An ubiquitin ligase and the application thereof

A technology of ubiquitin ligase and protein, applied in the field of ubiquitin ligase and its application, can solve the problems that have not been verified or confirmed.
CN102168076AInactive Publication Date: 2011-08-31SINOGENOMAX
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SINOGENOMAX
Publication Date
2011-08-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides an ubiquitin ligase and the application thereof, the ubiquitin ligase is protein described as follows: protein composed of amino acid sequence shown as the SEQ ID NO:2; Or protein composed of amino acid sequence shown as the SEQ ID NO:2 with replacement, deletion and / or adding one or more amino acids and has a same ubiquitin ligase activity with the amino acid sequence shown as the SEQ ID NO:2. The invention also provides a method for preparing the ubiquitin ligase, And also provides polynucleotides of amino acid sequence for coding the ubiquitin ligase protein, gene engineering carrier comprising the polynucleotides, host cells, Also provides antibody specially combined with the ubiquitin ligase, And applications of the ubiquitin ligase, the polynucleotides, the carrier and the antibody are also provided.
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Description

technical field

[0001] The present invention relates to a new ubiquitin ligase and its application. The present invention also relates to a preparation method of the ubiquitin ligase, a gene encoding the ubiquitin ligase, a vector containing the gene, and a host cell. Antibodies to ubiquitin ligases, and uses thereof. Background technique

[0002] Endoplasmic reticulum-associated degradation (ER-associated degradation, ERAD) is an important quality control process in cells, which is very important for maintaining the homeostasis of cells. During this process, some molecular chaperones in the endoplasmic reticulum first recognize misfolded proteins or other proteins that need to be degraded, and then complete the degradation of such proteins with the participation of ubiquitin-proteasome.

[0003] Ubiquitin-proteasome is the major pathway for the targeted degradation of normal, misfolded cytoplasmic or membrane proteins in eukaryotic cells. The ubiquitin-proteasome system i...

Claims

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