on the support tube; the baffle edge is connected to the end of support tube; the connector is fixed on the support tube. The inventive support tube can effectively avoid around organism to contract to be neck; the connector can effectively reduce the creep of normal orificial pipe to avoid affecting the anastomotic stoma, to obtain firm connection; and the baffle edge can effectively disperse the stress at the anastomotic stoma, to avoid narrow anastomotic stoma. The invention can be made into artificial gullet or trachea.

The invention discloses a colon ligature anastomosis stent which comprises a bypass pipe made from degradable material that is acceptable to the human body; the middle part of the bypass pipe is tubiform, and the two ends of the bypass pipe are respectively provided with a widening funnel-shaped opening; a groove is arranged in a connection section in which the tubiform middle part is connected with the funnel-shaped opening. During the anastomosis, the stent is put in an intestinal cavity, and colon is fixed on the stent by a wire at the groove; the two ends of the colon are in contact with each other in the centre of the vertical axis of the stent, grow and heal, thus realizing the anastomosis of the colon. The colon ligature anastomosis stent can simplify the operation, shorten the operation time and reduce the incidence rate of anastomotic leakage and anastomotic stenosis.

A tissue engineering combined human body lumen succedaneum adopts a tectorial elastic supporting pipe with connecting pieces, wherein an absorbable coating is attached on the outer wall of the supporting pipe, and planted with seed cells thereon. The connecting pieces can reduce the effect of the gullet peristalsis to the planted elastic supporting pipe, and the elastic supporting pipe has favorable flexibility and stronger supporting force, therefore, the tissue engineering combined human body lumen succedaneum provided by the invention can avoid anastomotic leakage, early trachea cannula exodus and newly-born narrow gullet; in addition, the absorbable coating attached on the outer wall of the elastic supporting pipe is planted with the seed cells, thus being capable of inducing or improving the growth and covering of the newly-born esophageal mucosa. After the newly-born esophageal mucosa is covered completely, and the scar tissues of newly-born gullet are stable, the planted succedaneum can be taken out or removed under the direct view of a digestive endoscopy.

The invention discloses a degradable biliary duct drug-eluting stent, which consists of a biliary duct stent body and a biodegradable high-molecular polymer coating arranged on the surface of the biliary duct stent body. The biliary duct stent body is formed by mixed braiding of biodegradable metal wires and biodegradable high-molecular material silk threads. The biliary duct stent body is of a tubular structure. The two ends of the biliary duct stent body are shaped like trumpets that are open outwardly. The surface of the biliary duct stent body is a netted surface. The biodegradable high-molecular polymer coating carries drugs. The degradable biliary duct drug-eluting stent plays a mechanical supporting effect in a short period, is completely degraded after a treatment effect disappears, prevents tube wall tissues from being stimulated for a long period of time, effectively prevents the wall tissues from narrowing again after an operation, enables drug loaded fiber films to evenly wrap the surface of the stent body, and makes the drugs release slowly.

The invention relates to an automatic hemorrhoids ligation device with raised strips. The automatic hemorrhoids ligation device comprises a rubber ring body, a rubber ring tube, a rubber ring tube connector, a suction tube connector, a suction tube, an advancing tube, a reset spring, a transmission tube, a trigger and a handle, wherein the advancing tube, the reset spring and the transmission tube are arranged on the outer peripheral face of the suction tube; one end of the reset spring is connected with the advancing tube, and the other end of the reset spring is connected with the transmission tube; the near end of the suction tube is connected with the handle; the rubber ring tube connector and the rubber ring tube are integrally formed, the rubber ring tube connector is a standard part, and the rubber ring tube connector can be correspondingly connected with rubber ring tubes of different inner diameters; the rubber ring body is provided with the raised strips, and the raised strips are annularly distributed on the inner side of the rubber ring body in an equal-distance manner to form an occlusion part. The automatic hemorrhoids ligation device has the advantages that the device can be matched with hemorrhoids of different sizes, ligation can be achieved through occlusion, and the device is resistant to wetness and slipperiness, firm in fixation and less prone to falling off.

The invention discloses an anorectal ligation device. A left handle and a right handle are subjected to ultrasonic fusion welding; a gun rod comprises an inner cavity tube and an outer sleeve; a suction nozzle is connected to the front end of the inner cavity tube; the back side of the inner cavity tube is inserted into a tee tube and is fixed by virtue of a fixed clamping seat; a rear port of the inner cavity tube is connected with a first nozzle of the tee tube; a second nozzle of the tee tube is connected to a negative-pressure suction connector at the lower ends of the handles; the negative-pressure suction connector is connected to a negative-pressure source; a third nozzle of the tee tube is provided with a plug which is connected to a negative-pressure release switch on the side faces of the handles; the outer sleeve sleeves the inner cavity tube; a push sleeve is connected to the front end of the outer sleeve; the front side of the push sleeve is close to the suction nozzle and is capable of sliding forward along the suction nozzle; a ligation ring sleeves an outer circle at the front end of the suction nozzle; a guide block is fixedly connected to the back end of the outer sleeve; a spring is arranged between the guide block and the front end of the handle; and the lower end of the guide block is in transmitted connection to a trigger switch which is arranged on the handle. The anorectal ligation device achieves automatic implementation in a whole process of ligation treatment; the anorectal ligation device are safer to patients; a surgical operation can be completed by a single person within a short time; and after diagnosis and treatment, the probability of complications is low.

The invention relates to a biliary tract support, which comprises tubular main body made from the material matched with body; the first protruded ring, the second protruded ring, and the extending part far away the second protruded ring, wherein the invention can avoid stitching match open, to save time, avoid directly function biliary tract match open with bile, without leakage, confirm enough blood supply, confirm successful flow of bile, and improve treatment effect.

The invention relates to a novel medical trachea cannula. The novel medical trachea cannula aims at overcoming the defects that according to existing percutaneous tracheotomy, positioning is difficult, the operating difficulty is large, repeated puncture damage is large, consumed time is long, the operation risk is high, and a postoperative trachea is prone to collapse or stenosis. In order to solve the technical problems, the novel medical trachea cannula comprises a trachea cannula, an opening in the upper portion of the trachea cannula, positioning lamps and an air bag. The novel medical trachea cannula is characterized in that through the improved trachea cannula and the improved air bag, effective ventilation of a patient can be guaranteed, trachea collapse, airway stenosis and other complications caused by extrusion during puncture can be avoided through supporting of the trachea cannula, the puncture direction can be guided through the round opening in the upper portion of the front end of the cannula and the four positioning patch lamps around the round opening, puncture accuracy is improved, and damage and complications caused by repeated puncture are reduced.

The present invention provides an inhibitor of the invasion of bone-marrow-derived vascular stem cells or inflammatory cells into blood vessel walls, a blood vessel restenosis inhibitor, and a preventive or therapeutic drug for angiitis or myocardiitis, each containing a phthalein dye compound as an active ingredient; and an instrument for treating blood vessels which is coated with a resin containing a phthalein dye compound or made of such a resin. Use of the drug of the present invention enables effective prevention of restenosis of a blood vessel after, for example, angioplasy. Moreover, it is possible to prevent the progress and disruption of a lesion of angiitis, myocarditis, or arterioscrelosis, for which no efficacious preventive or therapeutic method has been established so far, as well as microvascular ischemic diseases. By performing a medical treatment such as angioplasy using the instrument of the present invention for treating blood vessels, events of vascular restenosis can be effectively prevented.

The invention relates to an esophagus supporting device which comprises a supporting bag and an air injecting tube. The supporting bag is hollow, and a channel penetrating through the head end and the tail end of the supporting bag is formed. The front end of the air injecting tube is communicated with the supporting bag. The supporting bag is integrally in a cylindrical shape, and a plurality of pits are formed in the surface of the supporting bag. The pits in the surface of the supporting bag can protrude after being inflated, negative pressure is formed between the pits and the esophagus wall, the pits are attached to the esophagus wall as suckers, attaching is firmer, the deviation of the supporting bag in the treating process is avoided, the treating effect is enhanced, and stricture of the esophagus of a patient can be effectively prevented; furthermore, a supporting bar used in cooperation with the supporting bag can be drawn away from the esophagus after the supporting bag is delivered to the right position, the foreign body sensation of the esophagus of the patient is reduced, the comfort level of the patient is increased, and operation is convenient.

The invention discloses a 3D (three-dimensional) printing degradable trachea outer stent for treating tracheostenosis and a manufacturing method thereof. The 3D printing degradable trachea outer stent comprises an outer stent main body and a bellmouth formed in the end part of the outer stent main body, wherein the inside of the outer stent main body is a passage used for bronchus narrow position passing; a notch for connecting a passage is formed in the side wall of the outer stent main body in the axial direction; a plurality of annular bulges are formed in the outer stent main body in the peripheral direction; a suture needle hole penetrating through the passage is formed between the adjacent annular bulges; the trachea outer stent is prepared from degradable materials through 3D printing. The trachea outer stent can be used for expanding the narrow trachea; the re-compression of the peripheral tissues can be prevented; in addition, the stent naturally degrades along with the time; the injury of secondary operation is avoided; the novel thought and the effective treatment measure can be provided for tracheobronchial stenosis caused by various reasons.

The invention discloses a head-end double-lumen balloon catheter, including a catheter and a balloon arranged on the catheter and communicated with the catheter. A side lumen is disposed between the front port of the catheter and the balloon; two ends of the side lumen are respectively provided with a guide wire exit and a guide wire entrance; and the side lumen is arranged parallel to the catheter. The invention has the following beneficial effects: through the role of the balloon, when the main branch blood vessel is placed into a stent, the branch vessels can be effectively protected and severe stenosis or occlusion of the branch vessels can be avoided; through the role of the side lumen, smooth reentry of the guide wire into the branch vessels through the mesh of the main branch stentcan be ensured, and occlusion of the branch vessels also can be avoided; in addition, the balloon also takes into account the characteristics of ordinary semi-compliant balloons, pre-expands the lesion, reduces interventional supplies and medical costs, and facilitates smooth withdrawal of the guide wire.

The invention relates to a blood vessel anastomat made of nickel-titanium memory alloy, comprising a nickel-titanium memory alloy wire with a spiral memory shape at the temperature of 27-33 DEG C, two semicircle sewing needles arranged at the two ends of the nickel-titanium memory alloy wire, and two seams connecting the nickel-titanium memory alloy wire and the two seams of the two semicircle sewing needles. According to the blood vessel anastomat made of the nickel-titanium memory alloy, the technical problems of the conventional blood vessel seaming method that the seaming speed is low, the blood vessel convolution is bad, the blood flow is poor, and hemadostenosis is caused by hyperblastosis of anastomotic are solved. The blood vessel anastomat made of the nickel-titanium memory alloy has the advantages of convenience for operation, short time for seaming, and substantial improvement on the blood vessel seaming speed.